One-year efficacy of a lifestyle behavioural intervention on physical and mental health in people with severe mental disorders: results from a randomized controlled trial.
BMI
Bipolar disorder
Comorbidity
Depression
Framingham Risk score
HOMA-IR index
LIFESTYLE
RCT
Schizophrenia
Waist circumference
Journal
European archives of psychiatry and clinical neuroscience
ISSN: 1433-8491
Titre abrégé: Eur Arch Psychiatry Clin Neurosci
Pays: Germany
ID NLM: 9103030
Informations de publication
Date de publication:
04 Sep 2023
04 Sep 2023
Historique:
received:
05
05
2023
accepted:
14
08
2023
medline:
4
9
2023
pubmed:
4
9
2023
entrez:
4
9
2023
Statut:
aheadofprint
Résumé
This multicentric randomized controlled trial (RCT), carried out in six Italian University mental health sites, aims to test the efficacy of a six-month psychosocial intervention (LYFESTYLE) on Body Mass Index (BMI), body weight, waist circumference, fasting glucose, triglycerides, cholesterol, Framingham and HOmeostasis Model Assessment of insulin resistance (HOMA-IR) indexes in patients with schizophrenia, bipolar disorder, and major depression. Moreover, the efficacy of the intervention has also been tested on several other physical and mental health domains. Patients were randomly allocated to receive the six-month experimental intervention (LIFESTYLE) or a behavioural control intervention. All enrolled patients were assessed at baseline and after one year. We recruited 401 patients (206 in the experimental and 195 in the control group) with a diagnosis of schizophrenia or other psychotic disorder (29.9%), bipolar disorder (43.3%), or major depression (26.9%). At one year, patients receiving the experimental intervention reported an improvement in body mass index, body weight, waist circumference, HOMA-IR index, anxiety and depressive symptoms and in quality of life. Our findings confirm the efficacy of the LIFESTYLE intervention in improving physical and mental health-related outcomes in patients with severe mental illnesses after one year.
Identifiants
pubmed: 37665401
doi: 10.1007/s00406-023-01684-w
pii: 10.1007/s00406-023-01684-w
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministero dell'Università e della Ricerca
ID : 2015C7374S
Investigateurs
Valeria Del Vecchio
(V)
Claudio Malangone
(C)
Emiliana Mancuso
(E)
Claudia Toni
(C)
Antonio Volpicelli
(A)
Ileana Andriola
(I)
Pierluigi Selvaggi
(P)
Martino Belvederi Murri
(M)
Ramona Di Stefano
(R)
Francesca Pacitti
(F)
Valerio Dell'Oste
(V)
Sara Fantasia
(S)
Virginia Pedrinelli
(V)
Giorgio Di Lorenzo
(G)
Cinzia Niolu
(C)
Informations de copyright
© 2023. The Author(s).
Références
Kim H, Turiano NA, Forbes MK, Kotov R, Krueger RF, Eaton NR, Workgroup HU (2021) Internalizing psychopathology and all-cause mortality: a comparison of transdiagnostic vs. diagnosis-based risk prediction. World Psychiatry 20:276–282. https://doi.org/10.1002/wps.20859
doi: 10.1002/wps.20859
pubmed: 34002512
pmcid: 8129836
Correll CU, Solmi M, Croatto G, Schneider LK, Rohani-Montez SC, Fairley L, Smith N, Bitter I, Gorwood P, Taipale H, Tiihonen J (2022) Mortality in people with schizophrenia: a systematic review and meta-analysis of relative risk and aggravating or attenuating factors. World Psychiatry 21:248–271. https://doi.org/10.1002/wps.20994
doi: 10.1002/wps.20994
pubmed: 35524619
pmcid: 9077617
Sampogna G, Di Vincenzo M, Della Rocca B, Mancuso E, Volpicelli A, Perris F, Del Vecchio V, Giallonardo V, Luciano M, Fiorillo A (2022) Physical comorbidities in patients with severe mental disorders: a brief narrative review on current challenges and practical implications for professionals. Riv Psichiatr 57:251–257. https://doi.org/10.1708/3922.39071
doi: 10.1708/3922.39071
pubmed: 36503939
Luciano M, Sampogna G, Amore M, Andriola I, Calcagno P, Carmassi C, Del Vecchio V, Dell’Osso L, Di Lorenzo G, Gelao B, Giallonardo V, Rossi A, Rossi R, Siracusano A, Fiorillo A, LIFESTYLE Working Group (2021) How to improve the physical health of people with severe mental illness? A multicentric randomized controlled trial on the efficacy of a lifestyle group intervention. Eur Psychiatry 64:e72. https://doi.org/10.1192/j.eurpsy.2021.2253
doi: 10.1192/j.eurpsy.2021.2253
pubmed: 34812136
pmcid: 8715281
Suokas K, Hakulinen C, Sund R, Kampman O, Pirkola S (2022) Mortality in persons with recent primary or secondary care contacts for mental disorders in Finland. World Psychiatry 21:470–471. https://doi.org/10.1002/wps.21027
doi: 10.1002/wps.21027
pubmed: 36073698
pmcid: 9453896
De Rosa C, Sampogna G, Luciano M, Del Vecchio V, Pocai B, Borriello G, Giallonardo V, Savorani M, Pinna F, Pompili M, Fiorillo A (2017) Improving physical health of patients with severe mental disorders: a critical review of lifestyle psychosocial interventions. Expert Rev Neurother 17:667–681. https://doi.org/10.1080/14737175.2017
doi: 10.1080/14737175.2017
pubmed: 28468528
Cabassa LJ, Ezell JM, Lewis-Fernández R (2010) Lifestyle interventions for adults with serious mental illness: a systematic literature review. Psychiatr Serv 61:774–782. https://doi.org/10.1176/ps.2010.61.8.774
doi: 10.1176/ps.2010.61.8.774
pubmed: 20675835
pmcid: 3632414
Bradley T, Campbell E, Dray J, Bartlem K, Wye P, Hanly G, Gibson L, Fehily C, Bailey J, Wynne O, Colyvas K, Bowman J (2022) Systematic review of lifestyle interventions to improve weight, physical activity and diet among people with a mental health condition. Syst Rev 11:198. https://doi.org/10.1186/s13643-022-02067-3
doi: 10.1186/s13643-022-02067-3
pubmed: 36085250
pmcid: 9462072
Mucheru D, Hanlon MC, McEvoy M, Thakkinstian A, MacDonald-Wicks L (2019) Comparative efficacy of lifestyle intervention strategies targeting weight outcomes in people with psychosis: a systematic review and network meta-analysis. JBI Database Syst Rev Implement Rep 17:1770–1825. https://doi.org/10.11124/JBISRIR-2017-003943
doi: 10.11124/JBISRIR-2017-003943
Bruins J, Jörg F, Bruggeman R, Slooff C, Corpeleijn E, Pijnenborg M (2014) The effects of lifestyle interventions on (long-term) weight management, cardiometabolic risk and depressive symptoms in people with psychotic disorders: a meta-analysis. PLoS One 9:e112276. https://doi.org/10.1371/journal.pone.0112276
doi: 10.1371/journal.pone.0112276
pubmed: 25474313
pmcid: 4256304
Fernández-San-Martín MI, Martín-López LM, Masa-Font R, Olona-Tabueña N, Roman Y, Martin-Royo J, Oller-Canet S, González-Tejón S, San-Emeterio L, Barroso-Garcia A, Viñas-Cabrera L, Flores-Mateo G (2014) The effectiveness of lifestyle interventions to reduce cardiovascular risk in patients with severe mental disorders: meta-analysis of intervention studies. Commun Ment Health J 50:81–95. https://doi.org/10.1007/s10597-013-9614-6
doi: 10.1007/s10597-013-9614-6
Grundy SM (2005) Metabolic syndrome: therapeutic considerations. Handb Exp Pharmacol 170:107–133. https://doi.org/10.1007/3-540-27661-0_3
doi: 10.1007/3-540-27661-0_3
Bonfioli E, Berti L, Goss C, Muraro F, Burti L (2012) 2012 Health promotion lifestyle interventions for weight management in psychosis: a systematic review and meta-analysis of randomised controlled trials. BMC Psychiatry 12:78. https://doi.org/10.1186/1471-244X-12-78
doi: 10.1186/1471-244X-12-78
pubmed: 22789023
pmcid: 3549787
Foguet-Boreu Q, Fernandez San Martin MI, Flores Mateo G, Zabaleta Del Olmo E, Ayerbe García-Morzon L, Perez-Piñar López M, Martin-López LM, Montes Hidalgo J, Violán C (2016) Cardiovascular risk assessment in patients with a severe mental illness: a systematic review and meta-analysis. BMC Psychiatry 16:141. https://doi.org/10.1186/s12888-016-0833-6
doi: 10.1186/s12888-016-0833-6
pubmed: 27176477
pmcid: 4866037
Lang JJ, McNeil J, Tremblay MS, Saunders TJ (2015) Sit less, stand more: A randomized point-of-decision prompt intervention to reduce sedentary time. Prev Med 73:67–69. https://doi.org/10.1016/j.ypmed.2015.01.026
doi: 10.1016/j.ypmed.2015.01.026
pubmed: 25660483
Penedo FJ, Dahn JR (2005) Exercise and well-being: a review of mental and physical health benefits associated with physical activity. Curr Opin Psychiatry 18:189–193. https://doi.org/10.1097/00001504-200503000-00013
doi: 10.1097/00001504-200503000-00013
pubmed: 16639173
Ross CE, Hayes D (1988) Exercise and psychologic well-being in the community. Am J Epidemiol 127:762–771. https://doi.org/10.1093/oxfordjournals.aje.a114857
doi: 10.1093/oxfordjournals.aje.a114857
pubmed: 3258471
Rosenbaum S, Tiedemann A, Ward PB, Curtis J, Sherrington C (2015) Physical activity interventions: an essential component in recovery from mental illness. Br J Sports Med 49:1544–1545. https://doi.org/10.1136/bjsports-2014-094314
doi: 10.1136/bjsports-2014-094314
pubmed: 25807153
Højlund M, Andersen K, Ernst MT, Correll CU, Hallas J (2022) Use of low-dose quetiapine increases the risk of major adverse cardiovascular events: results from a nationwide active comparator-controlled cohort study. World Psychiatry 21:444–451. https://doi.org/10.1002/wps.21010
doi: 10.1002/wps.21010
pubmed: 36073694
pmcid: 9453914
Beebe LH, Tian L, Morris N, Goodwin A, Allen SS, Kuldau J (2005) Effects of exercise on mental and physical health parameters of persons with schizophrenia. Issues Ment Health Nurs 26:661–676. https://doi.org/10.1080/01612840590959551
doi: 10.1080/01612840590959551
pubmed: 16020076
Rimes RR, de Souza Moura AM, Lamego MK, de Sá Filho AS, Manochio J, Paes F, Carta MG, Mura G, Wegner M, Budde H, Ferreira Rocha NB, Rocha J, Tavares JM, Arias-Carrión O, Nardi AE, Yuan TF, Machado S (2015) Effects of exercise on physical and mental health, and cognitive and brain functions in schizophrenia: clinical and experimental evidence. CNS Neurol Disord Drug Targets 14:1244–1254. https://doi.org/10.2174/1871527315666151111130659
doi: 10.2174/1871527315666151111130659
pubmed: 26556069
Scheewe TW, Backx FJ, Takken T, Jörg F, van Strater AC, Kroes AG, Kahn RS, Cahn W (2013) Exercise therapy improves mental and physical health in schizophrenia: a randomised controlled trial. Acta Psychiatr Scand 127:464–473. https://doi.org/10.1111/acps.12029
doi: 10.1111/acps.12029
pubmed: 23106093
Acil AA, Dogan S, Dogan O (2002) The effects of physical exercises to mental state and quality of life in patients with schizophrenia. J Psychiatr Ment Health Nurs 15:808–815. https://doi.org/10.1111/j.1365-2850.2008.01317.x
doi: 10.1111/j.1365-2850.2008.01317.x
Wipfli BM, Rethorst CD, Landers DM (2008) The anxiolytic effects of exercise: a meta-analysis of randomized trials and dose-response analysis. J Sport Exerc Psychol 30:392–410. https://doi.org/10.1123/jsep.30.4.392
doi: 10.1123/jsep.30.4.392
pubmed: 18723899
American Psychiatric Association (2013) Structured Clinical Interview for DSM-5 (SCID-5). American Psychiatric Association publishing
World Health Organization (2010) Global Recommendations on Physical Activity for Health
World Health Organization (2013)Global Action Plan for the Prevention and Control of NCDs 2013–2020
Rydén L, Grant PJ, Anker SD, Berne C, Cosentino F, Danchin N et al (2013) ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD: the Task Force on diabetes, prediabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and developed in collaboration with the European Association for the Study of Diabetes (EASD). Eur Heart J 34:3035–3087. https://doi.org/10.1093/eurheartj/eht108
doi: 10.1093/eurheartj/eht108
pubmed: 23996285
Piepoli MF, Hoes AW, Agewall S, Albus C, Brotons C, Catapano AL et al (2016) European Guidelines on cardiovascular disease prevention in clinical practice: The sixth joint task force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of 10 societies and by invited experts) developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR). Atherosclerosis 252:207–274. https://doi.org/10.1093/eurheartj/ehw106
doi: 10.1093/eurheartj/ehw106
pubmed: 27664503
De Hert M, Dekker JM, Wood D, Kahl KG, Holt RI, Möller HJ (2009) Cardiovascular disease and diabetes in people with severe mental illness position statement from the European Psychiatric Association (EPA), supported by the European Association for the Study of Diabetes (EASD) and the European Society of Cardiology (ESC). Eur Psychiatry 24:412–424. https://doi.org/10.1016/j.eurpsy.2009.01.005
doi: 10.1016/j.eurpsy.2009.01.005
pubmed: 19682863
Sampogna G, Fiorillo A, Luciano M, Del Vecchio V, Steardo L Jr, Pocai B, Barone M, Amore M, Pacitti F, Dell’Osso L, Di Lorenzo G, Maj M, LIFESTYLE Working Group (2018) A Randomized controlled trial on the efficacy of a psychosocial behavioral intervention to improve the lifestyle of patients with severe mental disorders: study protocol. Front Psychiatry 9:235. https://doi.org/10.3389/fpsyt.2018.00235
doi: 10.3389/fpsyt.2018.00235
pubmed: 29930520
pmcid: 6001842
Luciano M, Sampogna G, Amore M, Bertolino A, Dell’Osso L, Rossi A, Siracusano A, Calcagno P, Carmassi C, Di Lorenzo G, Di Vincenzo M, Giallonardo V, Rampino A, Rossi R, LIFESTYLE Working Group, Fiorillo A (2022) Improving physical activity and diet in patients with severe mental disorders: Results from the LIFESTYLE multicentric, real-world randomized controlled trial. Psychiatry Res 317:114818. https://doi.org/10.1016/j.psychres.2022.114818
doi: 10.1016/j.psychres.2022.114818
pubmed: 36088834
Fiorillo A, Del Vecchio V, Luciano M, Sampogna G, De Rosa C, Malangone C, Volpe U, Bardicchia F, Ciampini G, Crocamo C, Iapichino S, Lampis D, Moroni A, Orlandi E, Piselli M, Pompili E, Veltro F, Carrà G, Maj M (2015) Efficacy of psychoeducational family intervention for bipolar I disorder: a controlled, multicentric, real-world study. J Affect Disord 172:291–299
doi: 10.1016/j.jad.2014.10.021
pubmed: 25451428
Lukoff D, Nuechterlein KH, Ventura J (1986) Appendix A: manual for expanded Brief Psychiatric Rating Scale (BPRS). Schizophr Bull 12:594–602
Morosini PL, Magliano L, Brambilla L, Ugolini S, Pioli R (2000) Development, reliability and acceptability of a new version of the DSM-IV Social and Occupational Functioning Assessment Scale (SOFAS) to assess routine social functioning. Acta Psychiatr Scand 101:323–329
doi: 10.1111/j.1600-0447.2000.tb10933.x
pubmed: 10782554
Priebe S, Huxley P, Knight S, Evans S (1999) Application and results of the Manchester Short Assessment of Quality of Life (MANSA). Int J Soc Psychiatry 45:7–12
doi: 10.1177/002076409904500102
pubmed: 10443245
Kern RS, Nuechterlein KH, Green MF, Baade LE, Fenton WS, Gold JM et al (2008) The MATRICS consensus cognitive battery, part 2: co-norming and standardization. Am J Psychiatry 165:214–220
doi: 10.1176/appi.ajp.2007.07010043
pubmed: 18172018
Nuechterlein KH, Green MF, Kern RS, Baade LE, Barch DM, Cohen JD et al (2008) The MATRICS consensus cognitive battery, part 1: test selection, reliability, and validity. Am J Psychiatry 165:203–213
doi: 10.1176/appi.ajp.2007.07010042
pubmed: 18172019
Shafer A (2005) Meta-analysis of the brief psychiatric rating scale factor structure. Psychol Assess 2005(17):324–335. https://doi.org/10.1037/1040-3590.17.3.324
doi: 10.1037/1040-3590.17.3.324
Linn BS, Linn MW, Gurel L (1968) Cumulative illness rating scale. J Am Geriatr Soc 8(16):622–626
doi: 10.1111/j.1532-5415.1968.tb02103.x
Freeman AM, Pennings N (2021) Insulin Resistance. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing
Foguet-Boreu Q, Ayerbe G-M (2021) Psychosocial stress, high blood pressure and cardiovascular risk. Hipertens Riesgo Vasc 38:83–90. https://doi.org/10.1016/j.hipert.2020.09.001
doi: 10.1016/j.hipert.2020.09.001
pubmed: 33060048
Ayerbe L, Forgnone I, Foguet-Boreu Q, González E, Addo J, Ayis S (2018) Disparities in the management of cardiovascular risk factors in patients with psychiatric disorders: a systematic review and meta-analysis. Psychol Med 48:2693–2701. https://doi.org/10.1017/S0033291718000302
doi: 10.1017/S0033291718000302
pubmed: 29490716
Daumit GL, Dalcin AT, Dickerson FB, Miller ER, Evins AE, Cather C, Jerome GJ, Young DR, Charleston JB, Gennusa JV 3rd, Goldsholl S, Cook C, Heller A, McGinty EE, Crum RM, Appel LJ, Wang NY (2020) Effect of a comprehensive cardiovascular risk reduction intervention in persons with serious mental illness: a randomized clinical trial. JAMA Netw Open 2020(3):e207247. https://doi.org/10.1001/jamanetworkopen.2020.7247
doi: 10.1001/jamanetworkopen.2020.7247
Ma J, Berra K, Haskell WL, Klieman L, Hyde S, Smith MW, Xiao L, Stafford RS (2009) Case management to reduce risk of cardiovascular disease in a county health care system. Arch Intern Med 169:1988–1995. https://doi.org/10.1001/archinternmed.2009.381
doi: 10.1001/archinternmed.2009.381
pubmed: 19933961
pmcid: 3000904
Lönnberg L, Ekblom-Bak E, Damberg M (2020) Reduced 10-year risk of developing cardiovascular disease after participating in a lifestyle programme in primary care. Ups J Med Sci 125:250–256. https://doi.org/10.1080/03009734.2020.1726533
doi: 10.1080/03009734.2020.1726533
pubmed: 32077778
pmcid: 7720946
Ross R, Neeland IJ, Yamashita S, Shai I, Seidell J, Magni P, Santos RD, Arsenault B, Cuevas A, Hu FB, Griffin BA, Zambon A, Barter P, Fruchart JC, Eckel RH, Matsuzawa Y, Després JP (2020) Waist circumference as a vital sign in clinical practice: a consensus statement from the IAS and ICCR working group on visceral obesity. Nat Rev Endocrinol 16:177–189
doi: 10.1038/s41574-019-0310-7
pubmed: 32020062
pmcid: 7027970
Ritunnano R, Stanghellini G, Broome MR (2021) Self-interpretation and meaning-making processes: re-humanizing research on early psychosis. World Psychiatry 20:304–306. https://doi.org/10.1002/wps.20878
doi: 10.1002/wps.20878
pubmed: 34002514
pmcid: 8129842
Swift JK, Mullins RH, Penix EA, Roth KL, Trusty WT (2021) The importance of listening to patient preferences when making mental health care decisions. World Psychiatry 20:316–317. https://doi.org/10.1002/wps.20912
doi: 10.1002/wps.20912
pubmed: 34505382
pmcid: 8429341
Wakefield JC (2022) Klerman’s “credo” reconsidered: neo-Kraepelinianism, Spitzer’s views, and what we can learn from the past. World Psychiatry 21:4–25. https://doi.org/10.1002/wps.20942
doi: 10.1002/wps.20942
pubmed: 35015356
pmcid: 8751581
Schuch HS, Peres KG, Haag DG, Boing AF, Peres MA (2022) The independent and joint contribution of objective and subjective socioeconomic status on oral health indicators. Commun Dent Oral Epidemiol 50:570–578. https://doi.org/10.1111/cdoe.12715
doi: 10.1111/cdoe.12715
Penninx BWJH (2021) Psychiatric symptoms and cognitive impairment in “Long COVID”: the relevance of immunopsychiatry. World Psychiatry 20:357–358. https://doi.org/10.1002/wps.20913
doi: 10.1002/wps.20913
pubmed: 34505378
pmcid: 8429338
Thornicroft G (2022) Psychiatric diagnosis and treatment in the 21st century: paradigm shifts or power shifts? World Psychiatry 2022(21):334–335. https://doi.org/10.1002/wps.21000
doi: 10.1002/wps.21000
Valtorta NK, Kanaan M, Gilbody S, Hanratty B (2018) Loneliness, social isolation and risk of cardiovascular disease in the English Longitudinal Study of Ageing. Eur J Prev Cardiol 25:1387–1396
doi: 10.1177/2047487318792696
pubmed: 30068233
Maj M, van Os J, De Hert M, Gaebel W, Galderisi S, Green MF, Guloksuz S, Harvey PD, Jones PB, Malaspina D, McGorry P, Miettunen J, Murray RM, Nuechterlein KH, Peralta V, Thornicroft G, van Winkel R, Ventura J (2021) The clinical characterization of the patient with primary psychosis aimed at personalization of management. World Psychiatry 20:4–33. https://doi.org/10.1002/wps.20809
doi: 10.1002/wps.20809
pubmed: 33432763
pmcid: 7801854
Stein DJ, Craske MG, Rothbaum BO, Chamberlain SR, Fineberg NA, Choi KW, de Jonge P, Baldwin DS, Maj M (2021) The clinical characterization of the adult patient with an anxiety or related disorder aimed at personalization of management. World Psychiatry 20:336–356. https://doi.org/10.1002/wps.20919
doi: 10.1002/wps.20919
pubmed: 34505377
pmcid: 8429350
McIntyre RS, Alda M, Baldessarini RJ, Bauer M, Berk M, Correll CU, Fagiolini A, Fountoulakis K, Frye MA, Grunze H, Kessing LV, Miklowitz DJ, Parker G, Post RM, Swann AC, Suppes T, Vieta E, Young A, Maj M (2022) The clinical characterization of the adult patient with bipolar disorder aimed at personalization of management. World Psychiatry 21:364–387. https://doi.org/10.1002/wps.20997
doi: 10.1002/wps.20997
pubmed: 36073706
pmcid: 9453915
Fabiano N, Gupta A, Fiedorowicz JG, Firth J, Stubbs B, Vancampfort D, Schuch FB, Carr LJ, Solmi M (2023) The effect of exercise on suicidal ideation and behaviors: A systematic review and meta-analysis of randomized controlled trials. J Affect Disord 330:355–366. https://doi.org/10.1016/j.jad.2023.02.071
doi: 10.1016/j.jad.2023.02.071
pubmed: 36871911
Sampasa-Kanyinga H, Hamilton HA (2016) Does socioeconomic status moderate the relationships between school connectedness with psychological distress, suicidal ideation and attempts in adolescents? Prev Med 87:11–17. https://doi.org/10.1016/j.ypmed.2016.02.010
doi: 10.1016/j.ypmed.2016.02.010
pubmed: 26876628
Kleppang AL, Haugland SH, Bakken A, Stea TH (2021) Lifestyle habits and depressive symptoms in Norwegian adolescents: a national cross-sectional study. BMC Public Health 21:816. https://doi.org/10.1186/s12889-021-10846-1
doi: 10.1186/s12889-021-10846-1
pubmed: 33910539
pmcid: 8082771
Wang R, Zhang H, Li H, Ren H, Sun T, Xu L, Liu Y, Hou X (2022) The influence of exercise interventions on cognitive functions in patients with amnestic mild cognitive impairment: A systematic review and meta-analysis. Front Public Health 10:1046841. https://doi.org/10.3389/fpubh.2022.1046841
doi: 10.3389/fpubh.2022.1046841
pubmed: 36457329
pmcid: 9706097
Allgulander C (2016) Anxiety as a risk factor in cardiovascular disease. Curr Opin Psychiatry 29:13–17. https://doi.org/10.1097/YCO.0000000000000217
doi: 10.1097/YCO.0000000000000217
pubmed: 26575295
Jacobs S, Hann M, Bradley F, Elvey R, Fegan T, Halsall D, Hassell K, Wagner A, Schafheutle EI (2020) Organisational factors associated with safety climate, patient satisfaction and self-reported medicines adherence in community pharmacies. Res Social Adm Pharm 16:895–903. https://doi.org/10.1016/j.sapharm.2019.09.058
doi: 10.1016/j.sapharm.2019.09.058
pubmed: 31558413
Fiorillo A, Carpiniello B, De Giorgi S, La Pia S, Maina G, Sampogna G, Spina E, Tortorella A, Vita A (2018) Assessment and management of cognitive and psychosocial dysfunctions in patients with major depressive disorder: a clinical review. Front Psychiatry 2018(9):493. https://doi.org/10.3389/fpsyt.2018.00493
doi: 10.3389/fpsyt.2018.00493
Speyer H, Nørgaard HC, Hjorthøj C, Madsen TA, Drivsholm S, Pisinger C, Gluud C, Mors O, Krogh J, Nordentoft M (2015) Protocol for CHANGE: a randomized clinical trial assessing lifestyle coaching plus care coordination versus care coordination alone versus treatment as usual to reduce risks of cardiovascular disease in adults with schizophrenia and abdominal obesity. BMC Psychiatry 23(15):119. https://doi.org/10.1186/s12888-015-0465-2
doi: 10.1186/s12888-015-0465-2
Fiorillo A, Del Vecchio V, Luciano M, Sampogna G, Sbordone D, Catapano F, De Rosa C, Malangone C, Tortorella A, Veltro F, Nicolò G, Piselli M, Bardicchia F, Ciampini G, Lampis D, Moroni A, Bassi M, Iapichino S, Biondi S, Graziani A, Orlandi E, Starace F, Baronessa C, Carrà G, Maj M (2016) Feasibility of a psychoeducational family intervention for people with bipolar I disorder and their relatives: results from an Italian real-world multicentre study. J Affect Disord 15(190):657–662
doi: 10.1016/j.jad.2015.10.060
Torous J, Bucci S, Bell IH, Kessing LV, Faurholt-Jepsen M, Whelan P, Carvalho AF, Keshavan M, Linardon J, Firth J (2021) The growing field of digital psychiatry: current evidence and the future of apps, social media, chatbots, and virtual reality. World Psychiatry 20:318–335. https://doi.org/10.1002/wps.20883
doi: 10.1002/wps.20883
pubmed: 34505369
pmcid: 8429349
Stein DJ, Shoptaw SJ, Vigo DV, Lund C, Cuijpers P, Bantjes J, Sartorius N, Maj M (2022) Psychiatric diagnosis and treatment in the 21st century: paradigm shifts versus incremental integration. World Psychiatry 21:393–414. https://doi.org/10.1002/wps.20998
doi: 10.1002/wps.20998
pubmed: 36073709
pmcid: 9453916
Espie CA, Firth J, Torous J (2022) Evidence-informed is not enough: digital therapeutics also need to be evidence-based. World Psychiatry 21:320–321. https://doi.org/10.1002/wps.20993
doi: 10.1002/wps.20993
pubmed: 35524617
pmcid: 9077620
Wasil AR, Gillespie S, Schell T, Lorenzo-Luaces L, DeRubeis RJ (2021) Estimating the real-world usage of mobile apps for mental health: development and application of two novel metrics. World Psychiatry 20:137–138. https://doi.org/10.1002/wps.20827
doi: 10.1002/wps.20827
pubmed: 33432761
pmcid: 7801857