Evaluation of pediatric epigenetic clocks across multiple tissues.
DNA methylation
Early childhood chronological age
Epigenetic clock
Gestational age
Journal
Clinical epigenetics
ISSN: 1868-7083
Titre abrégé: Clin Epigenetics
Pays: Germany
ID NLM: 101516977
Informations de publication
Date de publication:
02 09 2023
02 09 2023
Historique:
received:
08
06
2023
accepted:
12
08
2023
medline:
5
9
2023
pubmed:
3
9
2023
entrez:
2
9
2023
Statut:
epublish
Résumé
Epigenetic clocks are promising tools for assessing biological age. We assessed the accuracy of pediatric epigenetic clocks in gestational and chronological age determination. Our study used data from seven tissue types on three DNA methylation profiling microarrays and found that the Knight and Bohlin clocks performed similarly for blood cells, while the Lee clock was superior for placental samples. The pediatric-buccal-epigenetic clock performed the best for pediatric buccal samples, while the Horvath clock is recommended for children's blood cell samples. The NeoAge clock stands out for its unique ability to predict post-menstrual age with high correlation with the observed age in infant buccal cell samples. Our findings provide valuable guidance for future research and development of epigenetic clocks in pediatric samples, enabling more accurate assessments of biological age.
Sections du résumé
BACKGROUND
Epigenetic clocks are promising tools for assessing biological age. We assessed the accuracy of pediatric epigenetic clocks in gestational and chronological age determination.
RESULTS
Our study used data from seven tissue types on three DNA methylation profiling microarrays and found that the Knight and Bohlin clocks performed similarly for blood cells, while the Lee clock was superior for placental samples. The pediatric-buccal-epigenetic clock performed the best for pediatric buccal samples, while the Horvath clock is recommended for children's blood cell samples. The NeoAge clock stands out for its unique ability to predict post-menstrual age with high correlation with the observed age in infant buccal cell samples.
CONCLUSIONS
Our findings provide valuable guidance for future research and development of epigenetic clocks in pediatric samples, enabling more accurate assessments of biological age.
Identifiants
pubmed: 37660147
doi: 10.1186/s13148-023-01552-3
pii: 10.1186/s13148-023-01552-3
pmc: PMC10475199
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
142Subventions
Organisme : NIH HHS
ID : UH3 OD023248
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023288
Pays : United States
Organisme : NIH HHS
ID : U24 OD023382
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023275
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023286
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI114271
Pays : United States
Organisme : NIMHD NIH HHS
ID : R01 MD009064
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023287
Pays : United States
Organisme : NIH HHS
ID : UG3 OD023285
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023271
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI160040
Pays : United States
Organisme : NIH HHS
ID : U24 OD023319
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD072267
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023253
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023285
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD034568
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023305
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD084515
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR002534
Pays : United States
Organisme : NIH HHS
ID : UG3 OD023347
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023290
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023342
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023318
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023347
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023348
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES017885
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023282
Pays : United States
Organisme : NIH HHS
ID : UG3 OD023282
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK076648
Pays : United States
Organisme : NIH HHS
ID : U2C OD023375
Pays : United States
Investigateurs
P B Smith
(PB)
L K Newby
(LK)
L P Jacobson
(LP)
D J Catellier
(DJ)
R Gershon
(R)
D Cella
(D)
F R Laham
(FR)
J M Mansbach
(JM)
S Wu
(S)
J M Spergel
(JM)
J C Celedón
(JC)
H T Puls
(HT)
S J Teach
(SJ)
S C Porter
(SC)
I Y Waynik
(IY)
S S Iyer
(SS)
M E Samuels-Kalow
(ME)
A D Thompson
(A)
M D Stevenson
(MD)
C S Bauer
(CS)
N R Inhofe
(NR)
M Boos
(M)
C G Macias
(CG)
J Gern
(J)
D Jackson
(D)
L Bacharier
(L)
M Kattan
(M)
R Wood
(R)
K Rivera-Spoljaric
(K)
L Bacharier
(L)
T Bastain
(T)
S Farzan
(S)
R Habre
(R)
C Karr
(C)
F Tylavsky
(F)
A Mason
(A)
Q Zhao
(Q)
S Sathyanarayana
(S)
N Bush
(N)
K Z LeWinn
(KZ)
B Lester
(B)
B Carter
(B)
S Pastyrnak
(S)
C Neal
(C)
L Smith
(L)
J Helderman
(J)
C McEvoy
(C)
R Tepper
(R)
K Lyall
(K)
H Volk
(H)
R Schmidt
(R)
L Croen
(L)
M O'Shea
(M)
R Vaidya
(R)
R Obeid
(R)
C Rollins
(C)
K Bear
(K)
S Pastyrnak
(S)
M Lenski
(M)
R Singh
(R)
M Msall
(M)
J Frazier
(J)
S Gogcu
(S)
A Montgomery
(A)
K Kuban
(K)
L Douglass
(L)
H Jara
(H)
R Joseph
(R)
J M Kerver
(JM)
F Perera
(F)
Informations de copyright
© 2023. BioMed Central Ltd., part of Springer Nature.
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