In vitro studies of manganese transport and homeostasis.
Genetics
Manganese
SLC39A8
Transporter
Journal
Methods in enzymology
ISSN: 1557-7988
Titre abrégé: Methods Enzymol
Pays: United States
ID NLM: 0212271
Informations de publication
Date de publication:
2023
2023
Historique:
medline:
6
9
2023
pubmed:
5
9
2023
entrez:
4
9
2023
Statut:
ppublish
Résumé
Manganese (Mn) is an essential micronutrient required for fundamental cell functions and vital physiological processes. More than a dozen putative Mn transporters have been described over the last two decades, but few have been thoroughly evaluated. Recent genetic studies have revealed vital roles for solute carrier family 39, member 8 (SLC39A8) in Mn homeostasis. SLC39A8 can mediate the cellular uptake of the essential metals zinc, iron, and Mn, as well as the non-essential metal cadmium. However, loss-of-function mutations in SLC39A8 have been found in patients with severe Mn deficiency in the blood without affecting other metals. An in vitro study from our laboratory showed that SLC39A8 is a cell-surface transporter that strongly stimulates
Identifiants
pubmed: 37666632
pii: S0076-6879(23)00161-1
doi: 10.1016/bs.mie.2023.04.023
pii:
doi:
Substances chimiques
Manganese
42Z2K6ZL8P
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
185-206Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK123022
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS112974
Pays : United States
Informations de copyright
Copyright © 2023. Published by Elsevier Inc.