ADAMTS-7 Modulates Atherosclerotic Plaque Formation by Degradation of TIMP-1.

Animals Humans Mice ADAMTS7 Protein / genetics Atherosclerosis / genetics Collagen / metabolism Coronary Artery Disease / genetics Matrix Metalloproteinase 9 Plaque, Atherosclerotic / metabolism Tissue Inhibitor of Metalloproteinase-1 / genetics Mice, Knockout, ApoE
aorta atherosclerosis disintegrins mice solubility

Journal

Circulation research
ISSN: 1524-4571
Titre abrégé: Circ Res
Pays: United States
ID NLM: 0047103

Informations de publication

Date de publication:
29 09 2023
Historique:
medline: 2 10 2023
pubmed: 7 9 2023
entrez: 7 9 2023
Statut: ppublish

Résumé

The Targets of ADAMTS-7 were identified by high-resolution mass spectrometry of atherosclerotic plaques from Apoe In humans, ADAMTS-7, which is induced in unstable atherosclerotic plaques, decreases TIMP-1 stability reducing its inhibitory effect on MMP-9, which is known to promote collagen degradation and is likewise associated with coronary artery disease. Disrupting the interaction of ADAMTS-7 and TIMP-1 might be a strategy to increase collagen content and plaque stability for the reduction of atherosclerosis-related events.

Sections du résumé

BACKGROUND
The
METHODS
Targets of ADAMTS-7 were identified by high-resolution mass spectrometry of atherosclerotic plaques from Apoe
RESULTS
In humans,
CONCLUSIONS
ADAMTS-7, which is induced in unstable atherosclerotic plaques, decreases TIMP-1 stability reducing its inhibitory effect on MMP-9, which is known to promote collagen degradation and is likewise associated with coronary artery disease. Disrupting the interaction of ADAMTS-7 and TIMP-1 might be a strategy to increase collagen content and plaque stability for the reduction of atherosclerosis-related events.

Identifiants

DOI: 10.1161/CIRCRESAHA.123.322737 PMID: 37675562 PMC: PMC7615141
pubmed: 37675562
doi: 10.1161/CIRCRESAHA.123.322737
pmc: PMC7615141
mid: EMS187870
doi:

Substances chimiques

ADAMTS7 Protein EC 3.4.24.-
Collagen 9007-34-5
Matrix Metalloproteinase 9 EC 3.4.24.35
Tissue Inhibitor of Metalloproteinase-1 0
ADAMTS7 protein, human EC 3.4.24.-
Adamts7 protein, mouse EC 3.4.24.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

674-686

Subventions

Organisme : European Research Council
ID : 101077205
Pays : International
Organisme : British Heart Foundation
Pays : United Kingdom

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Auteurs

M Amin Sharifi (MA)

Department of Cardiology, German Heart Centre Munich, Technical University of Munich, Germany (M.A.S., T.A.D., A.M., M.v.S., J.H., P.M., J.W., B.S., H.B.S., H.S., T.K.).
German Centre for Cardiovascular Research (DZHK e.V.), partner site Munich Heart Alliance, Germany (M.A.S., T.A.D., M.v.S., J.H., P.M., J.W., L.M., J.B., H.B.S., H.S., T.K.).
ORCID: 0000-0003-3532-9271

Michael Wierer (M)

Department of Proteomics and Signal Transduction, Max-Planck Institute of Biochemistry, Martinsried, Germany (M.W., M.M.).
ORCID: 0000-0002-0356-5571

Tan An Dang (TA)

Department of Cardiology, German Heart Centre Munich, Technical University of Munich, Germany (M.A.S., T.A.D., A.M., M.v.S., J.H., P.M., J.W., B.S., H.B.S., H.S., T.K.).
German Centre for Cardiovascular Research (DZHK e.V.), partner site Munich Heart Alliance, Germany (M.A.S., T.A.D., M.v.S., J.H., P.M., J.W., L.M., J.B., H.B.S., H.S., T.K.).

Jelena Milic (J)

Division of Vascular Biology, Institute for Stroke and Dementia Research, Ludwig Maximilian University of Munich, Germany (J.M., J.B.).

Aldo Moggio (A)

Department of Cardiology, German Heart Centre Munich, Technical University of Munich, Germany (M.A.S., T.A.D., A.M., M.v.S., J.H., P.M., J.W., B.S., H.B.S., H.S., T.K.).
ORCID: 0000-0001-6513-5406

Nadja Sachs (N)

Vascular Biology and Experimental Vascular Medicine Unit, Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Germany (N.S., L.M.).
ORCID: 0000-0001-8031-017X

Moritz von Scheidt (M)

Department of Cardiology, German Heart Centre Munich, Technical University of Munich, Germany (M.A.S., T.A.D., A.M., M.v.S., J.H., P.M., J.W., B.S., H.B.S., H.S., T.K.).
German Centre for Cardiovascular Research (DZHK e.V.), partner site Munich Heart Alliance, Germany (M.A.S., T.A.D., M.v.S., J.H., P.M., J.W., L.M., J.B., H.B.S., H.S., T.K.).
ORCID: 0000-0001-7159-8271

Julia Hinterdobler (J)

Department of Cardiology, German Heart Centre Munich, Technical University of Munich, Germany (M.A.S., T.A.D., A.M., M.v.S., J.H., P.M., J.W., B.S., H.B.S., H.S., T.K.).
German Centre for Cardiovascular Research (DZHK e.V.), partner site Munich Heart Alliance, Germany (M.A.S., T.A.D., M.v.S., J.H., P.M., J.W., L.M., J.B., H.B.S., H.S., T.K.).

Philipp Müller (P)

Department of Cardiology, German Heart Centre Munich, Technical University of Munich, Germany (M.A.S., T.A.D., A.M., M.v.S., J.H., P.M., J.W., B.S., H.B.S., H.S., T.K.).
German Centre for Cardiovascular Research (DZHK e.V.), partner site Munich Heart Alliance, Germany (M.A.S., T.A.D., M.v.S., J.H., P.M., J.W., L.M., J.B., H.B.S., H.S., T.K.).
ORCID: 0000-0002-4850-0472

Julia Werner (J)

Department of Cardiology, German Heart Centre Munich, Technical University of Munich, Germany (M.A.S., T.A.D., A.M., M.v.S., J.H., P.M., J.W., B.S., H.B.S., H.S., T.K.).
German Centre for Cardiovascular Research (DZHK e.V.), partner site Munich Heart Alliance, Germany (M.A.S., T.A.D., M.v.S., J.H., P.M., J.W., L.M., J.B., H.B.S., H.S., T.K.).
ORCID: 0000-0002-4374-5374

Barbara Stiller (B)

Department of Cardiology, German Heart Centre Munich, Technical University of Munich, Germany (M.A.S., T.A.D., A.M., M.v.S., J.H., P.M., J.W., B.S., H.B.S., H.S., T.K.).

Zouhair Aherrahrou (Z)

Institute for Cardiogenetics and University Heart Centre Lübeck, University of Lübeck, Germany (Z.A., J.E.).
German Centre for Cardiovascular Research (DZHK e.V.), partner site Hamburg/Kiel/Lübeck, Germany (Z.A., J.E.).
ORCID: 0000-0002-1241-8733

Jeanette Erdmann (J)

Institute for Cardiogenetics and University Heart Centre Lübeck, University of Lübeck, Germany (Z.A., J.E.).
German Centre for Cardiovascular Research (DZHK e.V.), partner site Hamburg/Kiel/Lübeck, Germany (Z.A., J.E.).
ORCID: 0000-0002-4486-6231

Andrea Zaliani (A)

Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Hamburg, Germany (A.Z., M.G., J.R., S.G., P.G.).
Fraunhofer Cluster of Excellence for Immune-Mediated Diseases (CIMD), Hamburg, Germany (A.Z., M.G., J.R., S.G., P.G.).
ORCID: 0000-0002-1740-8390

Mira Graettinger (M)

Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Hamburg, Germany (A.Z., M.G., J.R., S.G., P.G.).
Fraunhofer Cluster of Excellence for Immune-Mediated Diseases (CIMD), Hamburg, Germany (A.Z., M.G., J.R., S.G., P.G.).
ORCID: 0000-0002-5909-4828

Jeanette Reinshagen (J)

Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Hamburg, Germany (A.Z., M.G., J.R., S.G., P.G.).
Fraunhofer Cluster of Excellence for Immune-Mediated Diseases (CIMD), Hamburg, Germany (A.Z., M.G., J.R., S.G., P.G.).
ORCID: 0000-0002-8080-9170

Sheraz Gul (S)

Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Hamburg, Germany (A.Z., M.G., J.R., S.G., P.G.).
Fraunhofer Cluster of Excellence for Immune-Mediated Diseases (CIMD), Hamburg, Germany (A.Z., M.G., J.R., S.G., P.G.).

Philip Gribbon (P)

Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Hamburg, Germany (A.Z., M.G., J.R., S.G., P.G.).
Fraunhofer Cluster of Excellence for Immune-Mediated Diseases (CIMD), Hamburg, Germany (A.Z., M.G., J.R., S.G., P.G.).
ORCID: 0000-0001-7655-2459

Lars Maegdefessel (L)

German Centre for Cardiovascular Research (DZHK e.V.), partner site Munich Heart Alliance, Germany (M.A.S., T.A.D., M.v.S., J.H., P.M., J.W., L.M., J.B., H.B.S., H.S., T.K.).
Vascular Biology and Experimental Vascular Medicine Unit, Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Germany (N.S., L.M.).
ORCID: 0000-0001-5228-2634

Jürgen Bernhagen (J)

German Centre for Cardiovascular Research (DZHK e.V.), partner site Munich Heart Alliance, Germany (M.A.S., T.A.D., M.v.S., J.H., P.M., J.W., L.M., J.B., H.B.S., H.S., T.K.).
Division of Vascular Biology, Institute for Stroke and Dementia Research, Ludwig Maximilian University of Munich, Germany (J.M., J.B.).

Hendrik B Sager (HB)

Department of Cardiology, German Heart Centre Munich, Technical University of Munich, Germany (M.A.S., T.A.D., A.M., M.v.S., J.H., P.M., J.W., B.S., H.B.S., H.S., T.K.).
German Centre for Cardiovascular Research (DZHK e.V.), partner site Munich Heart Alliance, Germany (M.A.S., T.A.D., M.v.S., J.H., P.M., J.W., L.M., J.B., H.B.S., H.S., T.K.).
ORCID: 0000-0002-0197-6553

Matthias Mann (M)

Department of Proteomics and Signal Transduction, Max-Planck Institute of Biochemistry, Martinsried, Germany (M.W., M.M.).
ORCID: 0000-0003-1292-4799

Heribert Schunkert (H)

Department of Cardiology, German Heart Centre Munich, Technical University of Munich, Germany (M.A.S., T.A.D., A.M., M.v.S., J.H., P.M., J.W., B.S., H.B.S., H.S., T.K.).
German Centre for Cardiovascular Research (DZHK e.V.), partner site Munich Heart Alliance, Germany (M.A.S., T.A.D., M.v.S., J.H., P.M., J.W., L.M., J.B., H.B.S., H.S., T.K.).
ORCID: 0000-0001-6428-3001

Thorsten Kessler (T)

Department of Cardiology, German Heart Centre Munich, Technical University of Munich, Germany (M.A.S., T.A.D., A.M., M.v.S., J.H., P.M., J.W., B.S., H.B.S., H.S., T.K.).
German Centre for Cardiovascular Research (DZHK e.V.), partner site Munich Heart Alliance, Germany (M.A.S., T.A.D., M.v.S., J.H., P.M., J.W., L.M., J.B., H.B.S., H.S., T.K.).
ORCID: 0000-0003-3326-1621

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › ADAMTS-7 Modulates Atherosclerotic Plaque...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › ADAMTS-7 Modulates Atherosclerotic Plaque...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › ADAMTS-7 Modulates Atherosclerotic Plaque...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Scléroprotéines › Protéines de la matrice extracellulaire › Protéines ADAMTS › Protéine ADAMTS7 › ADAMTS-7 Modulates Atherosclerotic Plaque...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Artériopathies oblitérantes › Artériosclérose › Athérosclérose › ADAMTS-7 Modulates Atherosclerotic Plaque...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Scléroprotéines › Protéines de la matrice extracellulaire › Collagène › ADAMTS-7 Modulates Atherosclerotic Plaque...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Ischémie myocardique › Maladie coronarienne › Maladie des artères coronaires › ADAMTS-7 Modulates Atherosclerotic Plaque...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Secreted matrix metalloproteinases › Matrix metalloproteinase 9 › ADAMTS-7 Modulates Atherosclerotic Plaque...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Plaque d'athérosclérose › ADAMTS-7 Modulates Atherosclerotic Plaque...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines sécrétoires inhibitrices de protéinases › Inhibiteur tissulaire des métalloprotéinases › Inhibiteur tissulaire de métalloprotéinase-1 › ADAMTS-7 Modulates Atherosclerotic Plaque...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Souris invalidées pour les gènes ApoE › ADAMTS-7 Modulates Atherosclerotic Plaque...