A case of cutaneous malignant glomus tumor.
glomus tumor
skin neoplasms
soft tissue neoplasms
Journal
Journal of cutaneous pathology
ISSN: 1600-0560
Titre abrégé: J Cutan Pathol
Pays: United States
ID NLM: 0425124
Informations de publication
Date de publication:
Jan 2024
Jan 2024
Historique:
revised:
20
08
2023
received:
04
05
2023
accepted:
26
08
2023
pubmed:
4
9
2023
medline:
4
9
2023
entrez:
4
9
2023
Statut:
ppublish
Résumé
Glomus tumors are well-known but relatively rare vascular neoplasms, with their malignant counterparts still being rarer. There are very few reports of cutaneous malignant glomus tumors, and the current limited evidence suggests that they follow a more indolent course than deep-seated malignant glomus tumors. Herein, we are reporting a case of cutaneous malignant glomus tumor. A 94-year-old male presented with a right-sided ulcerated scalp lesion, which, on biopsy, showed a diffusely infiltrative epithelioid malignancy with considerable pleomorphism and a notable perivascular growth pattern. The tumor cells were positive for smooth muscle actin (SMA) and h-caldesmon, and negative for cytokeratin MNF116, CK5, p40, S100, SOX10, HMB45, Melan-A, ERG, CD31, CD45, CD3, CD20, ALK, desmin, CD68, CD34, and HHV8. A diagnosis of cutaneous malignant glomus tumor was made, and the patient underwent a wider excision. Cutaneous malignant glomus tumors are extremely rare and should be considered when examining unusual cutaneous mesenchymal tumors.
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
50-52Informations de copyright
© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Références
Morey VK, Garg B, Kotwal PP. Glomus tumours of the hand: review of the literature. J Clin Orthop Trauma. 2016;7(4):286-291. doi:10.1016/j.jcot.2016.04.006
Jayaraj G, Sherlin HJ, Ramani P, et al. Malignant glomus tumor of the head and neck-a review. J Oral Maxillofac Surg Med Pathol. 2019;31:228-230. doi:10.1016/j.ajoms.2018.12.009
Heys SD, Brittenden J, Atkinson P, Eremin O. Glomus tumour: an analysis of 43 patients and review of the literature. Br J Surg. 1992;79(4):345-347. doi:10.1002/bjs.1800790423
De Chiara A, Apice G, Mori S, et al. Malignant glomus tumour: a case report and review of the literature. Sarcoma. 2003;7(2):87-91. doi:10.1080/1357714031000081207
Toti L, Manzia TM, Roma S, et al. Rare malignant glomus tumour of the stomach with liver metastases. Radiol Case Rep. 2019;14(4):463-467. doi:10.1016/j.radcr.2019.01.012
Zhang Q, Wang S, Divakaran J, et al. Malignant glomus tumour of the lung. Pathology. 2010;42(6):594-596. doi:10.3109/00313025.2010.508738
Folpe AL, Fanburg-Smith JC, Miettinen M, Weiss SW. Atypical and malignant glomus tumors: analysis of 52 cases, with a proposal for the reclassification of glomus tumors. Am J Surg Pathol. 2001;25(1):1-12. doi:10.1097/00000478-200101000-00001
Aslam N, Qazi Z, Ahmad AH, Khan RU. Malignant glomus tumour of the larynx: first case report and literature review. J Laryngo Otol. 2012;126(7):743-746. doi:10.1017/S0022215112000631
Specht K, Antonescu C. Glomus tumour. In: The WHO Classification of Tumours Editorial Board, ed. Soft Tissue and Bone Tumours. 5th ed. International Agency for Research on Cancer; 2020:179-181.
Luzar B, Martin B, Fisher C, Calonje E. Cutaneous malignant glomus tumours: applicability of currently established malignancy criteria for tumours occurring in the skin. Pathology. 2018;50(7):711-717. doi:10.1016/j.pathol.2018.08.005