The prevalence and topographic distribution of penile calcification in a large cohort: a retrospective cross-sectional study.
Journal
International journal of impotence research
ISSN: 1476-5489
Titre abrégé: Int J Impot Res
Pays: England
ID NLM: 9007383
Informations de publication
Date de publication:
02 Sep 2023
02 Sep 2023
Historique:
received:
04
03
2023
accepted:
18
08
2023
medline:
3
9
2023
pubmed:
3
9
2023
entrez:
2
9
2023
Statut:
aheadofprint
Résumé
The prevalence of penile calcification in the population remains uncertain. This retrospective multicenter study aimed to determine the prevalence and characteristics of penile calcification in a large cohort of male patients undergoing non-contrast pelvic tomography. A total of 14 545 scans obtained from 19 participating centers between 2016 and 2022 were retrospectively analyzed within a 3-months period. Eligible scans (n = 12 709) were included in the analysis. Patient age, penile imaging status, presence of calcified plaque, and plaque measurements were recorded. Statistical analysis was performed to assess the relationships between calcified plaque, patient age, plaque characteristics, and plaque location. Among the analyzed scans, 767 (6.04%) patients were found to have at least one calcified plaque. Patients with calcified plaque had a significantly higher median age (64 years (IQR 56-72)) compared to those with normal penile evaluation (49 years (IQR 36-60) (p < 0.001). Of the patients with calcified plaque, 46.4% had only one plaque, while 53.6% had multiple plaques. There was a positive correlation between age and the number of plaques (r = 0.31, p < 0.001). The average dimensions of the calcified plaques were as follows: width: 3.9 ± 5 mm, length: 5.3 ± 5.2 mm, height: 3.5 ± 3.2 mm, with an average plaque area of 29 ± 165 mm² and mean plaque volume of 269 ± 3187 mm³. Plaques were predominantly located in the proximal and mid-penile regions (44.1% and 40.5%, respectively), with 77.7% located on the dorsal side of the penis. The hardness level of plaques, assessed by Hounsfield units, median of 362 (IQR 250-487) (range: 100-1400). Patients with multiple plaques had significantly higher Hounsfield unit values compared to those with a single plaque (p = 0.003). Our study revealed that patients with calcified plaques are older and have multiple plaques predominantly located on the dorsal and proximal side of the penis.
Identifiants
pubmed: 37660216
doi: 10.1038/s41443-023-00758-6
pii: 10.1038/s41443-023-00758-6
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature Limited.
Références
Devine CJ, Somers KD, Jordan SG, Schlossberg SM. Proposal: trauma as the cause of the Peyronie’s lesion. J Urol. 1997;157:285–90.
doi: 10.1016/S0022-5347(01)65361-8
pubmed: 8976281
Chung E, Ralph D, Kadioglu A, Garaffa G, Shamsodini A, Bivalacqua T, et al. Evidence-based management guidelines on Peyronie’s disease. J Sex Med. 2016;13:905–23.
doi: 10.1016/j.jsxm.2016.04.062
pubmed: 27215686
Di Maida F, Cito G, Lambertini L, Valastro F, Morelli G, Mari A, et al. The natural history of Peyronie’s disease. World J Mens Health. 2021;39:399–405.
doi: 10.5534/wjmh.200065
pubmed: 32648381
Garaffa G, Trost LW, Serefoglu EC, Ralph D, Hellstrom WJG. Understanding the course of Peyronie’s disease. Int J Clin Pract. 2013;67:781–8.
doi: 10.1111/ijcp.12129
pubmed: 23869679
Sommer F, Schwarzer U, Wassmer G, Bloch W, Braun M, Klotz T, et al. Epidemiology of Peyronie’s disease. Int J Impot Res. 2002;14:379–83.
doi: 10.1038/sj.ijir.3900863
pubmed: 12454689
Schwarzer U, Sommer F, Klotz T, Braun M, Reifenrath B, Engelmann U. The prevalence of Peyronie’s disease: results of a large survey. BJU Int. 2001;88:727–30.
doi: 10.1046/j.1464-4096.2001.02436.x
pubmed: 11890244
Arafa M, Eid H, El-Badry A, Ezz-Eldine K, Shamloul R. The prevalence of Peyronie’s disease in diabetic patients with erectile dysfunction. Int J Impot Res. 2007;19:213–7.
doi: 10.1038/sj.ijir.3901518
pubmed: 16915304
Kadioglu A, Dincer M, Salabas E, Culha MG, Akdere H, Cilesiz NC. A population-based study of Peyronie’s disease in Turkey: prevalence and related comorbidities. Sex Med. 2020;8:679–85.
doi: 10.1016/j.esxm.2020.09.002
pubmed: 33243422
pmcid: 7691981
Goldstein I, McLane MP, Xiang Q, Wolfe HR, Hu Y, Gelbard MK. Long-term curvature deformity characterization in men previously treated with Collagenase Clostridium Histolyticum for Peyronie’s disease, subgrouped by penile plaque calcification. Urology. 2020;146:145–51.
doi: 10.1016/j.urology.2020.08.045
pubmed: 32896582
Levine L, Rybak J, Corder C, Farrel MR. Peyronie’s disease plaque calcification–prevalence, time to identification, and development of a new grading classification. J Sex Med. 2013;10:3121–8.
doi: 10.1111/jsm.12334
pubmed: 24119147
Wymer K, Ziegelmann M, Savage J, Kohler T, Trost L. Plaque calcification: an important predictor of collagenase clostridium histolyticum treatment outcomes for men with Peyronie’s disease. Urology 2018;119:109–14.
doi: 10.1016/j.urology.2018.06.003
pubmed: 29908867
Patel DP, Christensen MB, Hotaling JM, Pastuszak AW. A review of inflammation and fibrosis: implications for the pathogenesis of Peyronie’s disease. World J Urol. 2020;38:253–61.
doi: 10.1007/s00345-019-02815-6
pubmed: 31190155
Vernet D, Nolazco G, Cantini L, Magee TR, Qian A, Rajfer J, et al. Evidence that osteogenic progenitor cells in the human tunica albuginea may originate from stem cells: implications for peyronie disease. Biol Reprod. 2005;73:1199–210.
doi: 10.1095/biolreprod.105.041038
pubmed: 16093362
Gonzalez-Cadavid NF, Magee TR, Ferrini M, Qian A, Vernet D, Rajfer J. Gene expression in Peyronie’s disease. Int J Impot Res. 2002;14:361–74.
doi: 10.1038/sj.ijir.3900873
pubmed: 12454687
Rainer QC, Rodriguez AA, Bajic P, Galor A, Ramasamy R, Masterson TA. Implications of calcification in Peyronie’s disease, a review of the literature. Urology. 2021;152:52–9.
doi: 10.1016/j.urology.2021.01.007
pubmed: 33476600
Vande Berg JS, Devine CJ, Horton CE, Somers KD, Wright GL, Leffell MS, et al. Mechanisms of calcification in Peyronie’s disease. J Urol 1982;127:52–4.
doi: 10.1016/S0022-5347(17)53599-5
pubmed: 7057504
Bekos A, Arvaniti M, Hatzimouratidis K, Moysidis K, Tzortzis V, Hatzichristou D. The natural history of Peyronie’s disease: an ultrasonography-based study. Eur Urol. 2008;53:644–50.
doi: 10.1016/j.eururo.2007.07.013
pubmed: 17673362
Parmar M, Masterson JM, Masterson TA. The role of imaging in the diagnosis and management of Peyronie’s disease. Curr Opin Urol. 2020;30:283–9.
doi: 10.1097/MOU.0000000000000754
pubmed: 32205808
Gündoğdu E, Emekli E. Calcified Peyronie’s disease frequency on computed tomography. Turk J Urol. 2022;48:196–200.
doi: 10.5152/tud.2022.21346
pubmed: 35634937
pmcid: 9730267
Pawłowska E, Bianek-Bodzak A. Imaging modalities and clinical assesment in men affected with Peyronie’s disease. Pol J Radiol. 2011;76:33–7.
pubmed: 22802839
pmcid: 3389927
Andresen R, Wegner HE, Miller K, Banzer D. Imaging modalities in Peyronie’s disease. An intrapersonal comparison of ultrasound sonography, X-ray in mammography technique, computerized tomography, and nuclear magnetic resonance in 20 patients. Eur Urol 1998;34:128–34.
doi: 10.1159/000019698
pubmed: 9693248
Hounsfield GN. Computed medical imaging. Nobel lecture, Decemberr 8, 1979. J Comput Assist Tomogr. 1980;4:665–74.
doi: 10.1097/00004728-198010000-00017
pubmed: 6997341
Glide-Hurst C, Chen D, Zhong H, Chetty IJ. Changes realized from extended bit-depth and metal artifact reduction in CT. Med Phys. 2013;40:061711.
doi: 10.1118/1.4805102
pubmed: 23718590
Ouzaid I, Al-qahtani S, Dominique S, Hupertan V, Fernandez P, Hermieu JF, et al. A 970 Hounsfield units (HU) threshold of kidney stone density on non-contrast computed tomography (NCCT) improves patients’ selection for extracorporeal shockwave lithotripsy (ESWL): evidence from a prospective study. BJU Int. 2012;110:E438–442.
doi: 10.1111/j.1464-410X.2012.10964.x
pubmed: 22372937
Nakasato T, Morita J, Ogawa Y. Evaluation of hounsfield units as a predictive factor for the outcome of extracorporeal shock wave lithotripsy and stone composition. Urolithiasis. 2015;43:69–75.
doi: 10.1007/s00240-014-0712-x
pubmed: 25139151
Breyer BN, Shindel AW, Huang YC, Eisenberg ML, Weiss DA, Lue TF, et al. Are sonographic characteristics associated with progression to surgery in men with Peyronie’s disease? J Urol. 2010;183:1484–8.
doi: 10.1016/j.juro.2009.12.026
pubmed: 20171694
pmcid: 3565595
Trama F, Illiano E, Iacono F, Ruffo A, di Lauro G, Aveta A, et al. Use of penile shear wave elastosonography for the diagnosis of Peyronie’s Disease: a prospective case-control study. Basic Clin Androl. 2022;15:32.
Yuruk E, Serefoglu EC. Re: Peyronie’s disease plaque calcification–prevalence, time to identification, and development of a new grading classification. J Sex Med. 2014;11:1351.
doi: 10.1111/jsm.12479
pubmed: 24877175
McCullough A, Trussler J, Alnammi M, Schober J, Flacke S. The use of penile computed tomography cavernosogram in the evaluation of Peyronie’s disease: a pilot study. J Sex Med. 2020;17:1041–3.
doi: 10.1016/j.jsxm.2020.01.023
pubmed: 32146129