Relationship between arterial stiffness, left ventricular diastolic function, and renal function in chronic kidney disease.
Arterial stiffness
Chronic kidney disease
Echocardiography, Doppler
IgA nephropathy
Left ventricular diastolic dysfunction
Journal
BMC nephrology
ISSN: 1471-2369
Titre abrégé: BMC Nephrol
Pays: England
ID NLM: 100967793
Informations de publication
Date de publication:
03 09 2023
03 09 2023
Historique:
received:
12
06
2023
accepted:
24
08
2023
medline:
5
9
2023
pubmed:
4
9
2023
entrez:
3
9
2023
Statut:
epublish
Résumé
In chronic kidney disease, IgA nephropathy, and left ventricular diastolic dysfunction have prognostic significance as well. However, the relationship between diastolic dysfunction, arterial stiffness, and renal function has not been fully elucidated. 79 IgA nephropathy patients (aged 46 ± 11 years) and 50 controls were investigated. Tissue Doppler imaging was used to measure early (Ea) and late (Aa) diastolic velocities. Arterial stiffness was measured by a photoplethysmographic (stiffness index (SI)) and an oscillometric method (aortic pulse wave velocity (PWVao)). We compared the IgAN patients to a similar cardiovascular risk group with a preserved eGFR. A strong correlation was found between Ea/Aa and SI (p < 0.001), also with PWVao (p < 0.001), just in IgAN, and with eGFR (p < 0.001) in both groups. IgAN patients were divided into groups CKD1-2 vs. CKD3-5. In the CKD 3-5 group, the incidence of diastolic dysfunction increased significantly: 39% vs. 72% (p = 0.003). Left ventricle rigidity (LVR) was calculated, which showed a close correlation with SI (p = 0.009) and eGFR (p = 0.038). By linear regression analysis, the independent predictors of SI were age, E/A, and E/Ea; SI was the predictor of LVR; and E/A and hypertension were the predictors of eGFR. In chronic kidney disease, increased cardiac rigidity and vascular stiffness coexist with decreased renal function, which is directly connected to diastolic dysfunction and vascular stiffness. On the basis of comparing the CKD group to the control group, vascular alterations in very early CKD can be identified.
Identifiants
pubmed: 37661275
doi: 10.1186/s12882-023-03308-w
pii: 10.1186/s12882-023-03308-w
pmc: PMC10476356
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
261Informations de copyright
© 2023. BioMed Central Ltd., part of Springer Nature.
Références
J Hypertens. 2020 Apr;38(4):588-598
pubmed: 31809464
J Am Soc Echocardiogr. 2004 Mar;17(3):290-7
pubmed: 14981433
J Am Soc Nephrol. 2019 Jun;30(6):918-928
pubmed: 31040188
Heart Fail Rev. 2015 May;20(3):291-303
pubmed: 25716909
J Am Soc Echocardiogr. 2022 Apr;35(4):395-407
pubmed: 34915133
J Hypertens. 2023 Feb 1;41(2):295-302
pubmed: 36583355
Am J Nephrol. 1999;19(5):546-51
pubmed: 10575181
Kidney Blood Press Res. 2018;43(4):1388-1407
pubmed: 30153666
Hypertension. 2008 Jul;52(1):107-14
pubmed: 18474835
J Am Soc Nephrol. 2000 Dec;11(12):2395-2403
pubmed: 11095664
J Am Soc Nephrol. 2009 Dec;20(12):2651-60
pubmed: 19850955
J Hypertens. 2019 Jun;37(6):1176-1182
pubmed: 30624367
N Engl J Med. 2004 Sep 23;351(13):1296-305
pubmed: 15385656
Kidney Int Suppl. 2008 Dec;(111):S19-23
pubmed: 19034320
J Hypertens. 2016 Apr;34(4):762-71
pubmed: 26828786
Nephrol Dial Transplant. 2002;17 Suppl 1:29-36
pubmed: 11812909
Perit Dial Int. 2000 Jul-Aug;20(4):461-6
pubmed: 11007379
Kidney Int Suppl. 2003 May;(84):S80-3
pubmed: 12694316
Nephrol Dial Transplant. 2012 Mar;27(3):1064-70
pubmed: 21813825
J Am Coll Cardiol. 2007 Oct 16;50(16):1570-7
pubmed: 17936156
J Mol Cell Cardiol. 2018 Aug;121:124-133
pubmed: 29981797
Heart. 2005 Dec;91(12):1551-6
pubmed: 16287739
Kidney Blood Press Res. 2009;32(3):223-9
pubmed: 19622897
Kidney Blood Press Res. 2011;34(3):158-66
pubmed: 21474963
Semin Dial. 2016 Nov;29(6):435-441
pubmed: 27556272
Nephrol Dial Transplant. 2005 Aug;20(8):1533-9
pubmed: 15956069
Am J Hypertens. 2005 Apr;18(4 Pt 1):477-85
pubmed: 15831356
Blood Press. 2018 Feb;27(1):32-40
pubmed: 28922954
Semin Dial. 2012 Jan-Feb;25(1):35-41
pubmed: 22273530
Kidney Int. 2005 Jan;67(1):217-26
pubmed: 15610245
Nephrol Dial Transplant. 2011 Nov;26(11):3732-9
pubmed: 21430181
Blood Press. 2005;14(4):233-7
pubmed: 16126557
Hypertension. 2002 Jan;39(1):10-5
pubmed: 11799071
Nephrol Dial Transplant. 2023 Feb 13;38(2):372-383
pubmed: 35451488
Circulation. 2010 Jun 15;121(23):2592-600
pubmed: 20547939
J Am Heart Assoc. 2016 Mar 25;5(3):e002693
pubmed: 27016574
J Hypertens. 2006 Aug;24(8):1449-56
pubmed: 16877944
N Engl J Med. 2020 Dec 03;383(23):2219-2229
pubmed: 33264825
Ren Fail. 2021 Dec;43(1):1454-1462
pubmed: 34704891
J Am Coll Cardiol. 2015 Nov 10;66(19):2116-2125
pubmed: 26541923
Front Cardiovasc Med. 2022 Mar 25;9:844312
pubmed: 35402554
J Am Coll Cardiol. 2011 Apr 5;57(14):1511-22
pubmed: 21453829
High Blood Press Cardiovasc Prev. 2018 Mar;25(1):97-104
pubmed: 29330703
Nefrologia. 2008;28(2):135-42
pubmed: 18454701
Ther Apher Dial. 2019 Apr;23(2):108-117
pubmed: 30255628
J Renin Angiotensin Aldosterone Syst. 2004 Sep;5(3):102-8
pubmed: 15526244
N Engl J Med. 2016 Nov 10;375(19):1868-1877
pubmed: 27959663
IEEE Trans Biomed Eng. 2007 Dec;54(12):2268-75
pubmed: 18075043
Am J Hypertens. 2008 Aug;21(8):866-72
pubmed: 18551104
Am J Hypertens. 2015 Mar;28(3):393-400
pubmed: 25125636
Eur Heart J Cardiovasc Pharmacother. 2023 Feb 2;9(2):183-191
pubmed: 36639130
Am J Kidney Dis. 2002 Feb;39(2 Suppl 1):S1-266
pubmed: 11904577
J Am Coll Cardiol. 2014 Dec 23;64(24):2619-2629
pubmed: 25524341
Am J Kidney Dis. 1996 Mar;27(3):347-54
pubmed: 8604703
Clin Sci (Lond). 2002 Oct;103(4):371-7
pubmed: 12241535
J Am Soc Echocardiogr. 2006 Mar;19(3):266-73
pubmed: 16500488
Zhonghua Yu Fang Yi Xue Za Zhi. 2006 Mar;40(2):113-5
pubmed: 16640913
J Am Coll Cardiol. 2004 Feb 4;43(3):360-7
pubmed: 15013115
Circulation. 2010 Feb 2;121(4):505-11
pubmed: 20083680
J Am Coll Cardiol. 2005 Jan 18;45(2):272-7
pubmed: 15653027