Solid-phase synthesis of oligodeoxynucleotides using nucleobase

Oligodeoxyribonucleotides / chemistry Solid-Phase Synthesis Techniques Oxazoles / chemistry Stereoisomerism

Journal

Organic & biomolecular chemistry
ISSN: 1477-0539
Titre abrégé: Org Biomol Chem
Pays: England
ID NLM: 101154995

Informations de publication

Date de publication:
27 09 2023
Historique:
medline: 28 9 2023
pubmed: 7 9 2023
entrez: 7 9 2023
Statut: epublish

Résumé

In this study, we developed a new approach for the solid-phase synthesis of oligodeoxynucleotides (ODNs) using nucleobase-unprotected oxazaphospholidine derivatives. We tackled the problem of the difficult purification of

Identifiants

DOI: 10.1039/d3ob01255g PMID: 37674464
pubmed: 37674464
doi: 10.1039/d3ob01255g
doi:

Substances chimiques

Oligodeoxyribonucleotides 0
Oxazoles 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

7580-7592

Auteurs

Kiyoshi Kakuta (K)

Department of Medicinal and Life Sciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan. twada@rs.tus.ac.jp.
ORCID: 0009-0007-2179-286X

Ryouta Kasahara (R)

Department of Medicinal and Life Sciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan. twada@rs.tus.ac.jp.

Kazuki Sato (K)

Department of Medicinal and Life Sciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan. twada@rs.tus.ac.jp.
ORCID: 0000-0001-9319-725X

Takeshi Wada (T)

Department of Medicinal and Life Sciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan. twada@rs.tus.ac.jp.
ORCID: 0000-0001-7403-4033

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Polynucléotides › Oligonucléotides › Oligodésoxyribonucléotides › Solid-phase synthesis of oligodeoxynucleotides...
questionsmedicales.fr › Technologie, industrie et agriculture › Technologie › Technologie pharmaceutique › Techniques de chimie synthétique › Techniques de synthèse en phase solide › Solid-phase synthesis of oligodeoxynucleotides...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Oxazoles › Solid-phase synthesis of oligodeoxynucleotides...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes de chimie organique › Isomérie › Stéréoisomérie › Solid-phase synthesis of oligodeoxynucleotides...