Molecular epidemiology and clinical characteristics of enteroviruses associated HFMD in Chengdu, China, 2013-2022.
Change
Clinical characteristics
Enterovirus
Epidemiology
HFMD
Journal
Virology journal
ISSN: 1743-422X
Titre abrégé: Virol J
Pays: England
ID NLM: 101231645
Informations de publication
Date de publication:
03 09 2023
03 09 2023
Historique:
received:
21
07
2023
accepted:
26
08
2023
medline:
5
9
2023
pubmed:
4
9
2023
entrez:
3
9
2023
Statut:
epublish
Résumé
This study aims to investigate molecular epidemiology and clinical characteristics of enterovirus associated hand-foot-mouth disease (HFMD) in Chengdu, China, 2013-2022. Monitoring the molecular epidemiology and clinical features of HFMD for up to 10 years may provide some ideas for future protection and control measures. We conducted a retrospective analysis of the medical records of all patients with laboratory-confirmed HFMD-related enterovirus infection at the West China Second University Hospital from January 2013 to December 2022. We described the characteristics in serotype, age, sex distribution and hospitalization of enterovirus infection cases using data analysis and graphic description. A total of 29,861 laboratory-confirmed cases of HFMD-related enterovirus infection were reported from 2013 to 2022. There was a significant reduction in the number and proportion of EV-A71 cases after 2016, from 1713 cases (13.60%) in 2013-2015 to 150 cases (1.83%) in 2017-2019. During the COVID-19 pandemic, EV-A71 cases even disappeared. The proportion of CV-A16 cases decreased from 13.96% in 2013-2015 to 10.84% in 2017-2019 and then to 4.54% in 2020-2022. Other (non-EV-A71 and non-CV-A16) serotypes accounted for 95.45% during 2020-2022, with CV-A6 accounting for 50.39% and CV-A10 accounting for 10.81%. Thus, CV-A6 and CV-A10 became the main prevalent serotypes. Furthermore, There was no significant difference in the enterovirus prevalence rate between males and females. The hospitalization rate of EV-A71 patients was higher that of other serotypes. In general, the proportion of HFMD hospitalizations caused by other pathogens except for EV-A71, CV-A16, CV-A10 and CV-A16 was second only to that caused by EV-A71. The proportion of children over 4 years old infected with enterovirus increased. The incidence of HFMD associated with enterovirus infection has decreased significantly and CV-A6 has been the main pathogen of HFMD in Chengdu area in recent years. The potential for additional hospitalizations for other untested enterovirus serotypes suggested that attention should also be paid to the harms of infections with unknown enterovirus serotypes. Children with HFMD were older. The development of new diagnostic reagents and vaccines may play an important role in the prevention and control of enterovirus infection.
Identifiants
pubmed: 37661256
doi: 10.1186/s12985-023-02169-x
pii: 10.1186/s12985-023-02169-x
pmc: PMC10476316
doi:
Substances chimiques
antineoplaston A10
16VY3TM7ZO
Antigens, Viral
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
202Informations de copyright
© 2023. BioMed Central Ltd., part of Springer Nature.
Références
Cox B, Levent F. Hand, foot, and mouth disease. JAMA. 2018;320:2492.
doi: 10.1001/jama.2018.17288
pubmed: 30561482
Li XW, Ni X, Qian SY, Wang Q, Jiang RM, Xu WB, Zhang YC, Yu GJ, Chen Q, Shang YX, Zhao CS, Yu H, Zhang T, Liu G, Deng HL, Gao J, Ran XG, Yang QZ, Xu BL, Huang XY, Wu XD, Bao YX, Chen YP, Chen ZH, Liu QQ, Lu GP, Liu CF, Wang RB, Zhang GL, Gu F, Xu HM, Li Y, Yang T. Chinese guidelines for the diagnosis and treatment of hand, foot and mouth disease (2018 edition). World J Pediatr. 2018;14:437–47.
doi: 10.1007/s12519-018-0189-8
pubmed: 30280313
Puenpa J, Wanlapakorn N, Vongpunsawad S, Poovorawan Y. The history of enterovirus A71 outbreaks and molecular epidemiology in the Asia-Pacific region. J Biomed Sci. 2019;26:75.
doi: 10.1186/s12929-019-0573-2
pubmed: 31627753
pmcid: 6798416
Yi Z, Pei S, Suo W, Wang X, Huang Z, Yi A, Wang B, He Z, Wang R, Li Y, Fan W, Huang X. Epidemiological characteristics, routine laboratory diagnosis, clinical signs and risk factors for hand, -foot -and -mouth disease: a systematic review and meta-analysis. PLoS ONE. 2022;17: e0267716.
doi: 10.1371/journal.pone.0267716
pubmed: 35482791
pmcid: 9049560
Nassef C, Ziemer C, Morrell DS. Hand-foot-and-mouth disease: a new look at a classic viral rash. Curr Opin Pediatr. 2015;27:486–91.
doi: 10.1097/MOP.0000000000000246
pubmed: 26087425
Mao QY, Wang Y, Bian L, Xu M, Liang Z. EV71 vaccine, a new tool to control outbreaks of hand, foot and mouth disease (HFMD). Expert Rev Vaccines. 2016;15:599–606.
doi: 10.1586/14760584.2016.1138862
pubmed: 26732723
Swain SK, Gadnayak A, Mohanty JN, Sarangi R, Das J. Does enterovirus 71 urge for effective vaccine control strategies? Challenges and current opinion. Rev Med Virol. 2022;32: e2322.
doi: 10.1002/rmv.2322
pubmed: 34997684
Zhang X, Zhang Y, Li H, Liu L. Hand-foot-and-mouth disease-associated enterovirus and the development of multivalent HFMD vaccines. Int J Mol Sci. 2022. https://doi.org/10.3390/ijms24010169 .
doi: 10.3390/ijms24010169
pubmed: 36614339
pmcid: 9821249
Esposito S, Principi N. Hand, foot and mouth disease: current knowledge on clinical manifestations, epidemiology, aetiology and prevention. Eur J Clin Microbiol Infect Dis. 2018;37:391–8.
doi: 10.1007/s10096-018-3206-x
pubmed: 29411190
Swain SK, Panda S, Sahu BP, Sarangi R. Activation of host cellular signaling and mechanism of enterovirus 71 viral proteins associated with hand Foot and Mouth Disease. Viruses. 2022;14(10):2190.
doi: 10.3390/v14102190
pubmed: 36298746
pmcid: 9609926
Sun Q, Li J, Wang R, Sun T, Zong Y, Wang C, Liu Y, Li X, Song Y, Zhang Y. Coxsackievirus A6 infection causes neurogenic pathogenesis in a neonatal murine model. Viruses. 2023. https://doi.org/10.3390/v15020511 .
doi: 10.3390/v15020511
pubmed: 37896902
pmcid: 10612101
Song Y, Zhang Y, Han Z, Xu W, Xiao J, Wang X, Wang J, Yang J, Yu Q, Yu D, Chen J, Huang W, Li J, Xie T, Lu H, Ji T, Yang Q, Yan D, Zhu S, Xu W. Genetic recombination in fast-spreading coxsackievirus A6 variants: a potential role in evolution and pathogenicity. Virus Evol. 2020;6:veaa048.
doi: 10.1093/ve/veaa048
pubmed: 34804589
pmcid: 8597624
Duan X, Zhang C, Wang X, Ren X, Peng H, Tang X, Zhang L, Chen Z, Ye Y, Zheng M, Zhong W, Chen X, Zeng Y, Yuan P, Long L. Molecular epidemiology and clinical features of hand, foot and mouth disease requiring hospitalization after the use of enterovirus A71 inactivated vaccine in chengdu, China, 2017–2022: a descriptive study, Emerg. Microbes Infect. 2022;11:2510–9.
doi: 10.1080/22221751.2022.2125346
Tang XQ, Zhang LZ, Meng JT, Chen H, Cheng Y, Yuan P, Long L. Epidemiological characteristics of hand, foot, and mouth disease and the effect of EV71 vaccination in Chengdu from 2012 to 2020. Sichuan Da Xue Xue Bao Yi Xue Ban. 2022;53:1074–80.
pubmed: 36443055
Tong WB, Wu XQ, He M, Yang FJ, Jiang Y, Zhang G, Zeng PB. Epidemiological and etiological characteristics of hand, foot, and mouth disease before and after introducing enterovirus 71 vaccines in Sichuan, China: a 6-year retrospective study. Chin Med J. 2021;134:3017–9.
doi: 10.1097/CM9.0000000000001632
pubmed: 34730898
pmcid: 8710323
Han Y, Chen Z, Zheng K, Li X, Kong J, Duan X, Xiao X, Guo B, Luan R, Long L. Epidemiology of hand, foot, and mouth disease before and after the introduction of enterovirus 71 vaccines in Chengdu, China, 2009–2018. Pediatr Infect Dis J. 2020;39:969–78.
doi: 10.1097/INF.0000000000002745
pubmed: 32433221
Song S, Wang P, Li J, Nie X, Liu L, Liu S, Yin X, Lin A. The indirect impact of control measures in COVID-19 pandemic on the incidence of other infectious diseases in China. Public Health Pract. 2022;4: 100278.
doi: 10.1016/j.puhip.2022.100278
Muselli M, Cofini V, Mammarella L, Carmignani C, Fabiani L, Desideri G, Necozione S. The impact of COVID-19 pandemic on emergency services. Ann Ig. 2022;34:248–58.
pubmed: 34652412
Paiva R, Martins C, Rodrigues F, Domingues M. Impact of COVID-19 on a paediatric emergency service. Eur J Pediatr. 2021;180:2571–9.
doi: 10.1007/s00431-021-04095-y
pubmed: 34003356
pmcid: 8129601
Xiao J, Zhu Q, Yang F, Zeng S, Zhu Z, Gong D, Li Y, Zhang L, Li B, Zeng W, Li X, Rong Z, Hu J, He G, Sun J, Lu J, Liu T, Ma W, Sun L. The impact of enterovirus A71 vaccination program on hand, foot, and mouth disease in Guangdong, China: a longitudinal surveillance study. J Infect. 2022;85:428–35.
doi: 10.1016/j.jinf.2022.06.020
pubmed: 35768049
Li Y, Zhou Y, Cheng Y, Wu P, Zhou C, Cui P, Song C, Liang L, Wang F, Qiu Q, Guo C, Zeng M, Long L, Cowling BJ, Yu H. Effectiveness of EV-A71 vaccination in prevention of paediatric hand, foot, and mouth disease associated with EV-A71 virus infection requiring hospitalisation in Henan, China, 2017–18: a test-negative case-control study, Lancet Child Adolesc. Health. 2019;3:697–704.
Wu H, Xue M, Wu C, Lu Q, Ding Z, Wang X, Fu T, Yang K, Lin J. Trend of hand, foot, and mouth disease from 2010 to 2021 and estimation of the reduction in enterovirus 71 infection after vaccine use in Zhejiang Province, China. PLoS One. 2022;17: e0274421.
doi: 10.1371/journal.pone.0274421
pubmed: 36126038
pmcid: 9488823
Zhu P, Ji W, Li D, Li Z, Chen Y, Dai B, Han S, Chen S, Jin Y, Duan G. Current status of hand-foot-and-mouth disease. J Biomed Sci. 2023;30:15.
doi: 10.1186/s12929-023-00908-4
pubmed: 36829162
pmcid: 9951172
Liyuan SU, Liangzhi Z, Yong YUE, Min HU, Zhimiao YU, Lin MA. Analysis of Prevention and Control Effect of EV71 Vaccine Against HFMD in Chengdu City. J Prevent Med Inf. 2020;36:531–8.
Wang J, Jiang L, Zhang C, He W, Tan Y, Ning C. The changes in the epidemiology of hand, foot, and mouth disease after the introduction of the EV-A71 vaccine. Vaccine. 2021;39:3319–23.
doi: 10.1016/j.vaccine.2021.05.009
pubmed: 33994239
Hu L, Maimaiti H, Zhou L, Gao J, Lu Y. Changing serotypes of hand, foot and mouth disease in Shanghai, 2017–2019. Gut Pathog. 2022;14:12.
doi: 10.1186/s13099-022-00485-1
pubmed: 35313977
pmcid: 8935267
Hong J, Liu F, Qi H, Tu W, Ward MP, Ren M, Zhao Z, Su Q, Huang J, Chen X, Le J, Ren X, Hu Y, Cowling B, Li Z, Chang Z, Zhang Z. Changing epidemiology of hand, foot, and mouth disease in China, 2013–2019: a population-based study. Lancet Reg Health West Pac. 2022;20: 100370.
doi: 10.1016/j.lanwpc.2021.100370
pubmed: 35036978
pmcid: 8743221