Stem Cell Scaffolds for the Treatment of Spinal Cord Injury-A Review.
axonal regrowth
composite scaffolds
natural polymer scaffolds
neural stem cells
neuroregeneration
scaffolding
spinal cord injury
stem cell therapy
tissue engineering
Journal
Biomechanics (Basel, Switzerland)
ISSN: 2673-7078
Titre abrégé: Biomechanics (Basel)
Pays: Switzerland
ID NLM: 101778892
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
medline:
4
9
2023
pubmed:
4
9
2023
entrez:
4
9
2023
Statut:
ppublish
Résumé
Spinal cord injury (SCI) is a profoundly debilitating yet common central nervous system condition resulting in significant morbidity and mortality rates. Major causes of SCI encompass traumatic incidences such as motor vehicle accidents, falls, and sports injuries. Present treatment strategies for SCI aim to improve and enhance neurologic functionality. The ability for neural stem cells (NSCs) to differentiate into diverse neural and glial cell precursors has stimulated the investigation of stem cell scaffolds as potential therapeutics for SCI. Various scaffolding modalities including composite materials, natural polymers, synthetic polymers, and hydrogels have been explored. However, most trials remain largely in the preclinical stage, emphasizing the need to further develop and refine these treatment strategies before clinical implementation. In this review, we delve into the physiological processes that underpin NSC differentiation, including substrates and signaling pathways required for axonal regrowth post-injury, and provide an overview of current and emerging stem cell scaffolding platforms for SCI.
Identifiants
pubmed: 37664542
doi: 10.3390/biomechanics3030028
pmc: PMC10469078
mid: NIHMS1922067
doi:
Types de publication
Journal Article
Langues
eng
Pagination
322-342Subventions
Organisme : NINDS NIH HHS
ID : R25 NS108939
Pays : United States
Déclaration de conflit d'intérêts
Conflicts of Interest: The authors declare no conflict of interest.
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