Significance and Influence of Suturing for Ovarian Tissue Transplantation.
Fertility preservation
Ovarian tissue transplantation
Postoperative ovarian function
Suturing technique
Journal
Reproductive sciences (Thousand Oaks, Calif.)
ISSN: 1933-7205
Titre abrégé: Reprod Sci
Pays: United States
ID NLM: 101291249
Informations de publication
Date de publication:
06 Sep 2023
06 Sep 2023
Historique:
received:
09
04
2023
accepted:
01
08
2023
medline:
7
9
2023
pubmed:
7
9
2023
entrez:
6
9
2023
Statut:
aheadofprint
Résumé
The purpose of this animal study was to verify the effect of suturing on graft function in ovarian tissue transplantation. Ovaries from 2-week-old rats were transplanted orthotopically into the ovaries of 8-week-old female Wistar rats. The various transplantation methods used were insertion into the ovarian bursa without suturing (group A: control), suturing with a single 6-0 Vicryl stitch (group B: 6-0*1), suturing with a single 10-0 Vicryl stitch (group C: 10-0*1), and suturing with three 10-0 Vicryl stitches (group D: 10-0*3). Two weeks after transplantation, the transplanted ovaries were evaluated histologically and for gene expression. Engraftment rates of the donor ovaries 14 days after transplantation were 62.5%, 100%, 91.7%, and 100% in groups A, B, C, and D, respectively, significantly lower in group A than in the other groups. In terms of gene expression, TNFα levels were significantly higher in group D, and GDF9 and follicle-stimulating hormone receptor (FSHR) levels were significantly lower in group D than in groups A and B. The number of primordial follicles evaluated by HE staining was significantly lower in groups B, C, and D than in group A. Compared to orthotopic transplantation without sutures, direct suturing to the host improved the engraftment rate, although increasing the number of sutures increased inflammatory marker levels and decreased the number of primordial follicles. We believe that it is important to perform ovarian tissue transplantation using optimal suture diameter for good adhesion, but with a minimum number of sutures to preserve ovarian function.
Identifiants
pubmed: 37674005
doi: 10.1007/s43032-023-01320-x
pii: 10.1007/s43032-023-01320-x
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2023. The Author(s), under exclusive licence to Society for Reproductive Investigation.
Références
Ethics Committee of the American Society for Reproductive Medicine. Fertility preservation and reproduction in patients facing gonadotoxic therapies: an Ethics Committee opinion. Fertil Steril. 2018;110:380–6. https://doi.org/10.1016/j.fertnstert.2018.05.034 .
doi: 10.1016/j.fertnstert.2018.05.034
Oktay K, Marin L, Bedoschi G, et al. Ovarian transplantation with robotic surgery and a neovascularizing human extracellular matrix scaffold: a case series in comparison to meta-analytic data. Fertil Steril. 2022;117:181–92. https://doi.org/10.1016/j.fertnstert.2021.08.034 .
doi: 10.1016/j.fertnstert.2021.08.034
pubmed: 34801235
Oktay K, Economos K, Kan M, Rucinski J, Veeck L, Rosenwaks Z. Endocrine function and oocyte retrieval after autologous transplantation of ovarian cortical strips to the forearm. JAMA. 2001;286:1490–3. https://doi.org/10.1001/jama.286.12.1490 .
doi: 10.1001/jama.286.12.1490
pubmed: 11572742
Oktay K, Karlikaya G. Ovarian function after transplantation of frozen, banked autologous ovarian tissue. N Engl J Med. 2000;342:1919. https://doi.org/10.1056/NEJM200006223422516 .
doi: 10.1056/NEJM200006223422516
pubmed: 10877641
Kiran G, Kiran H, Coban YK, Guven AM, Yuksel M. Fresh autologous transplantation of ovarian cortical strips to the anterior abdominal wall at the pfannenstiel incision site. Fertil Steril. 2004;82:954–6. https://doi.org/10.1016/j.fertnstert.2004.06.007 .
doi: 10.1016/j.fertnstert.2004.06.007
pubmed: 15482779
Dolmans MM, von Wolff M, Poirot C, et al. Transplantation of cryopreserved ovarian tissue in a series of 285 women: a review of five leading European centers. Fertil Steril. 2021;115:1102–15. https://doi.org/10.1016/j.fertnstert.2021.03.008 .
doi: 10.1016/j.fertnstert.2021.03.008
pubmed: 33933173
Baird DT, Webb R, Campbell BK, Harkness LM, Gosden RG. Long-term ovarian function in sheep after ovariectomy and transplantation of autografts stored at -196 C. Endocrinology. 1999;140:462–71. https://doi.org/10.1210/endo.140.1.6453 .
doi: 10.1210/endo.140.1.6453
pubmed: 9886858
Nisolle M, Casanas-Roux F, Qu J, Motta P, Donnez J. Histologic and ultrastructural evaluation of fresh and frozen-thawed human ovarian xenografts in nude mice. Fertil Steril. 2000;74:122–9. https://doi.org/10.1016/s0015-0282(00)00548-3 .
doi: 10.1016/s0015-0282(00)00548-3
pubmed: 10899508
Roness H, Meirow D. FERTILITY PRESERVATION: follicle reserve loss in ovarian tissue transplantation. Reproduction. 2019;158:F35–44. https://doi.org/10.1530/REP-19-0097 .
doi: 10.1530/REP-19-0097
pubmed: 31394506
Aubard Y, Piver P, Cogni Y, Fermeaux V, Poulin N, Driancourt MA. Orthotopic and heterotopic autografts of frozen-thawed ovarian cortex in sheep. Hum Reprod. 1999;14:2149–54. https://doi.org/10.1093/humrep/14.8.2149 .
doi: 10.1093/humrep/14.8.2149
pubmed: 10438442
Greve T, Schmidt KT, Kristensen SG, Ernst E, Andersen CY. Evaluation of the ovarian reserve in women transplanted with frozen and thawed ovarian cortical tissue. Fertil Steril. 2012;97:1394–8. https://doi.org/10.1016/j.fertnstert.2012.02.036 .
doi: 10.1016/j.fertnstert.2012.02.036
pubmed: 22425199
Gavish Z, Peer G, Roness H, Cohen Y, Meirow D. Follicle activation and ‘burn-out’ contribute to post-transplantation follicle loss in ovarian tissue grafts: the effect of graft thickness. Hum Reprod. 2014;29:989–96. https://doi.org/10.1093/humrep/deu015 .
doi: 10.1093/humrep/deu015
pubmed: 24522758
Souza SS, Aguiar FLN, Alves BG, et al. Equine ovarian tissue xenografting: impacts of cooling, vitrification, and VEGF. Reprod Fertil. 2021;2:251–66. https://doi.org/10.1530/RAF-21-0008 .
doi: 10.1530/RAF-21-0008
pubmed: 35118403
pmcid: 8801023
Takae S, Suzuki N. Current state and future possibilities of ovarian tissue transplantation. Reprod Med Biol. 2019;18:217–24. https://doi.org/10.1002/rmb2.12268 .
doi: 10.1002/rmb2.12268
pubmed: 31312099
pmcid: 6613018
Oktay KH, Marin L, Petrikovsky B, Terrani M, Babayev SN. Delaying reproductive aging by ovarian tissue cryopreservation and transplantation: is it prime time? Trends Mol Med. 2021;27:753–61. https://doi.org/10.1016/j.molmed.2021.01.005 .
doi: 10.1016/j.molmed.2021.01.005
pubmed: 33549473
pmcid: 8427891
Silber SJ, DeRosa M, Pineda J, et al. A series of monozygotic twins discordant for ovarian failure: ovary transplantation (cortical versus microvascular) and cryopreservation. Hum Reprod. 2008;23:1531–7. https://doi.org/10.1093/humrep/den032 .
doi: 10.1093/humrep/den032
pubmed: 18285322
Shikanov A, Zhang Z, Xu M, et al. Fibrin encapsulation and vascular endothelial growth factor delivery promotes ovarian graft survival in mice. Tissue Eng Part A. 2011;17:3095–104. https://doi.org/10.1089/ten.TEA.2011.0204 .
doi: 10.1089/ten.TEA.2011.0204
pubmed: 21740332
pmcid: 3226061
Pedersen T, Peters H. Proposal for a classification of oocytes and follicles in the mouse ovary. J Reprod Fertil. 1968;17:555–7. https://doi.org/10.1530/jrf.0.0170555 .
doi: 10.1530/jrf.0.0170555
pubmed: 5715685
Gavish Z, Spector I, Peer G, et al. Follicle activation is a significant and immediate cause of follicle loss after ovarian tissue transplantation. J Assist Reprod Genet. 2018;35:61–9. https://doi.org/10.1007/s10815-017-1079-z .
doi: 10.1007/s10815-017-1079-z
pubmed: 29098533
Liu J, Van der Elst J, Van den Broecke R, Dhont M. Early massive follicle loss and apoptosis in heterotopically grafted newborn mouse ovaries. Hum Reprod. 2002;17:605–11. https://doi.org/10.1093/humrep/17.3.605 .
doi: 10.1093/humrep/17.3.605
pubmed: 11870111
Dolmans MM, Martinez-Madrid B, Gadisseux E, et al. Short-term transplantation of isolated human ovarian follicles and cortical tissue into nude mice. Reproduction. 2007;134:253–62. https://doi.org/10.1530/REP-07-0131 .
doi: 10.1530/REP-07-0131
pubmed: 17660235
von Schönfeldt V, Chandolia R, Ochsenkühn R, Nieschlag E, Kiesel L, Sonntag B. FSH prevents depletion of the resting follicle pool by promoting follicular number and morphology in fresh and cryopreserved primate ovarian tissues following xenografting. Reprod Biol Endocrinol. 2012;10:98. https://doi.org/10.1186/1477-7827-10-98 .
doi: 10.1186/1477-7827-10-98
Soleimani R, Heytens E, Van den Broecke R, et al. Xenotransplantation of cryopreserved human ovarian tissue into murine back muscle. Hum Reprod. 2010;25:1458–70. https://doi.org/10.1093/humrep/deq055 .
doi: 10.1093/humrep/deq055
pubmed: 20299384
Oktay K, Buyuk E, Veeck L, et al. Embryo development after heterotopic transplantation of cryopreserved ovarian tissue. Lancet. 2004;363:837–40. https://doi.org/10.1016/S0140-6736(04)15728-0 .
doi: 10.1016/S0140-6736(04)15728-0
pubmed: 15031026
Dath C, Van Eyck AS, Dolmans MM, et al. Xenotransplantation of human ovarian tissue to nude mice: comparison between four grafting sites. Hum Reprod. 2010;25:1734–43. https://doi.org/10.1093/humrep/deq131 .
doi: 10.1093/humrep/deq131
pubmed: 20511300
Oktay K, Türkçüoğlu I, Rodriguez-Wallberg KA. Four spontaneous pregnancies and three live births following subcutaneous transplantation of frozen banked ovarian tissue: what is the explanation? Fertil Steril. 2011;95:804. https://doi.org/10.1016/j.fertnstert.2010.07.1072 .
doi: 10.1016/j.fertnstert.2010.07.1072
Sztein J, Sweet H, Farley J, Mobraaten L. Cryopreservation and orthotopic transplantation of mouse ovaries: new approach in gamete banking. Biol Reprod. 1998;58:1071–4. https://doi.org/10.1095/biolreprod58.4.1071 .
doi: 10.1095/biolreprod58.4.1071
pubmed: 9546742
Ishijima T, Kobayashi Y, Lee DS, et al. Cryopreservation of canine ovaries by vitrification. J Reprod Dev. 2006;52:293–9. https://doi.org/10.1262/jrd.17080 .
doi: 10.1262/jrd.17080
pubmed: 16394621
Deng XH, Xu AR, Chao L, et al. Effect of different sites for cryopreserved ovarian tissue implantation in rabbit. Hum Reprod. 2007;22:662–8. https://doi.org/10.1093/humrep/del430 .
doi: 10.1093/humrep/del430
pubmed: 17114193
Byrne M, Aly A. The surgical suture. Aesthet Surg J. 2019;39:67–72. https://doi.org/10.1093/asj/sjz036 .
doi: 10.1093/asj/sjz036
Grenz A, Schenk M, Zipfel A, Viebahn R. TNF-alpha and its receptors mediate graft rejection and loss after liver transplantation. Clin Chem Lab Med. 2000;38:1183–5. https://doi.org/10.1515/CCLM.2000.184 .
doi: 10.1515/CCLM.2000.184
pubmed: 11156356
Wolfram D, Starzl R, Hackl H, et al. Insights from computational modeling in inflammation and acute rejection in limb transplantation. PLoS One. 2014;9:e99926. https://doi.org/10.1371/journal.pone.0099926 .
doi: 10.1371/journal.pone.0099926
pubmed: 24926998
pmcid: 4057425
Chiang EF, Yan YL, Guiguen Y, Postlethwait J, Bc C. Two Cyp19 (P450 aromatase) genes on duplicated zebrafish chromosomes are expressed in ovary or brain. Mol Biol Evol. 2001;18:542–50. https://doi.org/10.1093/oxfordjournals.molbev.a003833 .
doi: 10.1093/oxfordjournals.molbev.a003833
pubmed: 11264405
Saint-Dizier M, Malandain E, Thoumire S, Remy B, Chastant-Maillard S. Expression of follicle stimulating hormone and luteinizing hormone receptors during follicular growth in the domestic cat ovary. Mol Reprod Dev. 2007;74:989–96. https://doi.org/10.1002/mrd.20676 .
doi: 10.1002/mrd.20676
pubmed: 17219419
Wang N, Si C, Xia L, et al. TRIB3 regulates FSHR expression in human granulosa cells under high levels of free fatty acids. Reprod Biol Endocrinol. 2021;19:139. https://doi.org/10.1186/s12958-021-00823-z .
doi: 10.1186/s12958-021-00823-z
pubmed: 34503515
pmcid: 8428109
Kaczmarek MM, Schams D, Ziecik AJ. Role of vascular endothelial growth factor in ovarian physiology - an overview. Reprod Biol. 2005;5:111–36.
pubmed: 16100562
Ravindranath N, Little-Ihrig L, Phillips HS, Ferrara N, Zeleznik AJ. Vascular endothelial growth factor messenger ribonucleic acid expression in the primate ovary. Endocrinology. 1992;131:254–60. https://doi.org/10.1210/endo.131.1.1612003 .
doi: 10.1210/endo.131.1.1612003
pubmed: 1612003
Imthurn B, Cox SL, Jenkin G, Trounson AO, Shaw JM. Gonadotrophin administration can benefit ovarian tissue grafted to the body wall: implications for human ovarian grafting. Mol Cell Endocrinol. 2000;163:141–6. https://doi.org/10.1016/s0303-7207(00)00218-5 .
doi: 10.1016/s0303-7207(00)00218-5
pubmed: 10963886
Ruiz de Adana JC, Hernández Matías A, Hernández Bartolomé M, et al. Risk of gastrojejunal anastomotic stricture with multifilament and monofilament sutures after hand-sewn laparoscopic gastric bypass: a prospective cohort study. Obes Surg. 2009;19:1274–7. https://doi.org/10.1007/s11695-009-9897-4 .
doi: 10.1007/s11695-009-9897-4
pubmed: 19557484
Al-Mubarak L, Al-Haddab M. Cutaneous wound closure materials: an overview and update. J Cutan Aesthet Surg. 2013;6:178–88. https://doi.org/10.4103/0974-2077.123395 .
doi: 10.4103/0974-2077.123395
pubmed: 24470712
pmcid: 3884880