[Alterations of β-γ coupling of scalp electroencephalography during epilepsy].

Uncovering the alterations of neural interactions within the brain during epilepsy is important for the clinical diagnosis and treatment. Previous studies have shown that the phase-amplitude coupling (PAC) can be used as a potential biomarker for locating epileptic zones and characterizing the transition of epileptic phases. However, in contrast to the θ-γ coupling widely investigated in epilepsy, few studies have paid attention to the β-γ coupling, as well as its potential applications. In the current study, we use the modulation index (MI) to calculate the scalp electroencephalography (EEG)-based β-γ coupling and investigate the corresponding changes during different epileptic phases. The results show that the β-γ coupling of each brain region changes with the evolution of epilepsy, and in several brain regions, the β-γ coupling decreases during the ictal period but increases in the post-ictal period, where the differences are statistically significant. Moreover, the alterations of β-γ coupling between different brain regions can also be observed, and the strength of β-γ coupling increases in the post-ictal period, where the differences are also significant. Taken together, these findings not only contribute to understanding neural interactions within the brain during the evolution of epilepsy, but also provide a new insight into the clinical treatment. 揭示癫痫过程中脑内信息交互变化对临床诊疗具有重要意义。早期研究表明，相位-幅度耦合（PAC）可作为定位致痫区域和表征癫痫状态转换的潜在生物标志物。然而，目前癫痫的相位-幅度耦合研究多集中于θ-γ耦合，对β-γ耦合在癫痫过程中的变化及潜在应用知之甚少。对此，本文基于癫痫头皮脑电（EEG）数据，采用调节指数（MI）的PAC方法，探究癫痫不同状态下β-γ耦合的变化。结果发现，癫痫过程中各脑区内β-γ耦合随状态发生改变，多数脑区内的β-γ耦合在发作期减小，在发作后期增加，其差异具有统计学意义。癫痫过程中不同脑区间也存在β-γ耦合，且β-γ耦合强度在发作后期增加，其差异具有统计学意义。这些研究结果既有助于理解癫痫过程中脑内信息交互的改变，也为癫痫的临床诊疗提供了新参考。.