Structure and dynamics of differential ligand binding in the human ρ-type GABA

Humans Receptors, GABA-A / metabolism Picrotoxin / pharmacology Ligands gamma-Aminobutyric Acid / metabolism Bicuculline / pharmacology Binding Sites
Cys-loop receptor GABA(A) receptors GABA(C) receptors cryo-EM ligand-gated ion channel ρ1 GABA(A) receptor

Journal

Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320

Informations de publication

Date de publication:
01 11 2023
Historique:
received: 19 06 2023
revised: 01 08 2023
accepted: 07 08 2023
medline: 6 11 2023
pubmed: 3 9 2023
entrez: 2 9 2023
Statut: ppublish

Résumé

The neurotransmitter γ-aminobutyric acid (GABA) drives critical inhibitory processes in and beyond the nervous system, partly via ionotropic type-A receptors (GABA

Identifiants

DOI: 10.1016/j.neuron.2023.08.006 PMID: 37659407
pubmed: 37659407
pii: S0896-6273(23)00587-1
doi: 10.1016/j.neuron.2023.08.006
pii:
doi:

Substances chimiques

Receptors, GABA-A 0
Picrotoxin ZLT174DL7U
Ligands 0
gamma-Aminobutyric Acid 56-12-2
Bicuculline Y37615DVKC

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3450-3464.e5

Informations de copyright

Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

John Cowgill (J)

Department of Biochemistry and Biophysics, SciLifeLab, Stockholm University, 17121 Solna, Sweden.

Chen Fan (C)

Department of Biochemistry and Biophysics, SciLifeLab, Stockholm University, 17121 Solna, Sweden.

Nandan Haloi (N)

Department of Applied Physics, SciLifeLab, KTH Royal Institute of Technology, 17121 Solna, Sweden.

Victor Tobiasson (V)

Department of Biochemistry and Biophysics, SciLifeLab, Stockholm University, 17121 Solna, Sweden.

Yuxuan Zhuang (Y)

Department of Biochemistry and Biophysics, SciLifeLab, Stockholm University, 17121 Solna, Sweden.

Rebecca J Howard (RJ)

Department of Biochemistry and Biophysics, SciLifeLab, Stockholm University, 17121 Solna, Sweden. Electronic address: rebecca.howard@scilifelab.se.

Erik Lindahl (E)

Department of Biochemistry and Biophysics, SciLifeLab, Stockholm University, 17121 Solna, Sweden; Department of Applied Physics, SciLifeLab, KTH Royal Institute of Technology, 17121 Solna, Sweden. Electronic address: erik.lindahl@scilifelab.se.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Structure and dynamics of differential ligand...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs GABA › Récepteurs GABA-A › Structure and dynamics of differential ligand...
questionsmedicales.fr › Préparations pharmaceutiques › Extraits de plantes › Picrotoxine › Structure and dynamics of differential ligand...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Structure and dynamics of differential ligand...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Amino-butyrates › Acide gamma-amino-butyrique › Structure and dynamics of differential ligand...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Isoquinoléines › Benzylisoquinoléines › Bicuculline › Structure and dynamics of differential ligand...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Structure and dynamics of differential ligand...