Functional alterations in resting-state networks for Theory of Mind in Parkinson's disease.
Parkinson's disease
Theory of Mind
functional connectivity
resting state
Journal
The European journal of neuroscience
ISSN: 1460-9568
Titre abrégé: Eur J Neurosci
Pays: France
ID NLM: 8918110
Informations de publication
Date de publication:
Mar 2024
Mar 2024
Historique:
revised:
23
08
2023
received:
31
05
2023
accepted:
26
08
2023
pubmed:
6
9
2023
medline:
6
9
2023
entrez:
6
9
2023
Statut:
ppublish
Résumé
In Parkinson's disease (PD), impairment of Theory of Mind (ToM) has recently attracted an increasing number of neuroscientific investigations. If and how functional connectivity of the ToM network is altered in PD is still an open question. First, we explored whether ToM network connectivity shows potential PD-specific functional alterations when compared to healthy controls (HC). Second, we tested the role of the duration of PD in the evolution of functional alterations in the ToM network. Between-group connectivity alterations were computed adopting resting-state functional magnetic resonance imaging (rs-fMRI) data of four groups: PD patients with short disease duration (PD-1, n = 72); PD patients with long disease duration (PD-2, n = 22); healthy controls for PD-1 (HC-1, n = 69); healthy controls for PD-2 (HC-2, n = 22). We explored connectivity differences in the ToM network within and between its three subnetworks: Affective, Cognitive and Core. PD-1 presented a global pattern of decreased functional connectivity within the ToM network, compared to HC-1. The alterations mainly involved the Cognitive and Affective ToM subnetworks and their reciprocal connections. PD-2-those with longer disease duration-showed an increased connectivity spanning the entire ToM network, albeit less consistently in the Core ToM network, compared to both the PD-1 and the HC-2 groups. Functional connectivity within the ToM network is altered in PD. The alterations follow a graded pattern, with decreased connectivity at short disease duration, which broadens to a generalized increase with longer disease duration. The alterations involve both the Cognitive and Affective subnetworks of ToM.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1213-1226Subventions
Organisme : NIA NIH HHS
Pays : United States
Organisme : NIBIB NIH HHS
Pays : United States
Organisme : NIA NIH HHS
Pays : United States
Organisme : NIBIB NIH HHS
Pays : United States
Informations de copyright
© 2023 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
Références
Aarsland, D., Andersen, K., Larsen, J. P., Lolk, A., Nielsen, H., & Kragh‐Sørensen, P. (2001). Risk of dementia in Parkinson's disease: A community‐based, prospective study. Neurology, 56(6), 730–736. https://doi.org/10.1212/WNL.56.6.730
Abu‐Akel, A., & Shamay‐Tsoory, S. (2011). Neuroanatomical and neurochemical bases of theory of mind. Neuropsychologia, 49(11), 2971–2984. https://doi.org/10.1016/J.NEUROPSYCHOLOGIA.2011.07.012
Alonso‐Recio, L., Carvajal, F., Merino, C., & Serrano, J. M. (2021). Social cognition and cognitive decline in patients with Parkinson's disease. Journal of the International Neuropsychological Society, 27(7), 744–755. https://doi.org/10.1017/S1355617720001204
Alves, P. N., Foulon, C., Karolis, V., Bzdok, D., Margulies, D. S., Volle, E., & Thiebaut de Schotten, M. (2019). An improved neuroanatomical model of the default‐mode network reconciles previous neuroimaging and neuropathological findings. Communications Biology, 2(1), 1–14. https://doi.org/10.1038/s42003-019-0611-3
Barone, P., Aarsland, D., Burn, D., Emre, M., Kulisevsky, J., & Weintraub, D. (2011). Cognitive impairment in nondemented Parkinson's disease. Movement Disorders, 26(14), 2483–2495. https://doi.org/10.1002/MDS.23919
Baudrexel, S., Witte, T., Seifried, C., von Wegner, F., Beissner, F., Klein, J. C., Steinmetz, H., Deichmann, R., Roeper, J., & Hilker, R. (2011). Resting state fMRI reveals increased subthalamic nucleus‐motor cortex connectivity in Parkinson's disease. NeuroImage, 55(4), 1728–1738. https://doi.org/10.1016/J.NEUROIMAGE.2011.01.017
Bellucci, A., Mercuri, N. B., Venneri, A., Faustini, G., Longhena, F., Pizzi, M., Missale, C., & Spano, P. F. (2016). Review: Parkinson's disease: From synaptic loss to connectome dysfunction. Neuropathology and Applied Neurobiology, 42(1), 77–94. https://doi.org/10.1111/NAN.12297
Bodden, M. E., Mollenhauer, B., Trenkwalder, C., Cabanel, N., Eggert, K. M., Unger, M. M., Oertel, W. H., Kessler, J., Dodel, R., & Kalbe, E. (2010). Affective and cognitive theory of mind in patients with Parkinson's disease. Parkinsonism & Related Disorders, 16(7), 466–470. https://doi.org/10.1016/J.PARKRELDIS.2010.04.014
Bodden, M. E., Dodel, R., & Kalbe, E. (2010). Theory of mind in Parkinson's disease and related basal ganglia disorders: A systematic review. Movement Disorders, 25(1), 13–27. https://doi.org/10.1002/MDS.22818
Bora, E., Walterfang, M., & Velakoulis, D. (2015). Theory of mind in Parkinson's disease: A meta‐analysis. Behavioural Brain Research, 292, 515–520. https://doi.org/10.1016/J.BBR.2015.07.012
Buckner, R. L., & DiNicola, L. M. (2019). The brain's default network: Updated anatomy, physiology and evolving insights. Nature Reviews Neuroscience, 20, 593–608. https://doi.org/10.1038/s41583-019-0212-7
Campanella, F., West, T., Corradi‐Dell'acqua, C., & Skrap, M. (2022). Cognitive and affective theory of mind double dissociation after parietal and temporal lobe tumours. Brain, 145(5), 1818–1829. https://doi.org/10.1093/BRAIN/AWAB441
Caspers, J., Rubbert, C., Eickhoff, S. B., Hoffstaedter, F., Südmeyer, M., Hartmann, C. J., Sigl, B., Teichert, N., Aissa, J., Turowski, B., Schnitzler, A., & Mathys, C. (2021). Within‐ and across‐network alterations of the sensorimotor network in Parkinson's disease. Neuroradiology, 63(12), 2073–2085. https://doi.org/10.1007/S00234-021-02731-W/FIGURES/5
Cerasa, A., Novellino, F., & Quattrone, A. (2016). Connectivity changes in Parkinson's disease. Current Neurology and Neuroscience Reports, 16(10), 1–11. https://doi.org/10.1007/S11910-016-0687-9/TABLES/4
Christidi, F., Migliaccio, R., Santamaría‐García, H., Santangelo, G., & Trojsi, F. (2018). Social cognition dysfunctions in neurodegenerative diseases: Neuroanatomical correlates and clinical implications. Behavioural Neurology, 2018, 1849794. https://doi.org/10.1155/2018/1849794
Corradi‐Dell'Acqua, C., Ronchi, R., Thomasson, M., Bernati, T., Saj, A., & Vuilleumier, P. (2020). Deficits in cognitive and affective theory of mind relate to dissociated lesion patterns in prefrontal and insular cortex. Cortex, 128, 218–233. https://doi.org/10.1016/J.CORTEX.2020.03.019
Coundouris, S. P., Adams, A. G., & Henry, J. D. (2020). Empathy and theory of mind in Parkinson's disease: A meta‐analysis. Neuroscience & Biobehavioral Reviews, 109, 92–102. https://doi.org/10.1016/J.NEUBIOREV.2019.12.030
Díez‐Cirarda, M., Ojeda, N., Peña, J., Cabrera‐Zubizarreta, A., Gómez‐Beldarrain, M. Á., Gómez‐Esteban, J. C., & Ibarretxe‐Bilbao, N. (2015). Neuroanatomical correlates of theory of mind deficit in Parkinson's disease: A multimodal imaging study. PLoS ONE, 10(11), e0142234. https://doi.org/10.1371/JOURNAL.PONE.0142234
Dodich, A., Funghi, G., Meli, C., Pennacchio, M., Longo, C., Malaguti, M. C., di Giacopo, R., Zappini, F., Turella, L., & Papagno, C. (2022). Deficits in emotion recognition and theory of mind in Parkinson's disease patients with and without cognitive impairments. Frontiers in Psychology, 13, 866809. https://doi.org/10.3389/FPSYG.2022.866809
Fan, L., Li, H., Zhuo, J., Zhang, Y., Wang, J., Chen, L., Yang, Z., Chu, C., Xie, S., Laird, A. R., Fox, P. T., Eickhoff, S. B., Yu, C., & Jiang, T. (2016). The human Brainnetome atlas: A new brain atlas based on connectional architecture. Cerebral Cortex, 26(8), 3508–3526. https://doi.org/10.1093/CERCOR/BHW157
Filippi, M., Basaia, S., Sarasso, E., Stojkovic, T., Stankovic, I., Fontana, A., Tomic, A., Piramide, N., Stefanova, E., Markovic, V., Kostic, V. S., & Agosta, F. (2021). Longitudinal brain connectivity changes and clinical evolution in Parkinson's disease. Molecular Psychiatry, 26(9), 5429–5440. https://doi.org/10.1038/s41380-020-0770-0
Fiorenzato, E., Strafella, A. P., Kim, J., Schifano, R., Weis, L., Antonini, A., & Biundo, R. (2019). Dynamic functional connectivity changes associated with dementia in Parkinson's disease. Brain, 142(9), 2860–2872. https://doi.org/10.1093/BRAIN/AWZ192
Foley, J. A., Lancaster, C., Poznyak, E., Borejko, O., Niven, E., Foltynie, T., & Cipolotti, L. (2019). Impairment in theory of mind in Parkinson's disease is explained by deficits in inhibition. Parkinson's Disease, 2019, 1–8. https://doi.org/10.1155/2019/5480913
Hassan, M., Chaton, L., Benquet, P., Delval, A., Leroy, C., Plomhause, L., Moonen, A. J. H., Duits, A. A., Leentjens, A. F. G., van Kranen‐Mastenbroek, V., Defebvre, L., Derambure, P., Wendling, F., & Dujardin, K. (2017). Functional connectivity disruptions correlate with cognitive phenotypes in Parkinson's disease. NeuroImage: Clinical, 14, 591–601. https://doi.org/10.1016/J.NICL.2017.03.002
Herz, D. M., Haagensen, B. N., Nielsen, S. H., Madsen, K. H., Løkkegaard, A., & Siebner, H. R. (2016). Resting‐state connectivity predicts levodopa‐induced dyskinesias in Parkinson's disease. Movement Disorders, 31(4), 521–529. https://doi.org/10.1002/MDS.26540
Jankovic, J. (2008). Parkinson's disease: Clinical features and diagnosis. Journal of Neurology, Neurosurgery & Psychiatry, 79(4), 368–376. https://doi.org/10.1136/JNNP.2007.131045
Kalbe, E., Schlegel, M., Sack, A. T., Nowak, D. A., Dafotakis, M., Bangard, C., Brand, M., Shamay‐Tsoory, S., Onur, O. A., & Kessler, J. (2010). Dissociating cognitive from affective theory of mind: A TMS study. Cortex, 46(6), 769–780. https://doi.org/10.1016/J.CORTEX.2009.07.010
Kehagia, A. A., Barker, R. A., & Robbins, T. W. (2010). Neuropsychological and clinical heterogeneity of cognitive impairment and dementia in patients with Parkinson's disease. The Lancet Neurology, 9(12), 1200–1213. https://doi.org/10.1016/S1474-4422(10)70212-X
Kelly, C., de Zubicaray, G., di Martino, A., Copland, D. A., Reiss, P. T., Klein, D. F., Castellanos, F. X., Milham, M. P., & McMahon, K. (2009). L‐Dopa modulates functional connectivity in striatal cognitive and motor networks: A double‐blind placebo‐controlled study. Journal of Neuroscience, 29(22), 7364–7378. https://doi.org/10.1523/JNEUROSCI.0810-09.2009
Krajcovicova, L., Mikl, M., Marecek, R., & Rektorova, I. (2012). The default mode network integrity in patients with Parkinson's disease is levodopa equivalent dose‐dependent. Journal of Neural Transmission, 119(4), 443–454. https://doi.org/10.1007/S00702-011-0723-5/FIGURES/4
Lucas‐Jiménez, O., Ojeda, N., Peña, J., Díez‐Cirarda, M., Cabrera‐Zubizarreta, A., Gómez‐Esteban, J. C., Gómez‐Beldarrain, M. Á., & Ibarretxe‐Bilbao, N. (2016). Altered functional connectivity in the default mode network is associated with cognitive impairment and brain anatomical changes in Parkinson's disease. Parkinsonism & Related Disorders, 33, 58–64. https://doi.org/10.1016/J.PARKRELDIS.2016.09.012
MacDonald, P. A., & Monchi, O. (2011). Differential effects of dopaminergic therapies on dorsal and ventral striatum in Parkinson's disease: Implications for cognitive function. Parkinson's Disease., 2011, 1–18. https://doi.org/10.4061/2011/572743
Maggi, G., Muñoz, A. M. C., Obeso, I., & Santangelo, G. (2022). Neuropsychological, neuropsychiatric, and clinical correlates of affective and cognitive theory of mind in Parkinson's disease: A meta‐analysis. Neuropsychology, 36(6), 483–504. https://doi.org/10.1037/NEU0000807
Marek, K., Jennings, D., Lasch, S., Siderowf, A., Tanner, C., Simuni, T., Coffey, C., Kieburtz, K., Flagg, E., Chowdhury, S., Poewe, W., Mollenhauer, B., Klinik, P. E., Sherer, T., Frasier, M., Meunier, C., Rudolph, A., Casaceli, C., Seibyl, J., … Taylor, P. (2011). The Parkinson progression marker initiative (PPMI). Progress in Neurobiology, 95(4), 629–635. https://doi.org/10.1016/J.PNEUROBIO.2011.09.005
Mars, R. B., Neubert, F. X., Noonan, M. A. P., Sallet, J., Toni, I., & Rushworth, M. F. S. (2012). On the relationship between the “default mode network” and the “social brain.”. Frontiers in Human Neuroscience, 6, 1–9. https://doi.org/10.3389/FNHUM.2012.00189/BIBTEX
Martinez‐Horta, S., & Kulisevsky, J. (2019). Mild cognitive impairment in Parkinson's disease. Journal of Neural Transmission, 126, 897–904. https://doi.org/10.1007/s00702-019-02003-1
Mattavelli, G., Barvas, E., Longo, C., Zappini, F., Ottaviani, D., Malaguti, M. C., Pellegrini, M., & Papagno, C. (2021). Facial expressions recognition and discrimination in Parkinson's disease. Journal of Neuropsychology, 15(1), 46–68. https://doi.org/10.1111/JNP.12209
Muslimović, D., Post, B., Speelman, J. D., & Schmand, B. (2005). Cognitive profile of patients with newly diagnosed Parkinson disease. Neurology, 65(8), 1239–1245. https://doi.org/10.1212/01.WNL.0000180516.69442.95
Narme, P., Mouras, H., Roussel, M., Duru, C., Krystkowiak, P., & Godefroy, O. (2013). Emotional and cognitive social processes are impaired in Parkinson's disease and are related to behavioral disorders. Neuropsychology, 27(2), 182–192. https://doi.org/10.1037/A0031522
Nigro, S., Riccelli, R., Passamonti, L., Arabia, G., Morelli, M., Nisticò, R., Novellino, F., Salsone, M., Barbagallo, G., & Quattrone, A. (2016). Characterizing structural neural networks in de novo Parkinson disease patients using diffusion tensor imaging. Human Brain Mapping, 37(12), 4500–4510. https://doi.org/10.1002/HBM.23324
Obeso, J. A., Stamelou, M., Goetz, C. G., Poewe, W., Lang, A. E., Weintraub, D., Burn, D., Halliday, G. M., Bezard, E., Przedborski, S., Lehericy, S., Brooks, D. J., Rothwell, J. C., Hallett, M., DeLong, M. R., Marras, C., Tanner, C. M., Ross, G. W., Langston, J. W., … Stoessl, A. J. (2017). Past, present, and future of Parkinson's disease: A special essay on the 200th anniversary of the shaking palsy. Movement Disorders, 32(9), 1264–1310. https://doi.org/10.1002/MDS.27115
Obeso, J. A., Rodríguez‐Oroz, M. C., Benitez‐Temino, B., Blesa, F. J., Guridi, J., Marin, C., & Rodriguez, M. (2008). Functional organization of the basal ganglia: Therapeutic implications for Parkinson's disease. Movement Disorders, 23(S3), S548–S559. https://doi.org/10.1002/MDS.22062
Orso, B., Arnaldi, D., Famà, F., Girtler, N., Brugnolo, A., Doglione, E., Filippi, L., Massa, F., Peira, E., Bauckneht, M., Morbelli, S., Nobili, F., & Pardini, M. (2020). Anatomical and neurochemical bases of theory of mind in de novo Parkinson's disease. Cortex; a Journal Devoted to the Study of the Nervous System and Behavior, 130, 401–412. https://doi.org/10.1016/J.CORTEX.2020.06.012
Papagno, C., & Trojano, L. (2018). Cognitive and behavioral disorders in Parkinson's disease: An update. I: Cognitive impairments. Neurological Sciences, 39(2), 215–223. https://doi.org/10.1007/S10072-017-3154-8/TABLES/1
Perez, F., Helmer, C., Foubert‐Samier, A., Auriacombe, S., Dartigues, J. F., & Tison, F. (2012). Risk of dementia in an elderly population of Parkinson's disease patients: A 15‐year population‐based study. Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 8(6), 463–469. https://doi.org/10.1016/J.JALZ.2011.09.230
Péron, J., le Jeune, F., Haegelen, C., Dondaine, T., Drapier, D., Sauleau, P., Reymann, J. M., Drapier, S., Rouaud, T., Millet, B., & Vérin, M. (2010). Subthalamic nucleus stimulation affects theory of mind network: A PET study in Parkinson's disease. PLoS ONE, 5(3), e9919. https://doi.org/10.1371/JOURNAL.PONE.0009919
Petersen, R. C., Caracciolo, B., Brayne, C., Gauthier, S., Jelic, V., & Fratiglioni, L. (2014). Mild cognitive impairment: A concept in evolution. Journal of Internal Medicine, 275(3), 214–228. https://doi.org/10.1111/JOIM.12190
Premack, D., & Woodruff, G. (1978). Does the chimpanzee have a theory of mind? Behavioral and Brain Sciences, 1(4), 515–526. https://doi.org/10.1017/S0140525X00076512
Raichle, M. E. (2015). The brain's default mode network. Annual Review of Neuroscience, 38, 433–447. https://doi.org/10.1146/ANNUREV-NEURO-071013-014030
Romosan, A. M., Dehelean, L., Romosan, R. S., Andor, M., Bredicean, A. C., & Simu, M. A. (2019). Affective theory of mind in Parkinson's disease: The effect of cognitive performance. Neuropsychiatric Disease and Treatment, 15, 2521–2535. https://doi.org/10.2147/NDT.S219288
Rossetto, F., Castelli, I., Baglio, F., Massaro, D., Alberoni, M., Nemni, R., Shamay‐Tsoory, S., & Marchetti, A. (2018). Cognitive and affective theory of mind in mild cognitive impairment and Parkinson's disease: Preliminary evidence from the Italian version of the Yoni task. Developmental Neuropsychology, 43(8), 764–780. https://doi.org/10.1080/87565641.2018.1529175
Santangelo, G., Vitale, C., Trojano, L., Errico, D., Amboni, M., Barbarulo, A. M., Grossi, D., & Barone, P. (2012). Neuropsychological correlates of theory of mind in patients with early Parkinson's disease. Movement Disorders: Official Journal of the Movement Disorder Society, 27(1), 98–105. https://doi.org/10.1002/MDS.23949
Shamay‐Tsoory, S. G., Tomer, R., Berger, B. D., Goldsher, D., & Aharon‐Peretz, J. (2005). Impaired “affective theory of mind” is associated with right ventromedial prefrontal damage. Cognitive and Behavioral Neurology, 18(1), 55–67. https://doi.org/10.1097/01.WNN.0000152228.90129.99
Shamay‐Tsoory, S. G., & Aharon‐Peretz, J. (2007). Dissociable prefrontal networks for cognitive and affective theory of mind: A lesion study. Neuropsychologia, 45(13), 3054–3067. https://doi.org/10.1016/J.NEUROPSYCHOLOGIA.2007.05.021
Smallwood, J., Bernhardt, B. C., Leech, R., Bzdok, D., Jefferies, E., & Margulies, D. S. (2021). The default mode network in cognition: A topographical perspective. Nature Reviews Neuroscience, 22(8), 503–513. https://doi.org/10.1038/s41583-021-00474-4
Smith, D. V., Utevsky, A. V., Bland, A. R., Clement, N., Clithero, J. A., Harsch, A. E. W., McKell Carter, R., & Huettel, S. A. (2014). Characterizing individual differences in functional connectivity using dual‐regression and seed‐based approaches. NeuroImage, 95, 1–12. https://doi.org/10.1016/J.NEUROIMAGE.2014.03.042
Strikwerda‐Brown, C., Ramanan, S., & Irish, M. (2019). Neurocognitive mechanisms of theory of mind impairment in neurodegeneration: A transdiagnostic approach. Neuropsychiatric Disease and Treatment, 15, 557–573. https://doi.org/10.2147/NDT.S158996
Tessitore, A., Amboni, M., Esposito, F., Russo, A., Picillo, M., Marcuccio, L., Pellecchia, M. T., Vitale, C., Cirillo, M., Tedeschi, G., & Barone, P. (2012). Resting‐state brain connectivity in patients with Parkinson's disease and freezing of gait. Parkinsonism & Related Disorders, 18(6), 781–787. https://doi.org/10.1016/J.PARKRELDIS.2012.03.018
Tessitore, A., Cirillo, M., & De Micco, R. (2019). Functional connectivity signatures of Parkinson's disease. Journal of Parkinson's Disease, 9(4), 637–652. https://doi.org/10.3233/JPD-191592
Tessitore, A., Giordano, A., de Micco, R., Russo, A., & Tedeschi, G. (2014). Sensorimotor connectivity in Parkinson's disease: The role of functional neuroimaging. Frontiers in Neurology, 5, 180. https://doi.org/10.3389/FNEUR.2014.00180/BIBTEX
Trojano, L., & Papagno, C. (2018). Cognitive and behavioral disorders in Parkinson's disease: An update. II: Behavioral disorders. Neurological Sciences, 39(1), 53–61. https://doi.org/10.1007/S10072-017-3155-7/TABLES/1
Trompeta, C., Fernández Rodríguez, B., & Gasca‐Salas, C. (2021). What do we know about theory of mind impairment in Parkinson's disease? Behavioral Sciences, 11(10), 130. https://doi.org/10.3390/BS11100130
Tuovinen, N., Seppi, K., de Pasquale, F., Müller, C., Nocker, M., Schocke, M., Gizewski, E. R., Kremser, C., Wenning, G. K., Poewe, W., Djamshidian, A., Scherfler, C., & Seki, M. (2018). The reorganization of functional architecture in the early‐stages of Parkinson's disease. Parkinsonism & Related Disorders, 50, 61–68. https://doi.org/10.1016/J.PARKRELDIS.2018.02.013
Weis, S., Patil, K. R., Hoffstaedter, F., Nostro, A., Yeo, B. T. T., & Eickhoff, S. B. (2020). Sex classification by resting state brain connectivity. Cerebral Cortex, 30(2), 824–835. https://doi.org/10.1093/CERCOR/BHZ129
Whitfield‐Gabrieli, S., & Nieto‐Castanon, A. (2012). Conn: A functional connectivity toolbox for correlated and anticorrelated brain networks. Brain Connectivity, 2(3), 125–141.
Yang, W., Liu, B., Huang, B., Huang, R., Wang, L., Zhang, Y., Zhang, X., & Wu, K. (2016). Altered resting‐state functional connectivity of the striatum in Parkinson's disease after levodopa administration. PLoS ONE, 11(9), e0161935. https://doi.org/10.1371/JOURNAL.PONE.0161935
Yeshurun, Y., Nguyen, M., & Hasson, U. (2021). The default mode network: Where the idiosyncratic self meets the shared social world. Nature Reviews Neuroscience, 22(3), 181–192. https://doi.org/10.1038/s41583-020-00420-w
Yoshimura, N., Kawamura, M., Masaoka, Y., & Homma, I. (2005). The amygdala of patients with Parkinson's disease is silent in response to fearful facial expressions. Neuroscience, 131(2), 523–534. https://doi.org/10.1016/J.NEUROSCIENCE.2004.09.054
Yu, R. L., Wu, R. M., Chiu, M. J., Tai, C. H., Lin, C. H., & Hua, M. S. (2012). Advanced theory of mind in patients at early stage of Parkinson's disease. Parkinsonism & Related Disorders, 18(1), 21–24. https://doi.org/10.1016/J.PARKRELDIS.2011.08.003
Zhong, J., Guan, X., Zhong, X., Cao, F., Gu, Q., Guo, T., Zhou, C., Zeng, Q., Wang, J., Gao, T., & Zhang, M. (2019). Levodopa imparts a normalizing effect on default‐mode network connectivity in non‐demented Parkinson's disease. Neuroscience Letters, 705, 159–166. https://doi.org/10.1016/J.NEULET.2019.04.042