Physical function and mental health trajectories in COVID-19 patients following invasive mechanical ventilation: a prospective observational study.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
04 09 2023
04 09 2023
Historique:
received:
17
11
2022
accepted:
30
08
2023
medline:
6
9
2023
pubmed:
5
9
2023
entrez:
4
9
2023
Statut:
epublish
Résumé
This prospective observational cohort study was performed to investigate the physical function and mental health trajectories of novel coronavirus disease 2019 (COVID-19) patients requiring invasive mechanical ventilation (IMV) after discharge from the intensive care unit (ICU). The study population consisted of 64 patients (median age, 60 years; 85.9% male; median IMV duration, 9 days). At ICU discharge, 28.1% of the patients had Medical Research Council (MRC) sum score < 48 points, and prolonged IMV was significantly associated with lower MRC sum score and handgrip strength. Symptoms were similar between groups at ICU discharge, and the symptoms most commonly reported as moderate-to-severe were impaired well-being (52%), anxiety (43%), tiredness (41%), and depression (35%). Although muscle strength and mobility status were significantly improved after ICU discharge, Edmonton Symptom Assessment System score did not improve significantly in the prolonged IMV group. EuroQol five-dimension five-level summary index was significantly lower in the prolonged than short IMV group at 6 months after ICU discharge. We found substantial negative physical function and mental health consequences in the majority of surviving COVID-19 patients requiring IMV, with prolonged period of IMV showing greater negative effects not only immediately but also at 6 months after discharge from the ICU.
Identifiants
pubmed: 37666912
doi: 10.1038/s41598-023-41684-3
pii: 10.1038/s41598-023-41684-3
pmc: PMC10477337
doi:
Types de publication
Observational Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
14529Informations de copyright
© 2023. Springer Nature Limited.
Références
WHO. WHO coronavirus disease (COVID-19) dashboard. https://covid19.who.int/ (accessed July 30, 2022).
Lim, Z. J. & Subramaniam, A. Case fatality rates for patients with COVID-19 requiring invasive mechanical ventilation. A meta-analysis. Am. J. Respir. Crit. Care Med. 203, 54–66 (2021).
pubmed: 33119402
pmcid: 7781141
doi: 10.1164/rccm.202006-2405OC
Botta, M. et al. Ventilation management and clinical outcomes in invasively ventilated patients with COVID-19 (PRoVENT-COVID): A national, multicentre, observational cohort study. Lancet Respir. Med. 9, 139–148 (2021).
pubmed: 33169671
doi: 10.1016/S2213-2600(20)30459-8
Herridge, M. S. et al. Functional disability 5 years after acute respiratory distress syndrome. N. Engl. J. Med. 364, 1293–1304 (2011).
pubmed: 21470008
doi: 10.1056/NEJMoa1011802
Hamilton, M. et al. Determinants of depressive symptoms at 1 year following ICU discharge in survivors of ≥ 7 days of mechanical ventilation: Results from the recover program, a secondary analysis of a prospective multicenter cohort study. Chest 156, 466–476 (2019).
pubmed: 31102611
doi: 10.1016/j.chest.2019.04.104
Hermans, G. & Van den Berghe, G. Clinical review: Intensive care unit acquired weakness. Crit. Care 19, 274 (2015).
pubmed: 26242743
pmcid: 4526175
doi: 10.1186/s13054-015-0993-7
McWilliams, D. & Weblin, J. Rehabilitation levels in patients with COVID-19 admitted to intensive care requiring invasive ventilation. An observational study. Ann. Am. Thorac. Soc. 18, 122–129 (2021).
pubmed: 32915072
pmcid: 7780973
doi: 10.1513/AnnalsATS.202005-560OC
van Gassel, R. J. J. et al. Functional outcomes and their association with physical performance in mechanically ventilated coronavirus disease 2019 Survivors at 3 months following hospital discharge: A cohort study. Crit. Care Med. 49, 1726–1738 (2021).
pubmed: 33967204
pmcid: 8439632
doi: 10.1097/CCM.0000000000005089
Maley, J. H. et al. Six-month impairment in cognition, mental health, and physical function following COVID-19-associated respiratory failure. Crit. Care Explor. 4, e0673 (2022).
pubmed: 35372848
pmcid: 8963828
doi: 10.1097/CCE.0000000000000673
Evans, R. A. et al. Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): A UK multicentre, prospective cohort study. Lancet Respir. Med. 9, 1275–1287 (2021).
pubmed: 34627560
pmcid: 8497028
doi: 10.1016/S2213-2600(21)00383-0
Kasugai, D., Ozaki, M. & Nishida, K. Usefulness of respiratory mechanics and laboratory parameter trends as markers of early treatment success in mechanically ventilated severe coronavirus disease: A single-center pilot study. J. Clin. Med. 10, 2513 (2021).
pubmed: 34204119
pmcid: 8201161
doi: 10.3390/jcm10112513
Marra, A., Ely, E. W., Pandharipande, P. P. & Patel, M. B. The ABCDEF bundle in critical care. Crit. Care Clin. 33, 225–243 (2017).
pubmed: 28284292
pmcid: 5351776
doi: 10.1016/j.ccc.2016.12.005
Knight, S. R. et al. Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO clinical characterisation protocol: Development and validation of the 4C mortality score. BMJ 370, m3339 (2020).
pubmed: 32907855
doi: 10.1136/bmj.m3339
Rockwood, K. et al. A global clinical measure of fitness and frailty in elderly people. CMAJ 173, 489–495 (2005).
pubmed: 16129869
pmcid: 1188185
doi: 10.1503/cmaj.050051
Fossat, G. et al. Effect of in-bed leg cycling and electrical stimulation of the quadriceps on global muscle strength in critically Ill adults: A randomized clinical trial. JAMA 320, 368–378 (2018).
pubmed: 30043066
pmcid: 6583091
doi: 10.1001/jama.2018.9592
Schefold, J. C. et al. Muscular weakness and muscle wasting in the critically ill. J. Cachexia Sarcopenia Muscle 11, 1399–1412 (2020).
pubmed: 32893974
pmcid: 7749542
doi: 10.1002/jcsm.12620
Satake, S. & Arai, H. The revised Japanese version of the cardiovascular health study criteria (revised J-CHS criteria). Geriatr. Gerontol. Int. 20, 992–993 (2020).
pubmed: 33003255
doi: 10.1111/ggi.14005
Ono, K. et al. Myelopathy hand. New clinical signs of cervical cord damage. J. Bone Joint. Surg. Br. 69, 215–219 (1987).
pubmed: 3818752
doi: 10.1302/0301-620X.69B2.3818752
Numasawa, T. et al. Simple foot tapping test as a quantitative objective assessment of cervical myelopathy. Spine Phila Pa 1976(37), 108–113 (2012).
doi: 10.1097/BRS.0b013e31821041f8
Richardson, L. A. & Jones, G. W. A review of the reliability and validity of the edmonton symptom assessment system. Curr. Oncol. 16, 55 (2009).
pubmed: 19229371
pmcid: 2644623
doi: 10.3747/co.v16i1.261
Selby, D. et al. A single set of numerical cutpoints to define moderate and severe symptoms for the edmonton symptom assessment system. J. Pain Symptom Manag. 39, 241–249 (2010).
doi: 10.1016/j.jpainsymman.2009.06.010
Hodgson, C. et al. Feasibility and inter-rater reliability of the ICU Mobility Scale. Hear. Lung 43, 19–24 (2014).
doi: 10.1016/j.hrtlng.2013.11.003
Herdman, M. et al. Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L). Qual. Life Res. 20, 1727–1736 (2011).
pubmed: 21479777
pmcid: 3220807
doi: 10.1007/s11136-011-9903-x
Shiroiwa, T. et al. Comparison of value set based on DCE and/or TTO data: Scoring for EQ-5D-5L health states in Japan. Value Health 19, 648–654 (2016).
pubmed: 27565282
doi: 10.1016/j.jval.2016.03.1834
Navaratnam, A. V., Gray, W. K., Day, J., Wendon, J. & Briggs, T. W. R. Patient factors and temporal trends associated with COVID-19 in-hospital mortality in England: An observational study using administrative data. Lancet Respir. Med. 9, 397–406 (2021).
pubmed: 33600777
pmcid: 7906650
doi: 10.1016/S2213-2600(20)30579-8
Le Terrier, C. et al. Early prone positioning in acute respiratory distress syndrome related to COVID-19: A propensity score analysis from the multicentric cohort COVID-ICU network-the ProneCOVID study. Crit. Care 26, 71 (2022).
pubmed: 35331332
pmcid: 8944409
doi: 10.1186/s13054-022-03949-7
Tanaka, C. et al. Association between mortality and age among mechanically ventilated COVID-19 patients: A Japanese nationwide COVID-19 database study. Ann. Intensive Care 11, 171 (2021).
pubmed: 34897587
pmcid: 8665852
doi: 10.1186/s13613-021-00959-6
Irie, H. et al. The Japanese Intensive care patient database (JIPAD): A national intensive care unit registry in Japan. J. Crit. Care 55, 86–94 (2020).
pubmed: 31715536
doi: 10.1016/j.jcrc.2019.09.004
Elliott, D. et al. Exploring the scope of post-intensive care syndrome therapy and care: Engagement of non-critical care providers and survivors in a second stakeholders meeting. Crit. Care Med. 42, 2518–2526 (2014).
pubmed: 25083984
doi: 10.1097/CCM.0000000000000525
Vanhorebeek, I. & Latronico, N. ICU-acquired weakness. Intensive Care Med. 46, 637–653 (2020).
pubmed: 32076765
pmcid: 7224132
doi: 10.1007/s00134-020-05944-4
Appleton, R. T., Kinsella, J. & Quasim, T. The incidence of intensive care unit-acquired weakness syndromes: A systematic review. J. Intensive Care Soc. 16, 126–136 (2015).
pubmed: 28979394
doi: 10.1177/1751143714563016
Garnacho-Montero, J. et al. Critical illness polyneuropathy: risk factors and clinical consequences. A cohort study in septic patients. Intensive Care Med. 27, 1288–1296 (2001).
pubmed: 11511941
doi: 10.1007/s001340101009
Lipshutz, A. K. & Gropper, M. A. Acquired neuromuscular weakness and early mobilization in the intensive care unit. Anesthesiology 118, 202–215 (2013).
pubmed: 22929731
doi: 10.1097/ALN.0b013e31826be693
Huang, L. et al. 1-year outcomes in hospital survivors with COVID-19: A longitudinal cohort study. Lancet 398, 747–758 (2021).
pubmed: 34454673
pmcid: 8389999
doi: 10.1016/S0140-6736(21)01755-4
Steinbeis, F. et al. Severity of respiratory failure and computed chest tomography in acute COVID-19 correlates with pulmonary function and respiratory symptoms after infection with SARS-CoV-2: An observational longitudinal study over 12 months. Respir. Med. 191, 106709 (2022).
pubmed: 34871947
doi: 10.1016/j.rmed.2021.106709
Ollila, H. et al. Long-term cognitive functioning is impaired in ICU-treated COVID-19 patients: A comprehensive controlled neuropsychological study. Crit. Care 26, 223 (2022).
pubmed: 35858899
pmcid: 9297673
doi: 10.1186/s13054-022-04092-z
Stutz, M. R. et al. Early rehabilitation feasibility in a COVID-19 ICU. Chest 160, 2146–2148 (2021).
pubmed: 34116067
pmcid: 8185320
doi: 10.1016/j.chest.2021.05.059
Liu, K. & Nakamura, K. Mobilization and rehabilitation practice in ICUs during the COVID-19 pandemic. J. Intensiv. Care Med. 37(9), 1256–1264 (2022).
doi: 10.1177/08850666221097644
Nakamura, K., Nakano, H., Naraba, H., Mochizuki, M. & Hashimoto, H. Early rehabilitation with dedicated use of belt-type electrical muscle stimulation for severe COVID-19 patients. Crit. Care 24, 342 (2020).
pubmed: 32539827
pmcid: 7294763
doi: 10.1186/s13054-020-03080-5
Johnson, J. K., Lapin, B., Green, K. & Stilphen, M. Frequency of physical therapist intervention is associated with mobility status and disposition at hospital discharge for patients with COVID-19. Phys. Ther. 101, 5896 (2021).
doi: 10.1093/ptj/pzaa181
Büsching, G. & Zhang, Z. Effectiveness of pulmonary rehabilitation in severe and critically Ill COVID-19 patients: A controlled study. Int. J. Environ. Res. Public Health 18, 8956 (2021).
pubmed: 34501549
pmcid: 8430691
doi: 10.3390/ijerph18178956
Everaerts, S., Heyns, A., Langer, D., Beyens, H. & Hermans, G. COVID-19 recovery: benefits of multidisciplinary respiratory rehabilitation. BMJ Open Respir. Res. 8, e000837 (2021).
pubmed: 34489236
doi: 10.1136/bmjresp-2020-000837