A Bioartificial Pancreas with "Immune Stealth" and Continuous Oxygen Supply for Islet Transplantation.
antifibrinogen adhesion
bioartificial pancreas
immune stealth
microencapsulated islet cells
oxygen supply
Journal
Macromolecular rapid communications
ISSN: 1521-3927
Titre abrégé: Macromol Rapid Commun
Pays: Germany
ID NLM: 9888239
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
revised:
02
09
2023
received:
28
06
2023
medline:
11
12
2023
pubmed:
7
9
2023
entrez:
6
9
2023
Statut:
ppublish
Résumé
Transplantation of microencapsulated islet cells remains a promising strategy for the normalization of glucose metabolism control in type 1 diabetes mellitus. However, vigorous host immunologic rejection, fibrotic overgrowth around the microcapsules, and poor oxygen supply often lead to graft failure. Herein, a bioartificial pancreas is constructed, which incorporates the "stealth effect" based on polyethylene glycol copolymers and the high oxygen-carrying performance of fluorinated nanoparticles. Polycationic poly(l-lysine)-grafted-poly(ethylene glycol) is successfully coated on the surface of alginate microcapsules through electrostatic interaction, which can not only resist fibrinogen adhesion and avoid excessive fibrosis around the microcapsules but also isolate the host immune system from attacking, achieving a "stealth effect" of microencapsulated islet cells. Furthermore, the coloading of fluoride-based O
Identifiants
pubmed: 37673078
doi: 10.1002/marc.202300383
doi:
Substances chimiques
Capsules
0
Polyethylene Glycols
3WJQ0SDW1A
Oxygen
S88TT14065
Insulin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2300383Subventions
Organisme : National Natural Science Foundation of China
ID : 32171339
Organisme : Joint Fund for Innovation and Development of Shandong Provincial Natural Science Foundation
ID : ZR2022LZY028
Organisme : Taishan Scholars Program of Shandong Province
ID : tstp20221161
Organisme : Postdoctoral Innovation Talents Support Program of Shandong
ID : SDBX2022013
Informations de copyright
© 2023 Wiley-VCH GmbH.
Références
G. Mancuso, C. Bechi Genzano, A. Fierabracci, G. Fousteri, J. Allergy Clin. Immunol. 2023, 151, 1429.
Å. Lernmark, B. Akolkar, W. Hagopian, J. Krischer, R. McIndoe, M. Rewers, J. Toppari, K. Vehik, A. Ziegler, J. Intern. Med. 2023, 294, 145.
K. Dovc, S. Lanzinger, R. Cardona-Hernandez, M. Tauschmann, M. Marigliano, V. Cherubini, R. Preikša, U. Schierloh, H. Clapin, F. AlJaser, J. Pelicand, R. Shukla, T. Biester, JAMA Netw Open 2023, 6, e230077.
G. Iacobucci, BMJ 2023, 380, p55.
C. Pihoker, B. H. Braffett, T. J. Songer, W. H. Herman, M. Tung, S. Kuo, A. Bellatorre, E. Isganaitis, E. T. Jensen, J. Divers, P. Zhang, D. M. Nathan, K. Drews, D. Dabelea, P. S. Zeitler, JAMA Network Open 2023, 6, e2312147.
G. Iacobucci, BMJ 2023, 380, p55.
N. J. Hogrebe, M. Ishahak, J. R. Millman, Cell Stem Cell 2023, 30, 530.
J. M. Gammon, S. T. Carey, V. Saxena, H. B. Eppler, S. J. Tsai, C. Paluskievicz, Y. Xiong, L. Li, M. Ackun-Farmmer, L. H. Tostanoski, E. A. Gosselin, A. A. Yanes, X. Zeng, R. S. Oakes, J. S. Bromberg, C. M. Jewell, Nat. Commun. 2023, 14, 681.
S. Forbes, P. A. Senior, A. M. J. Shapiro, Lancet Diabetes Endocrinol. 2018, 6, 516.
H. Derakhshankhah, S. Sajadimajd, F. Jahanshahi, Z. Samsonchi, H. Karimi, E. Hajizadeh-Saffar, S. Jafari, M. Razmi, S. S. Malvajerd, G. Bahrami, M. Razavi, Z. Izadi, Tissue Eng., Part B 2023, 28, 1053.
A. Kale, N. M. Rogers, Cells 2023, 12, 796.
S. N. Marikar, A. El-Osta, A. Johnston, G. Such, K. Al-Hasani, Cell. Mol. Life Sci. 2023, 79, 351.
Q.i Zhang, C. Gonelle-Gispert, Y. Li, Z. Geng, S. Gerber-Lemaire, Y.i Wang, L. Buhler, Front. Immunol. 2022, 13, 869984.
T. Long, W. Tan, X. Tian, Z. Tang, K. Hu, L. Ge, C. Mu, X. Li, Y. Xu, L. Zhao, D. Li, Int. J. Biol. Macromol. 2023, 226, 485.
J. K. Wang, N. M. J. Cheam, S. A. Irvine, N. S. Tan, S. Venkatraman, C. Y. Tay, Macromol. Rapid Commun. 2020, 41, 2000275.
X. Wang, K. Wang, W. Zhang, M. Qiang, Y. Luo, Biomaterials 2017, 138, 80.
D. Wang, Y. Zhu, Y. Huang, J. Zhu, B. Zhu, Y. Zhao, Y. Lu, Z. Wang, Y. Guo, ACS Biomater. Sci. Eng. 2021, 7, 3793.
L. Fath-Bayati, J. Ai, J. Biomed. Mater. Res., Part A 2019, 108, 94.
D. M. Grant, A. Macedo, D. Toms, C. Klein, Biol. Reprod. 2019, 102, 170.
B. E. Tuch, G. W. Keogh, L. J. Williams, W. Wu, J. L. Foster, V. Vaithilingam, R. Philips, Diabetes Care 2009, 32, 1887.
Z. Wang, Z. Jiang, R. Lu, L. Kou, Y.-Z. Zhao, Q. Yao, Eur. J. Pharm. Biopharm. 2023, 187, 130.
S. E. Bachert, P. Dogra, L. I. Boral, Am. J. Clin. Pathol. 2020, 153, 287.
H. Hu, X. Yan, H. Wang, J. Tanaka, M. Wang, W. You, Z. Li, J. Mater. Chem. B 2019, 7, 1116.
Ý. A. Mørch, I. Donati, B. L. Strand, G. Skjåk-Braek, Biomacromolecules 2006, 7, 1471.
A. E. Coron, J. S. Kjesbu, F. Kjaernsmo, J. Oberholzer, A. M. A. Rokstad, B. L. Strand, Acta Biomater. 2022, 137, 172.
N. H. Sulimai, J. Brown, D. Lominadze, Biomedicines 2022, 10, 1712.
J. Y. Hsieh, T. D. Smith, V. S. Meli, T. N. Tran, E. L. Botvinick, W. F. Liu, Acta Biomater. 2017, 47, 14.
M. Li, S. Jiang, J. Simon, D. Paßlick, M.-L. Frey, M. Wagner, V. Mailänder, D. Crespy, K. Landfester, Nano Lett. 2021, 21, 1591.
D. Y. Joh, Z. Zimmers, M. Avlani, J. T. Heggestad, H. B. Aydin, N. Ganson, S. Kumar, C. M. Fontes, R. K. Achar, M. S. Hershfield, A. M. Hucknall, A. Chilkoti, Adv. Healthcare Mater. 2019, 8, 1801177.
M. Wang, S. Lin, M. Liu, J. Jiao, H. Mi, J. Sun, Y. Liu, R. Guo, S. Liu, H. Fu, Y. Yang, R. Li, Chem. Eng. J. 2023, 463, 142283.
J. Kil, R. T. Rahman, W. Wang, S. Choi, Y. S. Nam, S. Li, J. Mater. Chem. B 2023, 11, 2904.
W. Chu, H. Tang, Z. Dong, A. Hou, R. Qiu, X. Xu, J. Yang, L. He, J. Luo, J. Li, J. Mater. Chem. B 2023, 11, 5151.
A. Mamilos, L. Winter, V. H. Schmitt, F. Barsch, D. Grevenstein, W. Wagner, M. Babel, K. Keller, C. Schmitt, F. Gürtler, S. Schreml, T. Niedermair, M. Rupp, V. Alt, C. Brochhausen, Cells 2023, 12, 276.
Z. Wang, W. You, W. Wang, W. Tian, F. Chen, Y. Xiao, Y. Chen, X. Wang, Adv. Fiber Mater. 2022, 4, 1556.
X. Wu, A. Zhou, Y. Zhang, J. He, K. Chen, X. Ning, Y. Xu, ACS Appl. Mater. Interfaces 2023, 15, 6456.
Z. Dong, P. Liang, G. Guan, B. Yin, Y. Wang, R. Yue, X. Zhang, G. Song, Angew. Chem., Int. Ed. Engl. 2022, 61, 202206074.
M. P. Krafft, J. G. Riess, Adv. Colloid Interface Sci. 2021, 294, 102407.
A. Espona-Noguera, J. Etxebarria-Elezgarai, L. Saenz Del Burgo, A. Cañibano-Hernández, H. Gurruchaga, F. J. Blanco, G. Orive, R. M. Hernández, F. Benito-Lopez, J. Ciriza, L. Basabe-Desmonts, J. L. Pedraz, Int. J. Pharm. 2019, 560, 65.