Similarities in the induction of the intracellular pathogen response in Caenorhabditis elegans and the type I interferon response in mammals.
C. elegans
RIG-I-like receptor
development
epithelial immunity
interferon
proteasome
purine metabolism
Journal
BioEssays : news and reviews in molecular, cellular and developmental biology
ISSN: 1521-1878
Titre abrégé: Bioessays
Pays: United States
ID NLM: 8510851
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
revised:
11
08
2023
received:
06
06
2023
accepted:
16
08
2023
medline:
27
11
2023
pubmed:
5
9
2023
entrez:
5
9
2023
Statut:
ppublish
Résumé
Although the type-I interferon (IFN-I) response is considered vertebrate-specific, recent findings about the Intracellular Pathogen Response (IPR) in nematode Caenorhabditis elegans indicate that there are similarities between these two transcriptional immunological programs. The IPR is induced during infection with natural intracellular fungal and viral pathogens of the intestine and promotes resistance against these pathogens. Similarly, the IFN-I response is induced by viruses and other intracellular pathogens and promotes resistance against infection. Whether the IPR and the IFN-I response evolved in a divergent or convergent manner is an unanswered and exciting question, which could be addressed by further studies of immunity against intracellular pathogens in C. elegans and other simple host organisms. Here we highlight similar roles played by RIG-I-like receptors, purine metabolism enzymes, proteotoxic stressors, and transcription factors to induce the IPR and IFN-I response, as well as the similar consequences of these defense programs on organismal development.
Identifiants
pubmed: 37667453
doi: 10.1002/bies.202300097
pmc: PMC10694843
doi:
Substances chimiques
Caenorhabditis elegans Proteins
0
Interferon Type I
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2300097Subventions
Organisme : NIGMS NIH HHS
ID : GM114139
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI176639
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM114139
Pays : United States
Organisme : NIA NIH HHS
ID : AG052622
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG052622
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG052622
Pays : United States
Informations de copyright
© 2023 The Authors. BioEssays published by Wiley Periodicals LLC.
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