Systems analysis reveals differential expression of endocervical genes in African women randomized to DMPA-IM, LNG implant or cu-IUD.
Contraception
Female genital tract
Mucosa
Randomized clinical trial
Reproductive health
Transcriptome
Journal
Clinical immunology (Orlando, Fla.)
ISSN: 1521-7035
Titre abrégé: Clin Immunol
Pays: United States
ID NLM: 100883537
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
18
07
2023
accepted:
22
08
2023
medline:
16
11
2023
pubmed:
4
9
2023
entrez:
3
9
2023
Statut:
ppublish
Résumé
Although effective contraceptives are crucial for preventing unintended pregnancies, evidence suggests that their use may perturb the female genital tract (FGT). A comparative analysis of the effects of the most common contraceptives on the FGT have not been evaluated in a randomized clinical trial setting. Here, we evaluated the effect of three long-acting contraceptive methods: depot medroxyprogesterone acetate(DMPA-IM), levonorgestrel(LNG) implant, and a copper intrauterine device (Cu-IUD), on the endocervical host transcriptome in 188 women from the Evidence for Contraceptive Options and HIV Outcomes Trial (ECHO) trial. Cu-IUD usage showed the most extensive transcriptomic changes, and was associated with inflammatory and anti-viral host responses. DMPA-IM usage was enriched for pathways associated with T cell responses. LNG implant had the mildest effect on endocervical gene expression, and was associated with growth factor signaling. These data provide a mechanistic basis for the diverse influence that varying contraceptives have on the FGT.
Identifiants
pubmed: 37660744
pii: S1521-6616(23)00513-2
doi: 10.1016/j.clim.2023.109750
pmc: PMC10570927
pii:
doi:
Substances chimiques
Copper
789U1901C5
Levonorgestrel
5W7SIA7YZW
Contraceptive Agents
0
Types de publication
Randomized Controlled Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
109750Subventions
Organisme : NIGMS NIH HHS
ID : T32 GM142617
Pays : United States
Informations de copyright
Copyright © 2023. Published by Elsevier Inc.
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