Portal Vein Thrombosis in Patients with Liver Cirrhosis: What Went Wrong?
biomarkers
end stage liver disease
gut functional bacteria
portal vein obstruction
Journal
International journal of general medicine
ISSN: 1178-7074
Titre abrégé: Int J Gen Med
Pays: New Zealand
ID NLM: 101515487
Informations de publication
Date de publication:
2023
2023
Historique:
received:
26
04
2023
accepted:
10
08
2023
medline:
4
9
2023
pubmed:
4
9
2023
entrez:
4
9
2023
Statut:
epublish
Résumé
This study aimed to explore inflammatory biomarkers, stool's functional bacterial groups and their possible link to portal vein thrombosis (PVT) in patients with liver cirrhosis (LC). An observational study of 300 participants: 200 inhospital cirrhotic patients, who met inclusion criteria, equally assigned into two groups, based on the presence or absence of PVT and 100 healthy controls was carried out. The PVT group displayed significant differences related to older age, cigarettes smoking history, emergency admission, higher Child-Pugh score, metabolic related disorders and nonalcoholic fatty liver disease, as well as non-obstructive aspects, with chronic thrombi. The PVT group exhibited significant differences related to biomarkers such as tumor necrosis factor (TNF)-alpha, C-reactive protein (CRP), D-dimers (D-D), as well as gut overall dysbiosis (DB) and alteration of different functional bacterial groups of the gut microbiota. Strong positive correlations were observed between PVT severity, and TNF-alpha, CRP, D-D as well as lipopolysaccharide (LPS) positive bacteria. Esophageal varices, age and abdominal pain were independent predictors for PVT severity as well as CRP, TNF-alpha and D-D. Patients with LC and PVT displayed elevation of TNF-alpha, CRP, D-D alterations of the functional gut microbiota, as well as several morphological and clinical particularities. Although the LPS positive gut microbiota was linked to inflammatory biomarkers and PVT severity, it was not proven to be an independent predictor of the PVT severity like CRP, TNF-alpha and D-D.
Identifiants
pubmed: 37662503
doi: 10.2147/IJGM.S413438
pii: 413438
pmc: PMC10473422
doi:
Types de publication
Journal Article
Langues
eng
Pagination
3889-3906Informations de copyright
© 2023 Georgescu et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
Références
Cardiovasc Diagn Ther. 2017 Dec;7(Suppl 3):S207-S218
pubmed: 29399524
J Clin Gastroenterol. 2010 Jul;44(6):448-51
pubmed: 19730112
World J Gastroenterol. 2019 Sep 7;25(33):4814-4834
pubmed: 31543676
Saudi J Gastroenterol. 2015 May-Jun;21(3):165-74
pubmed: 26021776
Radiology. 2012 Oct;265(1):124-32
pubmed: 22891357
Ann Hepatol. 2015 Jan-Feb;14(1):20-7
pubmed: 25536638
J Hepatol. 2009 Oct;51(4):682-9
pubmed: 19464747
PLoS One. 2014 Nov 13;9(11):e112501
pubmed: 25393320
Gut. 2001 Nov;49(5):720-4
pubmed: 11600478
Thromb Res. 2019 Feb;174:137-140
pubmed: 30597344
Am J Epidemiol. 2022 Mar 24;191(5):856-866
pubmed: 34999759
Haematologica. 2016 Apr;101(4):e162-3
pubmed: 27033239
Exp Ther Med. 2021 Jul;22(1):759
pubmed: 34035856
Cardiovasc Ther. 2022 Jun 15;2022:4415876
pubmed: 35821704
Aliment Pharmacol Ther. 2006 Mar 15;23(6):767-75
pubmed: 16556179
Int J Surg Case Rep. 2016;28:93-96
pubmed: 27693837
Arch Intern Med. 2002 Apr 8;162(7):747-56
pubmed: 11926847
Clin Nucl Med. 2013 Feb;38(2):e60-5
pubmed: 23334142
World J Gastroenterol. 2015 Nov 7;21(41):11542-51
pubmed: 26556985
Vasc Med. 2016 Feb;21(1):61-9
pubmed: 26584887
Cell Immunol. 2018 Jun;328:86-92
pubmed: 29653689
Ann Hepatol. 2013 Nov-Dec;12(6):952-8
pubmed: 24114826
Thromb J. 2021 Jun 27;19(1):45
pubmed: 34176487
ISRN Hepatol. 2013 Jul 22;2013:541836
pubmed: 27335828
Int J Gen Med. 2022 Jun 08;15:5513-5531
pubmed: 35702368
Lancet. 1999 Apr 3;353(9159):1167-73
pubmed: 10209995
J Agric Food Chem. 2012 Jul 18;60(28):6977-83
pubmed: 22720759
Int J Crit Illn Inj Sci. 2018 Apr-Jun;8(2):73-77
pubmed: 29963409
Dermatol Surg. 2011 Aug;37(8):1089-99
pubmed: 21635628
Platelets. 2019;30(8):1047-1052
pubmed: 31076004
Int J Womens Health. 2022 Jan 26;14:41-56
pubmed: 35136356
J Viral Hepat. 2012 Feb;19(2):e212-9
pubmed: 22239521
BMJ Case Rep. 2021 Jul 9;14(7):
pubmed: 34244194
Hepatology. 2010 Jan;51(1):210-8
pubmed: 19821530
Pharmacol Res Perspect. 2020 Jun;8(3):e00601
pubmed: 32476298
Hematology Am Soc Hematol Educ Program. 2014 Dec 5;2014(1):318-20
pubmed: 25696872
J Hepatol. 2009 Nov;51(5):931-8
pubmed: 19726097
J Hepatol. 2016 Jan;64(1):179-202
pubmed: 26516032
Aliment Pharmacol Ther. 2005 Jan 1;21(1):1-9
pubmed: 15644039
World J Gastroenterol. 2006 Apr 7;12(13):2115-9
pubmed: 16610067
J Hepatol. 2009 Oct;51(4):632-4
pubmed: 19660824
Gastroenterol Rep (Oxf). 2017 May;5(2):138-147
pubmed: 28533911
Abdom Imaging. 2008 Jan-Feb;33(1):72-9
pubmed: 17694406
Ann Gastroenterol. 2018 May-Jun;31(3):315-329
pubmed: 29720857
Eur J Gastroenterol Hepatol. 2020 Mar;32(3):401-405
pubmed: 31356372
Liver Transpl. 2016 Mar;22(3):352-65
pubmed: 26684272
BMC Gastroenterol. 2007 Aug 15;7:34
pubmed: 17697371
Eur J Gastroenterol Hepatol. 2021 Dec 1;33(1S Suppl 1):e108-e113
pubmed: 33208682
J Hepatol. 2004 May;40(5):736-41
pubmed: 15094219
World J Gastroenterol. 2010 Jan 14;16(2):143-55
pubmed: 20066733
J Hepatol. 2019 Nov;71(5):1038-1050
pubmed: 31442476
Genes (Basel). 2017 Sep 30;8(10):
pubmed: 28973971
Am J Case Rep. 2015 Sep 17;16:627-30
pubmed: 26378714
Intern Emerg Med. 2022 Aug;17(5):1327-1334
pubmed: 35076898
Aliment Pharmacol Ther. 2010 Feb 1;31(3):366-74
pubmed: 19863496
Lancet. 1974 Aug 17;2(7877):394-7
pubmed: 4136718
Mass Spectrom Rev. 2013 May-Jun;32(3):188-217
pubmed: 22996584
J Clin Transl Hepatol. 2019 Jun 28;7(2):154-164
pubmed: 31293916
World J Gastroenterol. 2015 Jun 14;21(22):6769-84
pubmed: 26078553
Clin Liver Dis. 2015 Feb;19(1):199-221
pubmed: 25454305
Br J Surg. 1973 Aug;60(8):646-9
pubmed: 4541913
J Clin Exp Hepatol. 2015 Mar;5(1):22-40
pubmed: 25941431
Dig Liver Dis. 2017 Feb;49(2):113-120
pubmed: 27965037
J Hepatol. 2001 Jan;34(1):32-7
pubmed: 11211904
J Int Med Res. 2013 Jun;41(3):664-72
pubmed: 23637275
Ann Gastroenterol. 2015 Jan-Mar;28(1):31-40
pubmed: 25608575
Circulation. 2017 Apr 25;135(17):1671-1673
pubmed: 28438808
Nature. 2020 May;581(7808):310-315
pubmed: 32433607
Hepatology. 2000 Mar;31(3):587-91
pubmed: 10706547
Endoscopy. 1982 Jan;14(1):4-5
pubmed: 7035153
Anesth Analg. 2012 Feb;114(2):275-85
pubmed: 22104070
Int J Mol Sci. 2022 Sep 17;23(18):
pubmed: 36142813
Curr Opin Clin Nutr Metab Care. 2018 Jul;21(4):294-301
pubmed: 29634493
Nat Rev Gastroenterol Hepatol. 2014 Jul;11(7):435-46
pubmed: 24686266
Nat Rev Gastroenterol Hepatol. 2021 Mar;18(3):167-180
pubmed: 33257833
J Hepatol. 2015 Sep;63(3):743-52
pubmed: 26047908
Front Genet. 2015 Jun 23;6:219
pubmed: 26157455
Sci Rep. 2020 Jul 23;10(1):12296
pubmed: 32704001
Viszeralmedizin. 2014 Dec;30(6):375-80
pubmed: 26288604
Gastroenterology. 2001 Feb;120(2):490-7
pubmed: 11159889
J Hepatol. 2000 May;32(5):865-71
pubmed: 10845677
Aliment Pharmacol Ther. 2009 Nov 1;30(9):881-94
pubmed: 19678814