X-ray-controllable release of carbon monoxide potentiates radiotherapy by ultrastable hybrid nanoreservoirs.

Carbon Monoxide X-Rays Hydrogen Peroxide Metals Silicon Dioxide
Carbon monoxide Fenton-like reaction Nanoreservoir Peritoneal carcinomatosis Radiotherapy

Journal

Biomaterials
ISSN: 1878-5905
Titre abrégé: Biomaterials
Pays: Netherlands
ID NLM: 8100316

Informations de publication

Date de publication:
11 2023
Historique:
received: 06 06 2023
revised: 23 08 2023
accepted: 01 09 2023
medline: 6 11 2023
pubmed: 7 9 2023
entrez: 6 9 2023
Statut: ppublish

Résumé

Carbon monoxide (CO) exhibits unique abilities in sensitizing cancer radiotherapy (RT). However, the development of a highly stable CO-delivery nanosystem with sustained CO release in tumor tissues and the prevention of CO leakage into normal tissues remains a challenge. Herein, an organic-inorganic hybrid strategy is proposed to create ultrastable CO nanoreservoirs by locking an unstable iron carbonyl (FeCO) prodrug in a stable mesoporous silica matrix. Different from traditional FeCO-loading nanoplatforms, FeCO-bridged nanoreservoirs not only tethered labile FeCO in the framework to prevent unwanted FeCO leakage, but also achieved sustained CO release in response to X-ray and endogenous H

Identifiants

DOI: 10.1016/j.biomaterials.2023.122313 PMID: 37672998
pubmed: 37672998
pii: S0142-9612(23)00321-6
doi: 10.1016/j.biomaterials.2023.122313
pii:
doi:

Substances chimiques

Carbon Monoxide 7U1EE4V452
Hydrogen Peroxide BBX060AN9V
Metals 0
Silicon Dioxide 7631-86-9

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

122313

Informations de copyright

Copyright © 2023 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Junna Lu (J)

School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangdong, 510006, China; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangdong, 510006, China.

Fangman Chen (F)

School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangdong, 510006, China; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangdong, 510006, China. Electronic address: chenfangman@hotmail.com.

Xiaochun Xie (X)

School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangdong, 510006, China; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangdong, 510006, China.

Ziping Wu (Z)

School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangdong, 510006, China; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangdong, 510006, China.

Yinglu Chen (Y)

School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangdong, 510006, China; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangdong, 510006, China.

Yidan Zhang (Y)

School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangdong, 510006, China; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangdong, 510006, China.

Hui Fang (H)

School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangdong, 510006, China; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangdong, 510006, China.

Feixia Ruan (F)

School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangdong, 510006, China; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangdong, 510006, China.

Dan Shao (D)

School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangdong, 510006, China; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangdong, 510006, China.

Zheng Wang (Z)

CAS Key Laboratory of Nano-Bio Interface Suzhou Institute of Nano-Tech and NanoBionics Chinese Academy of Sciences, Suzhou, 215123, China. Electronic address: zwang2021@sinano.ac.cn.

Renjun Pei (R)

CAS Key Laboratory of Nano-Bio Interface Suzhou Institute of Nano-Tech and NanoBionics Chinese Academy of Sciences, Suzhou, 215123, China. Electronic address: rjpei2011@sinano.ac.cn.

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Classifications MeSH

questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Monoxyde de carbone › X-ray-controllable release of carbon monoxide...
questionsmedicales.fr › Phénomènes physiques › Rayonnement › Rayonnement ionisant › Rayons X › X-ray-controllable release of carbon monoxide...
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Peroxyde d'hydrogène › X-ray-controllable release of carbon monoxide...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › X-ray-controllable release of carbon monoxide...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du silicium › Silice › X-ray-controllable release of carbon monoxide...