Microtubules as a signal hub for axon growth in response to mechanical force.
axon growth
microtubule
traction force
Journal
Biological chemistry
ISSN: 1437-4315
Titre abrégé: Biol Chem
Pays: Germany
ID NLM: 9700112
Informations de publication
Date de publication:
29 Jan 2024
29 Jan 2024
Historique:
received:
04
04
2023
accepted:
12
08
2023
medline:
1
12
2023
pubmed:
7
9
2023
entrez:
7
9
2023
Statut:
epublish
Résumé
Microtubules are highly polar structures and are characterized by high anisotropy and stiffness. In neurons, they play a key role in the directional transport of vesicles and organelles. In the neuronal projections called axons, they form parallel bundles, mostly oriented with the plus-end towards the axonal termination. Their physico-chemical properties have recently attracted attention as a potential candidate in sensing, processing and transducing physical signals generated by mechanical forces. Here, we discuss the main evidence supporting the role of microtubules as a signal hub for axon growth in response to a traction force. Applying a tension to the axon appears to stabilize the microtubules, which, in turn, coordinate a modulation of axonal transport, local translation and their cross-talk. We speculate on the possible mechanisms modulating microtubule dynamics under tension, based on evidence collected in neuronal and non-neuronal cell types. However, the fundamental question of the causal relationship between these mechanisms is still elusive because the mechano-sensitive element in this chain has not yet been identified.
Identifiants
pubmed: 37674311
pii: hsz-2023-0173
doi: 10.1515/hsz-2023-0173
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
67-77Informations de copyright
© 2023 the author(s), published by De Gruyter, Berlin/Boston.
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