Biomimetic Connection of Transcutaneous Implants with Skin.
electrospinning
highly porous fleece
organic-inorganic adhesives
percutaneous implants
transcutaneous implants
Journal
Advanced healthcare materials
ISSN: 2192-2659
Titre abrégé: Adv Healthc Mater
Pays: Germany
ID NLM: 101581613
Informations de publication
Date de publication:
12 2023
12 2023
Historique:
revised:
23
08
2023
received:
11
04
2023
medline:
5
12
2023
pubmed:
3
9
2023
entrez:
3
9
2023
Statut:
ppublish
Résumé
Bacterial infection is a crucial complication in implant restoration, in particular in permanent skin-penetrating implants. Therein, the resulting gap between transcutaneous implant and skin represents a permanent infection risk, limiting the field of application and the duration of application. To overcome this limitation, a tight physiological connection is required to achieve a biological and mechanical welding for a long-term stable closure including self-healing probabilities. This study describes a new approach, wherein the implant is connected covalently to a highly porous electrospun fleece featuring physiological dermal integration potential. The integrative potential of the scaffold is shown in vitro and confirmed in vivo, further demonstrating tissue integration by neovascularization, extracellular matrix formation, and prevention of encapsulation. To achieve a covalent connection between fleece and implant surface, self-initiated photografting and photopolymerization of hydroxyethylmethacrylate is combined with a new crosslinker (methacrylic acid coordinated titanium-oxo clusters) on proton-abstractable implant surfaces. For implant modification, the attached fleece is directed perpendicular from the implant surface into the surrounding dermal tissue. First in vitro skin implantations demonstrate the implants' dermal integration capability as well as wound closure potential on top of the fleece by epithelialization, establishing a bacteria-proof and self-healing connection of skin and transcutaneous implant.
Identifiants
pubmed: 37660290
doi: 10.1002/adhm.202301131
doi:
Substances chimiques
Titanium
D1JT611TNE
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2301131Subventions
Organisme : Bundesamt für Ausrüstung, Informationstechnik und Nutzung der Bundeswehr
Informations de copyright
© 2023 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH.
Références
C. Willy, C. Krettek, Unfallchirurg. 2017, 120, 395.
M. Örgel, A. Ranker, A. Harb, C. Krettek, H.-H. Aschoff, Orthopade. 2021, 50, 4.
federal health reporting - Gesundheitsberichterstattung des Bundes. Operationen und Prozeduren der vollstationären Patientinnen und Patienten in Krankenhäusern: 5-864 Amputation und Exartikulation untere Extremität / 5-865 Amputation und Exartikulation Fuß. 2017/2016/2019. Available online: https://www.gbe-bund.de (accessed: February 2023).
C. J. Pendegrass, B. Tucker, S. Patel, R. Dowling, G. W. Blunn, J. Biomed. Mater. Res., Part A. 2012, 100, 3463.
D. Isackson, L. D. McGill, K. N. Bachus, Med. Eng. Phys. 2011, 33, 418.
M. Pitkin, C. Cassidy, M. A. Shevtsov, J. R. Jarrell, H. Park, B. J. Farrell, J. F. Dalton, W. L. Childers, R. S. Kistenberg, K. Oh, A. N. Klishko, B. I. Prilutsky, Mil Med. 2021, 186, 688.
E. C. L. Bolle, N. Bartnikowski, P. Haridas, T. J. Parker, J. F. Fraser, S. D. Gregory, T. R. Dargaville, J. Biomed. Mater. Res. B Appl. Biomater. 2020, 108, 738.
T. Weigel, C. Malkmus, V. Weigel, M. Wußmann, C. Berger, J. Brennecke, F. Groeber-Becker, J. Hansmann, Adv. Mater. 2022, 34, 2106780.
T. Weigel, T. Schmitz, T. Pfister, S. Gaetzner, M. Jannasch, R. Al-Hijailan, S. Schürlein, S. Suliman, K. Mustafa, J. Hansmann, Sci. Rep. 2018, 8, 14545.
J. D. Bryers, C. M. Giachelli, B. D. Ratner, Biotechnol. Bioeng. 2012, 109, 1898.
O. WICHTERLE, D. LÍM, Nature 1960, 185, 117.
M. Steenackers, A. Küller, S. Stoycheva, M. Grunze, R. Jordan, Langmuir. 2009, 25, 2225.
V. Štengl, V. Houšková, S. Bakardjieva, N. Murafa, V. Havlín, J. Phys. Chem. C 2008, 112, 19979.
P. Gorbovyi, A. P. Diaz-Gomez, M. Traore, L. Museur, L. Rozes, F. Ribot, C. Sanchez, A. I. Kuznetsov, B. N. Chichkov, A. Kanaev, Mater. Res. Bull. 2019, 114, 130.
P. Gorbovyi, A. Uklein, M. Traore, L. Museur, A. Kanaev, Mater. Res. Express. 2014, 1, 045039.
S. Bocchini, G. Fornasieri, L. Rozes, S. Trabelsi, J. Galy, N. E. Zafeiropoulos, M. Stamm, J.-F. Gérard, C. Sanchez, Chem. Commun. 2005, 2600.
J.-M. Yeh, C.-J. Weng, K.-Y. Huang, H.-Y. Huang, Y.-H. Yu, C.-H. Yin, J. Appl. Polym. Sci. 2004, 94, 400.
R. L. Holmes, J. A. Campbell, R. Linser, J. M. Hook, R. P. Burford, Polymer. 2011, 52, 4471.
K. B. Keys, F. M. Andreopoulos, N. A. Peppas, Macromolecules 1998, 31, 8149.
M. Camail, M. Humbert, A. Margaillan, A. Riondel, J. L. Vernet, Polymer 1998, 39, 6525.
B. Christ, W. Glaubitt, K. Berberich, T. Weigel, J. Probst, G. Sextl, S. Dembski, Materials 2022, 15, 2752.
L. Rozes, C. Sanchez, Chem. Soc. Rev. 2011, 40, 1006.
M. Czakler, C. Artner, U. Schubert, Monatsh. Chem. 2015, 146, 1249.
L. Wu, J. Liu, M. Vockenhuber, Y. Ekinci, S. Castellanos, Eur. J. Inorg. Chem. 2019, 2019, 4136.
O. Kameneva, A. I. Kuznestov, L. A. Smirnova, L. Rozes, C. Sanchez, A. Alexandrov, N. Bityurin, K. Chhor, A. Kanaev, J. Mater. Chem. 2005, 15, 3380.
H. Wang, H. R. Brown, Macromol. Rapid Commun. 2004, 25, 1095.
J. Löblein, T. Lorson, M. Komma, T. Kielholz, M. Windbergs, P. D. Dalton, R. Luxenhofer, Beilstein J. Org. Chem. 2021, 17, 2095.
M. Steenackers, A. M. Gigler, N. Zhang, F. Deubel, M. Seifert, L. H. Hess, C. H. Y. X. Lim, K. P. Loh, J. A. Garrido, R. Jordan, M. Stutzmann, I. D. Sharp, J. Am. Chem. Soc. 2011, 133, 10490.
M. Steenackers, S. Q. Lud, M. Niedermeier, P. Bruno, D. M. Gruen, P. Feulner, M. Stutzmann, J. A. Garrido, R. Jordan, J. Am. Chem. Soc. 2007, 129, 15655.
M. Steenackers, I. D. Sharp, K. Larsson, N. A. Hutter, M. Stutzmann, R. Jordan, Chem. Mater. 2010, 22, 272.
J. Yang, L. Hou, B. Xu, N. Zhang, Y. Liang, W. Tian, D. Dong, Macromol. Rapid Commun. 2014, 35, 1224.
C. Chu, L. Liu, S. Rung, Y. Wang, Y. Ma, C. Hu, X. Zhao, Y. Man, Y. Qu, J. Biomed. Mater. Res., Part A. 2020, 108, 127.
L. Davenport Huyer, S. Pascual-Gil, Y. Wang, S. Mandla, B. Yee, M. Radisic, Adv. Funct. Mater. 2020, 30, 1909331.
M. Jannasch, S. Gaetzner, T. Weigel, H. Walles, T. Schmitz, J. Hansmann, Sci. Rep. 2017, 7, 1689.
Y. Chen, Z. Jia, M. Shafiq, X. Xie, X. Xiao, R. Castro, J. Rodrigues, J. Wu, G. Zhou, X. Mo, Colloids Surf B Biointerfaces. 2021, 201, 111637.
H. Cao, K. McHugh, S. Y. Chew, J. M. Anderson, J. Biomed. Mater. Res., Part A. 2010, 93, 1151.
K. Wang, W.-D. Hou, X. Wang, C. Han, I. Vuletic, N. Su, W.-X. Zhang, Q.-S. Ren, L. Chen, Y. Luo, Biomaterials. 2016, 102, 249.
M. MacEwan, L. Jeng, T. Kovács, E. Sallade, Bioengineering 2022, 10, 9.
J. Jiang, Z. Li, H. Wang, Y. Wang, M. A. Carlson, M. J. Teusink, M. R. MacEwan, L. Gu, J. Xie, Adv. Healthcare Mater. 2016, 5, 2993.
I. Ludolph, J. S. Gruener, A. Kengelbach-Weigand, C. Fiessler, R. E. Horch, M. Schmitz, J. Plast Reconstr. Aesthet Surg. 2019, 72, 1555.
S. F. Badylak, J. E. Valentin, A. K. Ravindra, G. P. McCabe, A. M. Stewart-Akers, Tissue Eng., Part A. 2008, 14, 1835.
N. Efron, in Comprehensive biomaterials II, (Ed., P. Ducheyne), Elsevier, Amsterdam, Netherlands, 2017, pp 686-714.
B. Holt, A. Tripathi, J. R. Morgan, J. Biomech. 2011, 44, 1491.
G. Dearnaley, J. H. Arps, Surf. Coat. Technol. 2005, 200, 2518.
Y. Qi, E. Konca, A. T. Alpas, Surf. Sci. 2006, 600, 2955.
A. Rossi, A. Appelt-Menzel, S. Kurdyn, H. Walles, F. Groeber, J. Vis. Exp. 2015, 96, 52576.
M. Jannasch, F. Groeber, N. W. Brattig, C. Unger, H. Walles, J. Hansmann, Exp Parasitol. 2015, 150, 22.
M. Jannasch, T. Weigel, L. Engelhardt, J. Wiezoreck, S. Gaetzner, H. Walles, T. Schmitz, J. Hansmann, ALTEX. 2017, 34, 253.
C. Reuter, F. Imdahl, L. Hauf, E. Vafadarnejad, P. Fey, T. Finger, H. Walles, A.-E. Saliba, F. Groeber-Becker, M. Engstler, Vector-borne Trypanosoma brucei parasites develop in artificial human skin and persist as skin tissue forms. 2021. https://doi.org/10.1101/2021.05.13.443986