How can Cytokine-induced killer cells overcome CAR-T cell limits.
ATMP
CAR (chimeric antigen receptor) T cells
CIK (cytokine-induced killer) cells
GMP
GvHD
adoptive cell immunotherapy
hematological malignancies
solid tumors
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
26
05
2023
accepted:
02
08
2023
medline:
8
9
2023
pubmed:
7
9
2023
entrez:
7
9
2023
Statut:
epublish
Résumé
The successful treatment of patients affected by B-cell malignancies with Chimeric Antigen Receptor (CAR)-T cells represented a breakthrough in the field of adoptive cell therapy (ACT). However, CAR-T therapy is not an option for every patient, and several needs remain unmet. In particular, the production of CAR-T cells is expensive, labor-intensive and logistically challenging; additionally, the toxicities deriving from CAR-T cells infusion, such as cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS), have been documented extensively. Alternative cellular therapy products such as Cytokine-induced killer (CIK) cells have the potential to overcome some of these obstacles. CIK cells are a heterogeneous population of polyclonal CD3
Identifiants
pubmed: 37675107
doi: 10.3389/fimmu.2023.1229540
pmc: PMC10477668
doi:
Substances chimiques
cell-associated neurotoxicity
0
Receptors, Chimeric Antigen
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1229540Informations de copyright
Copyright © 2023 Cappuzzello, Vigolo, D’Accardio, Astori, Rosato and Sommaggio.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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