Comprehensive analyses of fatty acid metabolism-related lncRNA for ovarian cancer patients.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
06 09 2023
06 09 2023
Historique:
received:
30
01
2023
accepted:
15
05
2023
medline:
8
9
2023
pubmed:
7
9
2023
entrez:
6
9
2023
Statut:
epublish
Résumé
Ovarian cancer (OC) is a disease with difficult early diagnosis and treatment and poor prognosis. OC data profiles were downloaded from The Cancer Genome Atlas. Eight key fatty acid metabolism-related long non-coding RNAs (lncRNAs) were finally screened for building a risk scoring model by univariate/ multifactor and least absolute shrinkage and selection operator (LASSO) Cox regression. To make this risk scoring model more applicable to clinical work, we established a nomogram containing the clinical characteristics of OC patients after confirming that the model has good reliability and validity and the ability to distinguish patient prognosis. To further explore how these key lncRNAs are involved in OC progression, we explored their relationship with LUAD immune signatures and tumor drug resistance. The structure shows that the risk scoring model established based on these 8 fatty acid metabolism-related lncRNAs has good reliability and validity and can better predict the prognosis of patients with different risks of OC, and LINC00861in these key RNAs may be a hub gene that affects the progression of OC and closely related to the sensitivity of current OC chemotherapy drugs. In addition, combined with immune signature analysis, we found that patients in the high-risk group are in a state of immunosuppression, and Tfh cells may play an important role in it. We innovatively established a prognostic prediction model with excellent reliability and validity from the perspective of OC fatty acid metabolism reprogramming and lncRNA regulation and found new molecular/cellular targets for future OC treatment.
Identifiants
pubmed: 37673886
doi: 10.1038/s41598-023-35218-0
pii: 10.1038/s41598-023-35218-0
pmc: PMC10482851
doi:
Substances chimiques
RNA, Long Noncoding
0
Fatty Acids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
14675Informations de copyright
© 2023. Springer Nature Limited.
Références
Immunity. 2008 Jul 18;29(1):138-49
pubmed: 18599325
Cell Metab. 2016 Jan 12;23(1):27-47
pubmed: 26771115
Nat Med. 2020 Jun;26(6):919-931
pubmed: 32451498
Sci Rep. 2021 Apr 13;11(1):8069
pubmed: 33850225
Int J Mol Sci. 2022 Feb 16;23(4):
pubmed: 35216285
CA Cancer J Clin. 2019 Jul;69(4):280-304
pubmed: 31099893
BMC Med Genet. 2019 Jun 10;20(1):103
pubmed: 31182053
J Hematol Oncol. 2021 Oct 29;14(1):178
pubmed: 34715882
Front Oncol. 2020 Jan 21;9:1549
pubmed: 32039022
Life Sci. 2020 Nov 1;260:118305
pubmed: 32827544
Lancet. 2014 Oct 11;384(9951):1376-88
pubmed: 24767708
Cell Mol Life Sci. 2016 Jan;73(2):377-92
pubmed: 26499846
Lipids Health Dis. 2020 Oct 13;19(1):222
pubmed: 33050938
Cell Metab. 2022 Mar 1;34(3):355-377
pubmed: 35123658
Clin Cancer Res. 2018 Jun 1;24(11):2482-2490
pubmed: 29420223
Cancer Manag Res. 2018 Dec 05;10:6685-6693
pubmed: 30584363
Cancer Cell Int. 2021 Jul 8;21(1):363
pubmed: 34238292
Nucleic Acids Res. 2023 Jan 6;51(D1):D587-D592
pubmed: 36300620
Nature. 2021 Nov;599(7883):91-95
pubmed: 34707284
Nat Rev Cancer. 2021 Mar;21(3):162-180
pubmed: 33462499
Cytokine. 2012 May;58(2):133-47
pubmed: 22349527
J Exp Clin Cancer Res. 2019 Sep 18;38(1):411
pubmed: 31533774
Immunity. 2022 Jan 11;55(1):115-128.e9
pubmed: 35021053
Theranostics. 2021 Jul 13;11(17):8322-8336
pubmed: 34373744
Lancet. 2019 Mar 23;393(10177):1240-1253
pubmed: 30910306
Nat Methods. 2015 May;12(5):453-7
pubmed: 25822800
CA Cancer J Clin. 2020 Jan;70(1):7-30
pubmed: 31912902
Cancer Res. 2018 Jul 1;78(13):3484-3496
pubmed: 29588351
J Exp Med. 2009 May 11;206(5):991-9
pubmed: 19380637
Med Oncol. 2015 Jan;32(1):391
pubmed: 25433947
Cancers (Basel). 2020 Aug 03;12(8):
pubmed: 32756436
Oncogenesis. 2020 Feb 7;9(2):14
pubmed: 32034121
Nat Commun. 2021 Nov 16;12(1):6618
pubmed: 34785669
Theranostics. 2021 Jan 1;11(5):2201-2217
pubmed: 33500720
J Ovarian Res. 2021 Nov 11;14(1):153
pubmed: 34758846
Nat Rev Immunol. 2015 Mar;15(3):149-59
pubmed: 25677494
Front Genet. 2022 Mar 21;13:844709
pubmed: 35480323
J Ovarian Res. 2019 Mar 27;12(1):28
pubmed: 30917847
Int Immunopharmacol. 2019 Mar;68:81-87
pubmed: 30616170
Ann Intern Med. 2020 Nov 3;173(9):704-713
pubmed: 32866413
Cancers (Basel). 2019 Jul 05;11(7):
pubmed: 31284467
Cell. 2018 Apr 5;173(2):530
pubmed: 29625059
Front Genet. 2021 Nov 22;12:779554
pubmed: 34880908
Aging (Albany NY). 2020 Sep 14;12(17):17122-17136
pubmed: 32927431
Nat Rev Cancer. 2016 Oct;16(10):650-62
pubmed: 27634448
Oncotarget. 2016 Jun 14;7(24):37390-37406
pubmed: 27119509
Front Immunol. 2020 Oct 06;11:577869
pubmed: 33123161
Oncogene. 2021 Jan;40(4):833-847
pubmed: 33273726
Semin Cancer Biol. 2021 Jan;68:132-142
pubmed: 31904426
Nat Rev Urol. 2020 Apr;17(4):232-250
pubmed: 32071434
Protein Sci. 2019 Nov;28(11):1947-1951
pubmed: 31441146
N Engl J Med. 2020 Feb 27;382(9):869-871
pubmed: 32101671
Front Oncol. 2020 Oct 19;10:593017
pubmed: 33194756
Int J Mol Sci. 2020 Nov 23;21(22):
pubmed: 33238475
Aging (Albany NY). 2021 Nov 18;13(22):24621-24639
pubmed: 34799469
Cell. 2021 Dec 9;184(25):6101-6118.e13
pubmed: 34852236
Arch Biochem Biophys. 2020 May 15;684:108334
pubmed: 32173334
Int J Cancer. 2018 Aug 15;143(4):992-1002
pubmed: 29569717
Mol Med Rep. 2021 Jan;23(1):
pubmed: 33179755
Adv Exp Med Biol. 2017;1008:1-46
pubmed: 28815535
J Exp Clin Cancer Res. 2018 Jun 19;37(1):120
pubmed: 29921308
Semin Cancer Biol. 2022 Nov;86(Pt 2):568-579
pubmed: 35378273
Nucleic Acids Res. 2000 Jan 1;28(1):27-30
pubmed: 10592173
Mol Cell Biochem. 2020 Jan;464(1-2):39-50
pubmed: 31691157
Front Mol Biosci. 2021 Nov 25;8:763902
pubmed: 34901157
Nat Commun. 2021 Jun 22;12(1):3830
pubmed: 34158490
EPMA J. 2021 Oct 21;12(4):589-604
pubmed: 34950253
Nutrients. 2019 Oct 02;11(10):
pubmed: 31581675
Cell Death Dis. 2020 Jan 13;11(1):25
pubmed: 31932581
Eur J Immunol. 2014 Jun;44(6):1814-22
pubmed: 24510590