Associations of Serum testosterone and sex hormone-binding globulin with incident Arrhythmias in men from UK Biobank.

Sex hormones have been identified as cardiovascular risk factors, while the relationship between sex hormones and the risk of arrhythmias in men has not yet been well studied in the prospective cohort study. To analyze associations of serum testosterone, sex hormone-binding globulin (SHBG) concentrations and calculated free testosterone (cFT) with arrhythmias in men. Sex hormones were measured at baseline from UK Biobank. Main outcomes were incidence of atrial fibrillation/flutter (AF), ventricular arrhythmia (VA), bradyarrhythmia (BA). Of 173 498 men (aged 37 to 73 years, followed for 11 years), 11 368 had incident AF, 1 646 had incident VA, and 4 788 had incident BA. Compared with the third quartiles, the lowest category of serum testosterone was associated with increased risks of AF (HR 1.06, 95% CI 1.00-1.12) and BA (HR 1.11, 95% CI 1.02-1.20) after multivariable adjustment, but no VA. Likewise, similar associations were found between cFT values and AF and BA events. Furthermore, higher levels of cFT were associated with increased risks of AF (HR 1.07, 95% CI 1.02-1.13) and VA (HR 1.18, 95% CI 1.01-1.37). Higher SHBG concentrations were associated with increased risks of AF (HR 1.44, 95% CI 1.34-1.54), VA (HR 1.27, 95% CI 1.07-1.52), and BA (HR 1.17, 95% CI 1.05-1.29). Lower levels of testosterone and cFT were associated with increased risk of AF and BA. Higher cFT levels were associated with increased risk of AF and VA. Higher SHBG levels were associated with increased risk of AF, VA, and BA.

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