The role of anti-thymocyte globulin in allogeneic stem cell transplantation (HSCT) from HLA-matched unrelated donors (MUD) for secondary AML in remission: a study from the ALWP /EBMT.
Humans
Middle Aged
Antilymphocyte Serum
/ therapeutic use
Unrelated Donors
Hematopoietic Stem Cell Transplantation
/ adverse effects
Leukemia, Myeloid, Acute
/ drug therapy
Graft vs Host Disease
/ etiology
Recurrence
Chronic Disease
Retrospective Studies
Transplantation Conditioning
/ adverse effects
Journal
Bone marrow transplantation
ISSN: 1476-5365
Titre abrégé: Bone Marrow Transplant
Pays: England
ID NLM: 8702459
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
19
06
2023
accepted:
18
08
2023
revised:
09
08
2023
medline:
4
12
2023
pubmed:
3
9
2023
entrez:
2
9
2023
Statut:
ppublish
Résumé
We compared outcomes, of 1609 patients with secondary acute myeloid leukemia (sAML) undergoing allogeneic transplantation (HSCT) in first complete remission (CR1) from matched unrelated donors (MUD) from 2010 to 2021, receiving or not receiving anti-thymocyte globulin (ATG) (ATG-1308, no ATG-301). Median age was 60.9 (range, 18.5-77.8) and 61.1 (range, 21.8-75.7) years, (p = 0.3). Graft versus host disease (GVHD) prophylaxis was cyclosporin-A with methotrexate (41%) or mycophenolate mofetil (38.2%), without significant differences between groups. Day 28, engraftment (ANC > 0.5 × 10
Identifiants
pubmed: 37660157
doi: 10.1038/s41409-023-02095-0
pii: 10.1038/s41409-023-02095-0
doi:
Substances chimiques
Antilymphocyte Serum
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1339-1347Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature Limited.
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