ZFH-2 is required for Drosophila ovarian follicle development and is expressed at the band/interband boundaries of polytene chromosomes.
CP190
Daughterless
Oogenesis
Springer retrotransposon
ZFH-2
Journal
Developmental biology
ISSN: 1095-564X
Titre abrégé: Dev Biol
Pays: United States
ID NLM: 0372762
Informations de publication
Date de publication:
12 2023
12 2023
Historique:
received:
06
04
2023
revised:
29
08
2023
accepted:
01
09
2023
medline:
6
11
2023
pubmed:
5
9
2023
entrez:
4
9
2023
Statut:
ppublish
Résumé
The transcription factor ZFH-2 has well-documented roles in Drosophila neurogenesis and other developmental processes. Here we provide the first evidence that ZFH-2 has a role in oogenesis. We demonstrate that ZFH-2 is expressed in the wild-type ovary and that a loss of zfh-2 function produces a mutant ovary phenotype where egg chambers are reduced in number and fused. We also show that a loss of zfh-2 function can suppress a daughterless loss-of-function ovary phenotype suggesting a possible genetic relationship between these two genes in the ovary. We also show that ZFH-2 is located at the boundary between bands and interbands on polytene chromosomes and that at a subset of these sites ZFH-2 colocalizes with the insulator/promoter cofactor CP190.
Identifiants
pubmed: 37666353
pii: S0012-1606(23)00147-1
doi: 10.1016/j.ydbio.2023.09.001
pii:
doi:
Substances chimiques
CP190 protein, Drosophila
0
Drosophila Proteins
0
Microtubule-Associated Proteins
0
Nuclear Proteins
0
Zfh2 protein, Drosophila
143066-63-1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-11Subventions
Organisme : NCRR NIH HHS
ID : G12 RR013646
Pays : United States
Organisme : NIMHD NIH HHS
ID : G12 MD007591
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.