Lu-177-Labeled Hetero-Bivalent Agents Targeting PSMA and Bone Metastases for Radionuclide Therapy.

Male Humans Animals Mice Radioisotopes / therapeutic use Lutetium / therapeutic use Gallium Radioisotopes Tissue Distribution Bone Neoplasms / diagnostic imaging Prostatic Neoplasms / diagnostic imaging

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
14 09 2023
Historique:
medline: 15 9 2023
pubmed: 6 9 2023
entrez: 5 9 2023
Statut: ppublish

Résumé

Prostate-specific membrane antigen (PSMA) is an excellent target for imaging and radionuclide therapy of prostate cancer. Recently, [

Identifiants

DOI: 10.1021/acs.jmedchem.3c01294 PMID: 37670407
pubmed: 37670407
doi: 10.1021/acs.jmedchem.3c01294
doi:

Substances chimiques

Lutetium-177 BRH40Y9V1Q
Radioisotopes 0
Lutetium 5H0DOZ21UJ
Gallium Radioisotopes 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

12602-12613

Auteurs

Zhihao Zha (Z)

Five Eleven Pharma Inc., Philadelphia, Pennsylvania 19104, United States.

Karl Ploessl (K)

Five Eleven Pharma Inc., Philadelphia, Pennsylvania 19104, United States.
ORCID: 0000-0001-7896-5900

Seok Rye Choi (SR)

Five Eleven Pharma Inc., Philadelphia, Pennsylvania 19104, United States.

Ruiyue Zhao (R)

College of Chemistry, Beijing Normal University, Beijing 100875, P. R. China.

Wenbin Jin (W)

College of Chemistry, Beijing Normal University, Beijing 100875, P. R. China.

Ran Wang (R)

College of Chemistry, Beijing Normal University, Beijing 100875, P. R. China.

David Alexoff (D)

Five Eleven Pharma Inc., Philadelphia, Pennsylvania 19104, United States.

Lin Zhu (L)

College of Chemistry, Beijing Normal University, Beijing 100875, P. R. China.

Hank F Kung (HF)

Five Eleven Pharma Inc., Philadelphia, Pennsylvania 19104, United States.
Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
ORCID: 0000-0003-3254-8049

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Lu-177-Labeled Hetero-Bivalent Agents...
questionsmedicales.fr › Eucaryotes › Animaux › Lu-177-Labeled Hetero-Bivalent Agents...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lu-177-Labeled Hetero-Bivalent Agents...
questionsmedicales.fr › Produits chimiques inorganiques › Isotopes › Radio-isotopes › Lu-177-Labeled Hetero-Bivalent Agents...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Terres rares › Lanthanides › Lutétium › Lu-177-Labeled Hetero-Bivalent Agents...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Gallium › Isotopes du gallium › Radio-isotopes du gallium › Lu-177-Labeled Hetero-Bivalent Agents...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Distribution tissulaire › Lu-177-Labeled Hetero-Bivalent Agents...
questionsmedicales.fr › Maladies ostéomusculaires › Maladies osseuses › Tumeurs osseuses › Lu-177-Labeled Hetero-Bivalent Agents...
questionsmedicales.fr › Maladies urogénitales › Tumeurs de l'appareil urogénital › Tumeurs de l'appareil génital mâle › Tumeurs de la prostate › Lu-177-Labeled Hetero-Bivalent Agents...