Co-administration of amoxicillin-loaded chitosan nanoparticles and inulin: A novel strategy for mitigating antibiotic resistance and preserving microbiota balance in Helicobacter pylori treatment.
Amoxicillin
Antibiotic resistance
Chitosan nanoparticles
H. pylori
Inulin
L. casei
hefA
Journal
International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578
Informations de publication
Date de publication:
31 Dec 2023
31 Dec 2023
Historique:
received:
06
07
2023
revised:
25
08
2023
accepted:
03
09
2023
medline:
27
11
2023
pubmed:
7
9
2023
entrez:
6
9
2023
Statut:
ppublish
Résumé
Helicobacter pylori (H. pylori) is a causative agent of various gastrointestinal diseases and eradication mainly relies on antibiotic treatment, with (AMX) being a key component. However, rising antibiotic resistance in H. pylori necessitates the use of antibiotics combination therapy, often disrupting gut microbiota equilibrium leading to further health complications. This study investigates a novel strategy utilizing AMX-loaded chitosan nanoparticles (AMX-CS NPs), co-administered with prebiotic inulin to counteract H. pylori infection while preserving microbiota health. Following microbroth dilution method, AMX displayed efficacy against H. pylori, with a MIC
Identifiants
pubmed: 37673144
pii: S0141-8130(23)03603-6
doi: 10.1016/j.ijbiomac.2023.126706
pii:
doi:
Substances chimiques
Amoxicillin
804826J2HU
Chitosan
9012-76-4
Inulin
9005-80-5
Anti-Bacterial Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
126706Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this article.