A perspective on psychedelic teratogenicity: the utility of zebrafish models.
drug safety
maternal exposure
psychedelics
teratogenicity
zebrafish
Journal
Trends in pharmacological sciences
ISSN: 1873-3735
Titre abrégé: Trends Pharmacol Sci
Pays: England
ID NLM: 7906158
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
received:
26
06
2023
revised:
03
08
2023
accepted:
07
08
2023
medline:
18
9
2023
pubmed:
3
9
2023
entrez:
2
9
2023
Statut:
ppublish
Résumé
Psychedelic drugs have experienced an unprecedented surge in recreational use within the past few years. Among recreational users, the risks of psychedelic use by pregnant and breastfeeding women are severely understudied and there is little information on the potential teratogenic effects of these drugs. We provide an overview of the previous data on psychedelic teratogenicity from rodent studies and human surveys, discuss their limitations, and propose the utility of the zebrafish as a potential effective model for investigating psychedelic teratogenicity. Recent years have validated the use of zebrafish in the study of fetal exposure and developmental biology; we highlight these properties of the zebrafish for its suitability in psychedelic toxicity research.
Identifiants
pubmed: 37659901
pii: S0165-6147(23)00171-2
doi: 10.1016/j.tips.2023.08.001
pii:
doi:
Substances chimiques
Hallucinogens
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
664-673Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.