Mimicking superinfection exclusion disrupts alphavirus infection and transmission in the yellow fever mosquito
alphaviruses
arbovirus transmission
nsP2 protease
superinfection exclusion
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
12 09 2023
12 09 2023
Historique:
medline:
7
9
2023
pubmed:
5
9
2023
entrez:
5
9
2023
Statut:
ppublish
Résumé
Multiple viruses, including pathogenic viruses, bacteriophages, and even plant viruses, cause a phenomenon termed superinfection exclusion whereby a currently infected cell is resistant to secondary infection by the same or a closely related virus. In alphaviruses, this process is thought to be mediated, at least in part, by the viral protease (nsP2) which is responsible for processing the nonstructural polyproteins (P123 and P1234) into individual proteins (nsP1-nsP4), forming the viral replication complex. Taking a synthetic biology approach, we mimicked this naturally occurring phenomenon by generating a superinfection exclusion-like state in
Identifiants
pubmed: 37669371
doi: 10.1073/pnas.2303080120
pmc: PMC10500260
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2303080120Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/I/00007033
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/I/00007038
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/I/00007039
Pays : United Kingdom
Références
J Virol. 1994 Mar;68(3):1874-85
pubmed: 8107248
J Virol. 2012 May;86(10):5554-61
pubmed: 22398285
EMBO J. 1994 Jun 15;13(12):2925-34
pubmed: 7517863
PLoS One. 2007 Nov 14;2(11):e1168
pubmed: 18000540
Insect Mol Biol. 2010 Aug;19(4):441-9
pubmed: 20456509
J Virol. 1985 May;54(2):351-7
pubmed: 3989908
Parasit Vectors. 2012 Nov 15;5:264
pubmed: 23153178
Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14622-7
pubmed: 22908261
Cell Syst. 2021 Mar 17;12(3):210-219.e3
pubmed: 33515490
J Virol. 1973 Apr;11(4):592-5
pubmed: 4735592
Viruses. 2022 Jun 17;14(6):
pubmed: 35746799
PLoS One. 2015 Apr 01;10(4):e0121097
pubmed: 25830287
Virology. 1992 Dec;191(2):932-40
pubmed: 1448929
J Virol. 2018 Nov 12;92(23):
pubmed: 30232189
Microbiol Rev. 1994 Sep;58(3):491-562
pubmed: 7968923
J Virol. 2014 Jun;88(11):6294-306
pubmed: 24672026
J Gen Virol. 2008 Mar;89(Pt 3):676-686
pubmed: 18272758
J Virol. 2018 Jun 29;92(14):
pubmed: 29695431
J Virol. 1988 Jun;62(6):2124-33
pubmed: 2835514
J Virol. 2006 Jun;80(12):5686-96
pubmed: 16731907
J Biol Chem. 2014 Feb 28;289(9):5635-53
pubmed: 24407286
Insect Mol Biol. 2012 Aug;21(4):414-21
pubmed: 22621377
J Virol. 1997 Sep;71(9):7119-23
pubmed: 9261447
Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):8967-71
pubmed: 1924357
Commun Biol. 2021 Jun 11;4(1):723
pubmed: 34117363
J Virol. 1979 Apr;30(1):45-55
pubmed: 480461
Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4550-4
pubmed: 20176967
J Virol. 2012 Jan;86(1):553-65
pubmed: 22031949
J Gen Virol. 2000 Feb;81(Pt 2):471-9
pubmed: 10644846
J Virol. 1990 May;64(5):1888-96
pubmed: 2139138
J Neurovirol. 2007 Aug;13(4):353-63
pubmed: 17849319
Curr Biol. 2005 Apr 26;15(8):714-23
pubmed: 15854903
PLoS Pathog. 2020 Jan 16;16(1):e1008103
pubmed: 31945137
Viruses. 2020 Nov 05;12(11):
pubmed: 33167513
J Virol. 2019 Aug 28;93(18):
pubmed: 31217251
PLoS One. 2020 Nov 12;15(11):e0241592
pubmed: 33180795
J Gen Virol. 2018 Jun;99(6):761-762
pubmed: 29745869
J Gen Virol. 2020 Jan;101(1):96-104
pubmed: 31674898
PLoS Pathog. 2020 Sep 4;16(9):e1008825
pubmed: 32886709
J Virol. 2003 Apr;77(7):4283-90
pubmed: 12634385
J Bacteriol. 1995 Jun;177(11):3080-6
pubmed: 7768804
PLoS Negl Trop Dis. 2019 Sep 3;13(9):e0007579
pubmed: 31479450
Virology. 1995 Sep 10;212(1):1-12
pubmed: 7676618
Virology. 1992 Aug;189(2):462-73
pubmed: 1386484
J Virol. 2013 Dec;87(24):13354-69
pubmed: 24089557
J Gen Virol. 2017 Jan;98(1):43-49
pubmed: 28206905
J Virol. 2006 Jan;80(1):360-71
pubmed: 16352561
Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):11984-9
pubmed: 11050229
Commun Biol. 2018 Feb 8;1:11
pubmed: 30271898
Sci Rep. 2021 Dec 13;11(1):23865
pubmed: 34903766
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4198-203
pubmed: 16537508
J Virol. 1989 Nov;63(11):4653-64
pubmed: 2529379
J Virol. 1988 Jan;62(1):346-8
pubmed: 2824854
Viruses. 2014 Dec 22;6(12):5182-97
pubmed: 25533661