In vivo method for evaluating sunscreen protection against high-energy visible light.
Journal
Journal of the European Academy of Dermatology and Venereology : JEADV
ISSN: 1468-3083
Titre abrégé: J Eur Acad Dermatol Venereol
Pays: England
ID NLM: 9216037
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
30
01
2023
accepted:
30
05
2023
medline:
7
9
2023
pubmed:
6
9
2023
entrez:
6
9
2023
Statut:
ppublish
Résumé
Overexposure to sunlight can have many harmful biological effects on the skin, leading to skin cancer and photoaging. As ultraviolet (UV) radiation has been identified as a cause of DNA damage and oxidative stress in the skin, the photoprotection provided by sunscreens is evaluated through their ability to filter UV light, using the sun protection factor (SPF). However, recent data have shown that high-energy visible (HEV) light can also cause biological skin damage. To develop a new in vivo method for evaluating the protection provided by sunscreens across a broad range of wavelengths, including the HEV band, based on multispectral image analysis. This study evaluated the absorption properties of six commercially available sunscreens (five SPF 50+ products containing organic UV filters, and one product containing the wide spectrum filter, phenylene bis-diphenyltriazine [TriAsorB™]) and of a control product containing no filter. Multispectral images were acquired from the skin on the forearms of healthy volunteers, before and after application of the test products. Images taken with LEDs emitting light at wavelengths ranging from UV to infrared were used to generate light reflectance maps for each product. The levels of absorbance of light in the UV and visible bands were then calculated. The product containing the wide spectrum filter exhibited significantly higher absorbance over the HEV band (380-450 nm) than the control product and the other commercial sunscreens. All the sunscreens tested showed the same level of absorbance at 365 nm (UVA). Multispectral imaging provides a simple and reliable in vivo method for assessing the real-world protection provided by sunscreens against all forms of photo-induced skin damage, including that induced by HEV radiation.
Sections du résumé
BACKGROUND
BACKGROUND
Overexposure to sunlight can have many harmful biological effects on the skin, leading to skin cancer and photoaging. As ultraviolet (UV) radiation has been identified as a cause of DNA damage and oxidative stress in the skin, the photoprotection provided by sunscreens is evaluated through their ability to filter UV light, using the sun protection factor (SPF). However, recent data have shown that high-energy visible (HEV) light can also cause biological skin damage.
OBJECTIVES
OBJECTIVE
To develop a new in vivo method for evaluating the protection provided by sunscreens across a broad range of wavelengths, including the HEV band, based on multispectral image analysis.
METHODS
METHODS
This study evaluated the absorption properties of six commercially available sunscreens (five SPF 50+ products containing organic UV filters, and one product containing the wide spectrum filter, phenylene bis-diphenyltriazine [TriAsorB™]) and of a control product containing no filter. Multispectral images were acquired from the skin on the forearms of healthy volunteers, before and after application of the test products. Images taken with LEDs emitting light at wavelengths ranging from UV to infrared were used to generate light reflectance maps for each product. The levels of absorbance of light in the UV and visible bands were then calculated.
RESULTS
RESULTS
The product containing the wide spectrum filter exhibited significantly higher absorbance over the HEV band (380-450 nm) than the control product and the other commercial sunscreens. All the sunscreens tested showed the same level of absorbance at 365 nm (UVA).
CONCLUSIONS
CONCLUSIONS
Multispectral imaging provides a simple and reliable in vivo method for assessing the real-world protection provided by sunscreens against all forms of photo-induced skin damage, including that induced by HEV radiation.
Substances chimiques
Sunscreening Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6-11Subventions
Organisme : Pierre Fabre Dermo-Cosmétique
Informations de copyright
© 2023 European Academy of Dermatology and Venereology.
Références
Sliney DH. What is light? The visible spectrum and beyond. Eye (Lond). 2016;30:222-9.
MacLaughlin JA, Anderson RR, Holick MF. Spectral character of sunlight modulates photosynthesis of previtamin D3 and its photoisomers in human skin. Science. 1982;216:1001-3.
Melnikova VO, Ananthaswamy HN. Cellular and molecular events leading to the development of skin cancer. Mutat Res. 2005;571:91-106.
Trautinger F. Mechanisms of photodamage of the skin and its functional consequences for skin ageing. Clin Exp Dermatol. 2001;26:573-7.
Mouret S, Forestier A, Douki T. The specificity of UVA-induced DNA damage in human melanocytes. Photochem Photobiol Sci. 2012;11:155-62.
Nakashima Y, Ohta S, Wolf AM. Blue light-induced oxidative stress in live skin. Free Radic Biol Med. 2017;108:300-10.
Tonolli PN, Chiarelli-Neto O, Santacruz-Perez C, Junqueira HC, Watanabe IS, Ravagnani FG, et al. Lipofuscin generated by UVA turns keratinocytes photosensitive to visible light. J Invest Dermatol. 2017;137:2447-50.
Lohan SB, Müller R, Albrecht S, Mink K, Tscherch K, Ismaeel F, et al. Free radicals induced by sunlight in different spectral regions - in vivo versus ex vivo study. Exp Dermatol. 2016;25:380-5.
Duteil L, Cardot-Leccia N, Queille-Roussel C, Maubert Y, Harmelin Y, Boukari F, et al. Differences in visible light-induced pigmentation according to wavelengths: a clinical and histological study in comparison with UVB exposure. Pigment Cell Melanoma Res. 2014;27:822-6.
Krutmann J, Berneburg M. Sun-damaged skin (photoaging): what is new? Hautarzt. 2021;72:2-5.
Krutmann J, Passeron T, Gilaberte Y, Granger C, Leone G, Narda M, et al. Photoprotection of the future: challenges and opportunities. J Eur Acad Dermatol Venereol. 2020;34:447-54.
Bacqueville D, Jacques-Jamin C, Dromigny H, Boyer F, Redoulès D, Bessou-Touya S, et al. 512 Phenylene bis-diphenyltriazine (TriAsorB), a new full-spectrum photoprotector against sunlight radiation induced skin damage. J Invest Dermatol. 2021;141:S89.
Kubelka P, Munk F. An article on optics of paint layers. Z Tech Phys. 1931;12:259-74.
Szepietowski JC, Nowicka D, Reich A, Melon M. Application of sunscreen preparations among young Polish people. J Cosmet Dermatol. 2004;3:69-72.
Nishino K, Haryu Y, Kinoshita A, Nakauchi S. Development of the multispectral UV polarization reflectance imaging system (MUPRIS) for in situ monitoring of the UV protection efficacy of sunscreen on human skin. Skin Res Technol. 2019;25:639-52.
Josse G, Le Digabel J. Pierre Fabre Dermo-Cosmétique. Device for characterising and comparing erythemal zones. WO/2020/148454 July 23, 2020. European Patent Bulletin 2021;47.
Throm CM, Wiora G, Reble C, Schleusener J, Schanzer S, Karrer H, et al. In vivo sun protection factor and UVA protection factor determination using (hybrid) diffuse reflectance spectroscopy and a multi-lambda-LED light source. J Biophotonics. 2021;14:e202000348.
Bernstein EF, Sarkas HW, Boland P. Iron oxides in novel skin care formulations attenuate blue light for enhanced protection against skin damage. J Cosmet Dermatol. 2021;20:532-7.
Cole C, Shyr T, Ou-Yang H. Metal oxide sunscreens protect skin by absorption, not by reflection or scattering. Photodermatol Photoimmunol Photomed. 2016;32:5-10.