Advances in post-translational modifications of proteins and cancer immunotherapy.
phosphorylation
post-translational modification
succinylation
tumor immunotherapy
ubiquitylation
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
26
05
2023
accepted:
21
07
2023
medline:
8
9
2023
pubmed:
7
9
2023
entrez:
7
9
2023
Statut:
epublish
Résumé
Protein post-translational modification (PTM) is a regulatory mechanism for protein activity modulation, localization, expression, and interactions with other cellular molecules. It involves the addition or removal of specific chemical groups on the amino acid residues of proteins. Its common forms include phosphorylation, ubiquitylation, methylation, and acetylation. Emerging research has highlighted lactylation, succinylation, and glycosylation. PTMs are involved in vital biological processes. The occurrence and development of diseases depends on protein abundance and is regulated by various PTMs. In addition, advancements in tumor immunotherapy have revealed that protein PTM is also involved in the proliferation, activation, and metabolic reprogramming of immune cells in tumor microenvironment. These PTMs play an important role in tumor immunotherapy. In this review, we comprehensively summarize the role of several types of PTMs in tumor immunotherapy. This review could provide new insights and future research directions for tumor immunotherapy.
Identifiants
pubmed: 37675097
doi: 10.3389/fimmu.2023.1229397
pmc: PMC10477431
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1229397Informations de copyright
Copyright © 2023 Li, Zhang and Hei.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Nat Rev Drug Discov. 2011 Aug 01;10(8):591-600
pubmed: 21804596
Cancer Cell. 2019 Nov 11;36(5):483-497.e15
pubmed: 31679823
J Biol Chem. 2010 Nov 5;285(45):34864-74
pubmed: 20739279
Diabetes. 1991 May;40(5):540-7
pubmed: 1708734
Nat Immunol. 2002 Dec;3(12):1192-9
pubmed: 12415267
Biomolecules. 2021 Jan 05;11(1):
pubmed: 33466553
Mol Ther. 2021 Oct 6;29(10):2995-3010
pubmed: 33992804
Cell Metab. 2022 Sep 6;34(9):1312-1324.e6
pubmed: 36007522
Int J Mol Sci. 2022 Jun 29;23(13):
pubmed: 35806230
Int J Biol Sci. 2022 Oct 24;18(16):6210-6225
pubmed: 36439872
J Cancer Res Clin Oncol. 2022 Jan;148(1):137-153
pubmed: 34636991
Nucleic Acids Res. 2021 Dec 2;49(21):12211-12233
pubmed: 34865122
Nat Rev Clin Oncol. 2022 May;19(5):287-305
pubmed: 35132224
Theranostics. 2022 Jan 1;12(2):747-766
pubmed: 34976211
Cell Stem Cell. 2021 Apr 1;28(4):748-763.e7
pubmed: 33450185
Semin Immunol. 2018 Oct;39:102-110
pubmed: 29903548
Cancers (Basel). 2021 Aug 31;13(17):
pubmed: 34503213
J Clin Invest. 2021 Nov 1;131(21):
pubmed: 34499618
Curr Opin Biotechnol. 2020 Oct;65:60-64
pubmed: 32088576
Cell Mol Life Sci. 2021 May;78(9):4305-4333
pubmed: 33630111
J Clin Invest. 2017 Aug 1;127(8):2982-2997
pubmed: 28691927
Pharmacol Ther. 2018 Dec;192:88-99
pubmed: 29966598
Nat Commun. 2022 Jun 14;13(1):3419
pubmed: 35701426
Neurosci Biobehav Rev. 2021 Dec;131:59-76
pubmed: 34536462
Mol Aspects Med. 2021 Jun;79:100964
pubmed: 33775405
Cancer Gene Ther. 2023 May;30(5):641-646
pubmed: 35136215
J Clin Invest. 2019 Jul 15;129(8):3324-3338
pubmed: 31305264
Oncogene. 2022 Jul;41(27):3539-3553
pubmed: 35697803
Nat Cancer. 2021 Dec;2(12):1372-1386
pubmed: 35121903
BMC Cancer. 2023 Jan 16;23(1):52
pubmed: 36647029
Nat Metab. 2023 Jan;5(1):61-79
pubmed: 36593272
Nat Chem Biol. 2007 Jun;3(6):339-48
pubmed: 17496889
Cell. 2021 Oct 14;184(21):5309-5337
pubmed: 34624224
Clin Cancer Res. 2022 Jan 15;28(2):390-403
pubmed: 34921025
Cell Rep. 2017 Jun 13;19(11):2331-2344
pubmed: 28614718
Adv Exp Med Biol. 2019;1206:237-259
pubmed: 31776989
Breast Cancer (Auckl). 2020 Jan 22;14:1178223419882688
pubmed: 32030066
Mol Aspects Med. 2022 Aug;86:101097
pubmed: 35400524
Cell Rep. 2022 Jun 21;39(12):110986
pubmed: 35732125
J Hematol Oncol. 2020 Jul 2;13(1):86
pubmed: 32616000
Front Immunol. 2021 Nov 24;12:777665
pubmed: 34899735
Mol Cancer Res. 2021 Oct;19(10):1622-1634
pubmed: 34183449
Nat Med. 2018 May;24(5):541-550
pubmed: 29686425
Semin Cancer Biol. 2022 Oct;85:246-252
pubmed: 33831533
Int J Mol Sci. 2021 Aug 03;22(15):
pubmed: 34361089
Oncogene. 2021 Feb;40(5):1027-1042
pubmed: 33323973
Ann Nucl Med. 2021 Apr;35(4):514-522
pubmed: 33582981
Mol Cell. 2021 Jun 3;81(11):2303-2316.e8
pubmed: 33991485
Front Oncol. 2021 Mar 15;11:653037
pubmed: 33791228
Biomolecules. 2021 Jul 10;11(7):
pubmed: 34356634
Nat Rev Drug Discov. 2021 Jul;20(7):491-495
pubmed: 33953368
Cancer Cell. 2022 Oct 10;40(10):1207-1222.e10
pubmed: 36084651
Mol Metab. 2021 Nov;53:101272
pubmed: 34144215
Redox Biol. 2015 Aug;5:413
pubmed: 28162269
Nat Commun. 2016 Aug 30;7:12632
pubmed: 27572267
Nat Commun. 2020 Dec 8;11(1):6298
pubmed: 33293516
Nature. 2017 Dec 14;552(7684):273-277
pubmed: 29211711
Analyst. 2017 Nov 20;142(23):4373-4387
pubmed: 29094114
Nat Rev Mol Cell Biol. 2022 May;23(5):350-367
pubmed: 35079164
Clin Transl Med. 2021 Apr;11(4):e400
pubmed: 33931981
Oncogene. 2021 May;40(21):3655-3664
pubmed: 33947958
Int J Mol Sci. 2022 May 02;23(9):
pubmed: 35563444
Theranostics. 2020 Jul 9;10(19):8606-8618
pubmed: 32754266
EMBO Rep. 2023 May 4;24(5):e56052
pubmed: 36896611
Nature. 2019 Oct;574(7779):575-580
pubmed: 31645732
Cell Death Differ. 2022 Sep;29(9):1705-1718
pubmed: 35260822
Nat Cancer. 2020 Jan;1(1):122-135
pubmed: 35121836
Front Immunol. 2021 Dec 03;12:778098
pubmed: 34925352
J Immunother Cancer. 2021 Jan;9(1):
pubmed: 33462140
Acta Biomater. 2021 Sep 15;132:345-359
pubmed: 33857692
Cell Death Differ. 2021 Feb;28(2):427-438
pubmed: 33130827
Cancer Cell. 2018 Feb 12;33(2):187-201.e10
pubmed: 29438695
Front Immunol. 2023 Mar 03;14:1149989
pubmed: 36936929
Cancer Cell. 2015 Mar 9;27(3):370-81
pubmed: 25759022
Int J Biol Macromol. 2021 Aug 1;184:946-954
pubmed: 34182000
Trends Biochem Sci. 2021 Apr;46(4):258-269
pubmed: 33308996
JAMA. 2019 Jan 15;321(2):131-133
pubmed: 30566194
Cell Metab. 2023 Jun 6;35(6):961-978.e10
pubmed: 37178684