HCN channel inhibitor induces ketamine-like rapid and sustained antidepressant effects in chronic social defeat stress model.
Antidepressants
Chronic social defeat stress model
HCN channel inhibitor
Ih current
Major depressive disorder
Ventral tegmental area
Journal
Neurobiology of stress
ISSN: 2352-2895
Titre abrégé: Neurobiol Stress
Pays: United States
ID NLM: 101643409
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
11
06
2023
revised:
16
08
2023
accepted:
18
08
2023
medline:
4
9
2023
pubmed:
4
9
2023
entrez:
4
9
2023
Statut:
epublish
Résumé
Repeated, long-term (weeks to months) exposure to standard antidepressant medications is required to achieve treatment efficacy. In contrast, acute ketamine quickly improves mood for an extended time. Recent work implicates that hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are involved in mediating ketamine's antidepressant effects. In this study, we directly targeted HCN channels and achieved ketamine-like rapid and sustained antidepressant efficacy. Our
Identifiants
pubmed: 37664876
doi: 10.1016/j.ynstr.2023.100565
pii: S2352-2895(23)00053-X
pmc: PMC10468802
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100565Informations de copyright
© 2023 The Authors. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
The authors have no conflicts of interests concerning this work.
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