Bacteria-Based Backpacks to Enhance Adoptive Macrophage Transfer against Solid Tumors.
backpacks
bacteria
immunotherapy
macrophages
tumor
Journal
Advanced materials (Deerfield Beach, Fla.)
ISSN: 1521-4095
Titre abrégé: Adv Mater
Pays: Germany
ID NLM: 9885358
Informations de publication
Date de publication:
06 Sep 2023
06 Sep 2023
Historique:
revised:
12
08
2023
received:
05
06
2023
pubmed:
6
9
2023
medline:
6
9
2023
entrez:
6
9
2023
Statut:
aheadofprint
Résumé
Adoptive cell therapy has emerged as a promising approach for cancer treatment. However, the transfer of macrophages exhibits limited efficacy against solid tumors due to the dynamic cellular phenotypic shift from antitumor to protumor states within the immunosuppressive tumor microenvironment. In this study, a strategy of attaching bacteria to macrophages (Mø@bac) is reported that endows adoptively infused macrophages with durable stimulation by leveraging the intrinsic immunogenicity of bacteria. These attached bacteria, referred to as backpacks, are encapsulated with adhesive nanocoatings and can sustainably control the cellular phenotypes in vivo. Moreover, Mø@bac can repolarize endogenous tumor-associated macrophages, leading to a more robust immune response and thus reducing the tumor progression in a murine 4T1 cancer model without any side effects. This study utilizing bacteria as cellular backpacks opens a new avenue for the development of cell therapies.
Identifiants
pubmed: 37672674
doi: 10.1002/adma.202305384
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2305384Subventions
Organisme : National Key Research and Development Program of China
ID : 2019YFA0905603
Organisme : National Natural Science Foundation of China
ID : 51988102
Organisme : National Natural Science Foundation of China
ID : 21721005
Organisme : National Natural Science Foundation of China
ID : 22135005
Informations de copyright
© 2023 Wiley-VCH GmbH.
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