Clinical consequences of a polygenic predisposition to benign lower white blood cell counts: Consequences of benign WBC count genetics.
White blood cell count
azathioprine
bone marrow biopsy
pharmacogenomics
polygenic score
taxane
Journal
medRxiv : the preprint server for health sciences
Titre abrégé: medRxiv
Pays: United States
ID NLM: 101767986
Informations de publication
Date de publication:
21 Aug 2023
21 Aug 2023
Historique:
pubmed:
4
9
2023
medline:
4
9
2023
entrez:
4
9
2023
Statut:
epublish
Résumé
Polygenic variation unrelated to disease contributes to interindividual variation in baseline white blood cell (WBC) counts, but its clinical significance is undefined. We investigated the clinical consequences of a genetic predisposition toward lower WBC counts among 89,559 biobank participants from tertiary care centers using a polygenic score for WBC count (PGS
Identifiants
pubmed: 37662324
doi: 10.1101/2023.08.20.23294331
pmc: PMC10473820
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NHGRI NIH HHS
ID : U01 HG006385
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000445
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR025141
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG004424
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG006389
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG006828
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG006380
Pays : United States
Organisme : NIGMS NIH HHS
ID : RC2 GM092618
Pays : United States
Organisme : NIGMS NIH HHS
ID : P50 GM115305
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG006379
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG011181
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM131770
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM130791
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG006830
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG006375
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG004438
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG006382
Pays : United States
Organisme : NHLBI NIH HHS
ID : U19 HL065962
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM126535
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD074711
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG006388
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG006378
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR024975
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS032830
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG004798
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002243
Pays : United States
Déclaration de conflit d'intérêts
DECLARATION OF INTERESTS SCB has served on the scientific advisory board for Ipsen Pharmaceuticals and Fennec Pharmaceuticals. The remaining authors have no conflicts of interest.