Biosynthesis of Lacto-N-biose I from starch and N-acetylglucosamine via an in vitro synthetic enzymatic biosystem.
Human milk oligosaccharide
In vitro synthetic enzymatic biosystem
Lacto-N-biose I
Thermostable enzyme
Journal
Synthetic and systems biotechnology
ISSN: 2405-805X
Titre abrégé: Synth Syst Biotechnol
Pays: China
ID NLM: 101694371
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
14
04
2023
revised:
07
08
2023
accepted:
16
08
2023
medline:
4
9
2023
pubmed:
4
9
2023
entrez:
4
9
2023
Statut:
epublish
Résumé
Human milk oligosaccharides (HMOs) are very distinctive components in human milk and are beneficial for infant health. Lacto-N-biose I (LNB) is the core structural unit of HMOs, which could be used for the synthesis of other HMOs. In this study, an ATP-free in vitro synthetic enzymatic biosystem contained four thermostable enzymes (alpha-glucan phosphorylase from
Identifiants
pubmed: 37663063
doi: 10.1016/j.synbio.2023.08.004
pii: S2405-805X(23)00061-3
pmc: PMC10468323
doi:
Types de publication
Journal Article
Langues
eng
Pagination
555-562Informations de copyright
© 2023 The Authors.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest in this study.
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