Co-loading of Temozolomide with Oleuropein or rutin into polylactic acid core-shell nanofiber webs inhibit glioblastoma cell by controlled release.
Combined treatment
Glioblastoma local treatment
Nano-based drug delivery systems
Journal
International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578
Informations de publication
Date de publication:
31 Dec 2023
31 Dec 2023
Historique:
received:
01
06
2023
revised:
31
08
2023
accepted:
03
09
2023
medline:
27
11
2023
pubmed:
7
9
2023
entrez:
6
9
2023
Statut:
ppublish
Résumé
Glioblastoma (GB) has susceptibility to post-surgical recurrence. Therefore, local treatment methods are required against recurrent GB cells in the post-surgical area. In this study, we developed a nanofiber-based local therapy against GB cells using Oleuropein (OL), and rutin and their combinations with Temozolomide (TMZ). The polylactic acid (PLA) core-shell nanofiber webs were encapsulated with OL (PLA
Identifiants
pubmed: 37673167
pii: S0141-8130(23)03619-X
doi: 10.1016/j.ijbiomac.2023.126722
pii:
doi:
Substances chimiques
Temozolomide
YF1K15M17Y
poly(lactide)
459TN2L5F5
oleuropein
2O4553545L
Delayed-Action Preparations
0
Rutin
5G06TVY3R7
Polyesters
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
126722Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Berrin Tunca reports financial support was provided by Scientific and Technological Research Council of Turkey (TUBITAK).