The combined effect of lifestyle factors and polygenic scores on age at onset in Parkinson's disease.
Age at onset
GBA1
Lifestyle factor
Parkinson’s disease
Polygenic score
Journal
medRxiv : the preprint server for health sciences
Titre abrégé: medRxiv
Pays: United States
ID NLM: 101767986
Informations de publication
Date de publication:
25 Aug 2023
25 Aug 2023
Historique:
pubmed:
4
9
2023
medline:
4
9
2023
entrez:
4
9
2023
Statut:
epublish
Résumé
To investigate the association between a Parkinson's disease (PD)-specific polygenic score (PGS) and protective lifestyle factors on age at onset (AAO) in PD. We included data from 4375 patients with idiopathic PD, 167 patients with The PGS showed a negative association with AAO (β=-1.07, p=6×10 In our cohort, coffee, tobacco, aspirin, and PGS are independent predictors of PD AAO. Additionally, lifestyle factors seem to have a greater influence on AAO than common genetic risk variants with aspirin presenting the largest effect. External validation of our findings is needed.
Identifiants
pubmed: 37662355
doi: 10.1101/2023.08.25.23294466
pmc: PMC10473779
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : Intramural NIH HHS
ID : ZIA AG000935
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA NS003154
Pays : United States
Déclaration de conflit d'intérêts
Conflicts of Interests All authors declare no financial or non-financial competing interests.