The prevalence and topographic distribution of penile calcification in a large cohort: a retrospective cross-sectional study.


Journal

International journal of impotence research
ISSN: 1476-5489
Titre abrégé: Int J Impot Res
Pays: England
ID NLM: 9007383

Informations de publication

Date de publication:
02 Sep 2023
Historique:
received: 04 03 2023
accepted: 18 08 2023
medline: 3 9 2023
pubmed: 3 9 2023
entrez: 2 9 2023
Statut: aheadofprint

Résumé

The prevalence of penile calcification in the population remains uncertain. This retrospective multicenter study aimed to determine the prevalence and characteristics of penile calcification in a large cohort of male patients undergoing non-contrast pelvic tomography. A total of 14 545 scans obtained from 19 participating centers between 2016 and 2022 were retrospectively analyzed within a 3-months period. Eligible scans (n = 12 709) were included in the analysis. Patient age, penile imaging status, presence of calcified plaque, and plaque measurements were recorded. Statistical analysis was performed to assess the relationships between calcified plaque, patient age, plaque characteristics, and plaque location. Among the analyzed scans, 767 (6.04%) patients were found to have at least one calcified plaque. Patients with calcified plaque had a significantly higher median age (64 years (IQR 56-72)) compared to those with normal penile evaluation (49 years (IQR 36-60) (p < 0.001). Of the patients with calcified plaque, 46.4% had only one plaque, while 53.6% had multiple plaques. There was a positive correlation between age and the number of plaques (r = 0.31, p < 0.001). The average dimensions of the calcified plaques were as follows: width: 3.9 ± 5 mm, length: 5.3 ± 5.2 mm, height: 3.5 ± 3.2 mm, with an average plaque area of 29 ± 165 mm² and mean plaque volume of 269 ± 3187 mm³. Plaques were predominantly located in the proximal and mid-penile regions (44.1% and 40.5%, respectively), with 77.7% located on the dorsal side of the penis. The hardness level of plaques, assessed by Hounsfield units, median of 362 (IQR 250-487) (range: 100-1400). Patients with multiple plaques had significantly higher Hounsfield unit values compared to those with a single plaque (p = 0.003). Our study revealed that patients with calcified plaques are older and have multiple plaques predominantly located on the dorsal and proximal side of the penis.

Identifiants

pubmed: 37660216
doi: 10.1038/s41443-023-00758-6
pii: 10.1038/s41443-023-00758-6
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2023. The Author(s), under exclusive licence to Springer Nature Limited.

Références

Devine CJ, Somers KD, Jordan SG, Schlossberg SM. Proposal: trauma as the cause of the Peyronie’s lesion. J Urol. 1997;157:285–90.
doi: 10.1016/S0022-5347(01)65361-8 pubmed: 8976281
Chung E, Ralph D, Kadioglu A, Garaffa G, Shamsodini A, Bivalacqua T, et al. Evidence-based management guidelines on Peyronie’s disease. J Sex Med. 2016;13:905–23.
doi: 10.1016/j.jsxm.2016.04.062 pubmed: 27215686
Di Maida F, Cito G, Lambertini L, Valastro F, Morelli G, Mari A, et al. The natural history of Peyronie’s disease. World J Mens Health. 2021;39:399–405.
doi: 10.5534/wjmh.200065 pubmed: 32648381
Garaffa G, Trost LW, Serefoglu EC, Ralph D, Hellstrom WJG. Understanding the course of Peyronie’s disease. Int J Clin Pract. 2013;67:781–8.
doi: 10.1111/ijcp.12129 pubmed: 23869679
Sommer F, Schwarzer U, Wassmer G, Bloch W, Braun M, Klotz T, et al. Epidemiology of Peyronie’s disease. Int J Impot Res. 2002;14:379–83.
doi: 10.1038/sj.ijir.3900863 pubmed: 12454689
Schwarzer U, Sommer F, Klotz T, Braun M, Reifenrath B, Engelmann U. The prevalence of Peyronie’s disease: results of a large survey. BJU Int. 2001;88:727–30.
doi: 10.1046/j.1464-4096.2001.02436.x pubmed: 11890244
Arafa M, Eid H, El-Badry A, Ezz-Eldine K, Shamloul R. The prevalence of Peyronie’s disease in diabetic patients with erectile dysfunction. Int J Impot Res. 2007;19:213–7.
doi: 10.1038/sj.ijir.3901518 pubmed: 16915304
Kadioglu A, Dincer M, Salabas E, Culha MG, Akdere H, Cilesiz NC. A population-based study of Peyronie’s disease in Turkey: prevalence and related comorbidities. Sex Med. 2020;8:679–85.
doi: 10.1016/j.esxm.2020.09.002 pubmed: 33243422 pmcid: 7691981
Goldstein I, McLane MP, Xiang Q, Wolfe HR, Hu Y, Gelbard MK. Long-term curvature deformity characterization in men previously treated with Collagenase Clostridium Histolyticum for Peyronie’s disease, subgrouped by penile plaque calcification. Urology. 2020;146:145–51.
doi: 10.1016/j.urology.2020.08.045 pubmed: 32896582
Levine L, Rybak J, Corder C, Farrel MR. Peyronie’s disease plaque calcification–prevalence, time to identification, and development of a new grading classification. J Sex Med. 2013;10:3121–8.
doi: 10.1111/jsm.12334 pubmed: 24119147
Wymer K, Ziegelmann M, Savage J, Kohler T, Trost L. Plaque calcification: an important predictor of collagenase clostridium histolyticum treatment outcomes for men with Peyronie’s disease. Urology 2018;119:109–14.
doi: 10.1016/j.urology.2018.06.003 pubmed: 29908867
Patel DP, Christensen MB, Hotaling JM, Pastuszak AW. A review of inflammation and fibrosis: implications for the pathogenesis of Peyronie’s disease. World J Urol. 2020;38:253–61.
doi: 10.1007/s00345-019-02815-6 pubmed: 31190155
Vernet D, Nolazco G, Cantini L, Magee TR, Qian A, Rajfer J, et al. Evidence that osteogenic progenitor cells in the human tunica albuginea may originate from stem cells: implications for peyronie disease. Biol Reprod. 2005;73:1199–210.
doi: 10.1095/biolreprod.105.041038 pubmed: 16093362
Gonzalez-Cadavid NF, Magee TR, Ferrini M, Qian A, Vernet D, Rajfer J. Gene expression in Peyronie’s disease. Int J Impot Res. 2002;14:361–74.
doi: 10.1038/sj.ijir.3900873 pubmed: 12454687
Rainer QC, Rodriguez AA, Bajic P, Galor A, Ramasamy R, Masterson TA. Implications of calcification in Peyronie’s disease, a review of the literature. Urology. 2021;152:52–9.
doi: 10.1016/j.urology.2021.01.007 pubmed: 33476600
Vande Berg JS, Devine CJ, Horton CE, Somers KD, Wright GL, Leffell MS, et al. Mechanisms of calcification in Peyronie’s disease. J Urol 1982;127:52–4.
doi: 10.1016/S0022-5347(17)53599-5 pubmed: 7057504
Bekos A, Arvaniti M, Hatzimouratidis K, Moysidis K, Tzortzis V, Hatzichristou D. The natural history of Peyronie’s disease: an ultrasonography-based study. Eur Urol. 2008;53:644–50.
doi: 10.1016/j.eururo.2007.07.013 pubmed: 17673362
Parmar M, Masterson JM, Masterson TA. The role of imaging in the diagnosis and management of Peyronie’s disease. Curr Opin Urol. 2020;30:283–9.
doi: 10.1097/MOU.0000000000000754 pubmed: 32205808
Gündoğdu E, Emekli E. Calcified Peyronie’s disease frequency on computed tomography. Turk J Urol. 2022;48:196–200.
doi: 10.5152/tud.2022.21346 pubmed: 35634937 pmcid: 9730267
Pawłowska E, Bianek-Bodzak A. Imaging modalities and clinical assesment in men affected with Peyronie’s disease. Pol J Radiol. 2011;76:33–7.
pubmed: 22802839 pmcid: 3389927
Andresen R, Wegner HE, Miller K, Banzer D. Imaging modalities in Peyronie’s disease. An intrapersonal comparison of ultrasound sonography, X-ray in mammography technique, computerized tomography, and nuclear magnetic resonance in 20 patients. Eur Urol 1998;34:128–34.
doi: 10.1159/000019698 pubmed: 9693248
Hounsfield GN. Computed medical imaging. Nobel lecture, Decemberr 8, 1979. J Comput Assist Tomogr. 1980;4:665–74.
doi: 10.1097/00004728-198010000-00017 pubmed: 6997341
Glide-Hurst C, Chen D, Zhong H, Chetty IJ. Changes realized from extended bit-depth and metal artifact reduction in CT. Med Phys. 2013;40:061711.
doi: 10.1118/1.4805102 pubmed: 23718590
Ouzaid I, Al-qahtani S, Dominique S, Hupertan V, Fernandez P, Hermieu JF, et al. A 970 Hounsfield units (HU) threshold of kidney stone density on non-contrast computed tomography (NCCT) improves patients’ selection for extracorporeal shockwave lithotripsy (ESWL): evidence from a prospective study. BJU Int. 2012;110:E438–442.
doi: 10.1111/j.1464-410X.2012.10964.x pubmed: 22372937
Nakasato T, Morita J, Ogawa Y. Evaluation of hounsfield units as a predictive factor for the outcome of extracorporeal shock wave lithotripsy and stone composition. Urolithiasis. 2015;43:69–75.
doi: 10.1007/s00240-014-0712-x pubmed: 25139151
Breyer BN, Shindel AW, Huang YC, Eisenberg ML, Weiss DA, Lue TF, et al. Are sonographic characteristics associated with progression to surgery in men with Peyronie’s disease? J Urol. 2010;183:1484–8.
doi: 10.1016/j.juro.2009.12.026 pubmed: 20171694 pmcid: 3565595
Trama F, Illiano E, Iacono F, Ruffo A, di Lauro G, Aveta A, et al. Use of penile shear wave elastosonography for the diagnosis of Peyronie’s Disease: a prospective case-control study. Basic Clin Androl. 2022;15:32.
Yuruk E, Serefoglu EC. Re: Peyronie’s disease plaque calcification–prevalence, time to identification, and development of a new grading classification. J Sex Med. 2014;11:1351.
doi: 10.1111/jsm.12479 pubmed: 24877175
McCullough A, Trussler J, Alnammi M, Schober J, Flacke S. The use of penile computed tomography cavernosogram in the evaluation of Peyronie’s disease: a pilot study. J Sex Med. 2020;17:1041–3.
doi: 10.1016/j.jsxm.2020.01.023 pubmed: 32146129

Auteurs

Caner Baran (C)

Department of Urology, University of Health Science, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey. drcanerbaran@hotmail.com.

Mehmet Gokhan Culha (MG)

Department of Urology, University of Health Science, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey.

Recep Yilmaz Bayraktarli (RY)

Department of Radiology, University of Health Science, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey.

Berat Cem Ozgur (BC)

Department of Urology, University of Health Science, Ankara Education and Research Hospital, Ankara, Turkey.

Arif Bedirhan Bayraktar (AB)

Department of Urology, University of Health Science, Ankara Education and Research Hospital, Ankara, Turkey.

Cagri Oktem (C)

Department of Urology, University of Health Science, Ankara Education and Research Hospital, Ankara, Turkey.

Hakki Mete Cek (HM)

Department of Urology, Trakya University Faculty of Medicine, Edirne, Turkey.

Burak Akgul (B)

Department of Urology, Trakya University Faculty of Medicine, Edirne, Turkey.

Aykut Alkan (A)

Department of Radiology, Trakya University Faculty of Medicine, Edirne, Turkey.

Erdogan Aglamis (E)

Department of Urology, University of Health Science, Elazig Fethi Sekin City Hospital, Elazig, Turkey.

Mehmet Sezai Ogras (MS)

Department of Urology, University of Health Science, Elazig Fethi Sekin City Hospital, Elazig, Turkey.

Turgay Kacan (T)

Department of Urology, Ankara City Hospital, Ankara, Turkey.

Coskun Kaya (C)

Department of Urology, Eskisehir City Hospital, Ankara, Turkey.

Mehmet Erhan Aydin (ME)

Department of Urology, Eskisehir City Hospital, Ankara, Turkey.

Kasim Emre Ergun (KE)

Department of Urology, Ege University Faculty of Medicine, İzmir, Turkey.

Mehmet Yoldas (M)

Department of Urology, Tepecik Education and Research Hospital, İzmir, Turkey.

Murat Cakan (M)

Department of Urology, University of Health Science, Diskapi Education and Research Hospital, Ankara, Turkey.

Huseyin Mert Durak (HM)

Department of Urology, University of Health Science, Diskapi Education and Research Hospital, Ankara, Turkey.

Serkan Gonultas (S)

Department of Urology, Gaziosmanpasa Education and Research Hospital, İstanbul, Turkey.

Berk Bulut (B)

Department of Urology, Gaziosmanpasa Education and Research Hospital, İstanbul, Turkey.

Kazim Dogan (K)

Department of Urology, Gaziantep Private Liv Hospital, Gaziantep, Turkey.

Ozgur Efiloglu (O)

Department of Urology, Istanbul Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, Turkey.

Mustafa Kaan Akalin (MK)

Department of Urology, Istanbul Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, Turkey.

Asif Yildirim (A)

Department of Urology, Istanbul Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, Turkey.

Yavuz Onur Danacioglu (YO)

Department of Urology, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey.

Erhan Demirelli (E)

Department of Urology, Giresun University Faculty of Medicine, Giresun, Turkey.

Mustafa Bahadir Can Balci (MBC)

Department of Urology, University of Health Science, Istanbul Taksim Health Application and Research Center, Istanbul, Turkey.

Cem Tugrul Gezmis (CT)

Department of Urology, University of Health Science, Istanbul Taksim Health Application and Research Center, Istanbul, Turkey.

Murat Tuncer (M)

Department of Urology, University of Health Science, Kartal Dr. Lutfi Kirdar City Hospital, Istanbul, Turkey.

Murat Can (M)

Department of Urology, University of Health Science, Kartal Dr. Lutfi Kirdar City Hospital, Istanbul, Turkey.

Mustafa Koray Kirdag (MK)

Department of Urology, Samsun Education and Research Hospital, Samsun, Turkey.

Mustafa Aydin (M)

Department of Urology, Samsun Education and Research Hospital, Samsun, Turkey.

Selim Yazar (S)

Department of Urology, Recep Tayyip Erdogan University Education and Research Hospital, Rize, Turkey.

Gokhan Calik (G)

Istanbul Medipol University, Faculty of Medicine, Istanbul, Turkey.

Vahit Guzelburc (V)

Istanbul Medipol University, Faculty of Medicine, Istanbul, Turkey.

Ahmet Guzel (A)

Department of Urology, Aydin State Hospital, Aydin, Turkey.

Alper Otunctemur (A)

Department of Urology, University of Health Science, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey.

Ates Kadioglu (A)

Department of Urology, Section of Andrology, Istanbul Faculty of Medicine, Istanbul, Turkey.

Classifications MeSH