General anesthesia alters CNS and astrocyte expression of activity-dependent and activity-independent genes.
astrocytes
general anesthesia
neurodegenerating diseases
synaptic activity
transcriptional regulation
Journal
Frontiers in network physiology
ISSN: 2674-0109
Titre abrégé: Front Netw Physiol
Pays: Switzerland
ID NLM: 9918334487406676
Informations de publication
Date de publication:
2023
2023
Historique:
received:
03
05
2023
accepted:
21
07
2023
medline:
6
9
2023
pubmed:
6
9
2023
entrez:
6
9
2023
Statut:
epublish
Résumé
General anesthesia represents a common clinical intervention and yet can result in long-term adverse CNS effects particularly in the elderly or dementia patients. Suppression of cortical activity is a key feature of the anesthetic-induced unconscious state, with activity being a well-described regulator of pathways important for brain health. However, the extent to which the effects of anesthesia go beyond simple suppression of neuronal activity is incompletely understood. We found that general anesthesia lowered cortical expression of genes induced by physiological activity
Identifiants
pubmed: 37670849
doi: 10.3389/fnetp.2023.1216366
pii: 1216366
pmc: PMC10476527
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1216366Subventions
Organisme : Chief Scientist Office
ID : PCL/20/05
Pays : United Kingdom
Informations de copyright
Copyright © 2023 Jiwaji, Márkus, McQueen, Emelianova, He, Dando, Chandran and Hardingham.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Cell Rep. 2022 Oct 18;41(3):111474
pubmed: 36261025
Nat Commun. 2015 Apr 09;6:6761
pubmed: 25854456
Nature. 2017 Jan 26;541(7638):481-487
pubmed: 28099414
Neuron. 2016 Jul 6;91(1):119-32
pubmed: 27292539
Ann Neurol. 2012 May;71(5):687-98
pubmed: 22368036
Anaesthesia. 2018 May;73(5):549-555
pubmed: 29468634
Exp Mol Med. 2018 Apr 9;50(4):1-7
pubmed: 29628504
Nat Neurosci. 2008 Apr;11(4):476-87
pubmed: 18344994
Proc Natl Acad Sci U S A. 2014 May 6;111(18):E1818-20
pubmed: 24753562
Nature. 2008 Oct 30;455(7217):1198-204
pubmed: 18815592
Brain Res. 2011 Mar 24;1381:124-33
pubmed: 21241667
Nat Protoc. 2014;9(6):1282-91
pubmed: 24810037
Proc Natl Acad Sci U S A. 2020 Jun 16;117(24):13757-13766
pubmed: 32467161
Korean J Anesthesiol. 2010 Jul;59(1):3-8
pubmed: 20651990
Sci Rep. 2020 Jun 9;10(1):9366
pubmed: 32518252
J Neurosci. 2010 Feb 17;30(7):2623-35
pubmed: 20164347
Glia. 2000 Oct;32(1):1-14
pubmed: 10975906
Nat Commun. 2017 May 02;8:15132
pubmed: 28462931
Nature. 2023 Feb;614(7949):732-741
pubmed: 36792830
Cell. 2008 Nov 14;135(4):749-62
pubmed: 19013282
Lancet. 2008 Jul 12;372(9633):139-144
pubmed: 18582931
Int J Mol Sci. 2020 Mar 12;21(6):
pubmed: 32178355
Nat Commun. 2022 Jan 10;13(1):135
pubmed: 35013236
Neurosci Biobehav Rev. 2016 Dec;71:484-505
pubmed: 27693230
Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18974-9
pubmed: 23112168
J Neurosci. 2017 May 24;37(21):5263-5273
pubmed: 28539349
J Neurosci. 2012 May 2;32(18):6391-410
pubmed: 22553043
Glia. 2016 Apr;64(4):524-36
pubmed: 26666873
Free Radic Biol Med. 2022 Mar;182:93-99
pubmed: 35202786
Cell Death Dis. 2021 Feb 26;12(2):218
pubmed: 33637689
Neuron. 2012 Jun 7;74(5):809-15
pubmed: 22681686
Nat Neurosci. 2018 Jan;21(1):120-129
pubmed: 29230054
Cell Rep. 2018 Jan 2;22(1):269-285
pubmed: 29298427
Nat Commun. 2016 Apr 19;7:11022
pubmed: 27090946
Cell Metab. 2011 Dec 7;14(6):724-38
pubmed: 22152301
Eur J Pharmacol. 2020 Aug 15;881:173188
pubmed: 32439258
Anesthesiology. 2004 Feb;100(2):309-14
pubmed: 14739805
Cereb Cortex. 2005 Sep;15(9):1322-31
pubmed: 15647528
Neurosci Lett. 1993 Sep 3;159(1-2):91-4
pubmed: 8264987
Nat Neurosci. 2021 Mar;24(3):312-325
pubmed: 33589835
Cell. 2019 May 30;177(6):1522-1535.e14
pubmed: 31130380
J Cereb Blood Flow Metab. 2018 Dec;38(12):2192-2208
pubmed: 30009645
J Cereb Blood Flow Metab. 2017 Nov;37(11):3556-3567
pubmed: 28350285
BMC Biol. 2015 Aug 25;13:66
pubmed: 26303010
Ann Neurol. 2008 Dec;64(6):618-27
pubmed: 19006075
J Alzheimers Dis. 2010;19(4):1245-57
pubmed: 20308791
Clin Interv Aging. 2008;3(2):351-5
pubmed: 18686756
Curr Opin Neurobiol. 2011 Apr;21(2):299-305
pubmed: 21292474
Anesthesiology. 2002 May;96(5):1223-9
pubmed: 11981164
Neuroscience. 2005;135(3):815-27
pubmed: 16154281
Cold Spring Harb Perspect Biol. 2015 Feb 13;7(12):
pubmed: 25680832
Front Aging Neurosci. 2022 Jan 11;13:802582
pubmed: 35087395