PARP1 inhibition protects mice against Japanese encephalitis virus infection.

Child Humans Encephalitis, Japanese / drug therapy Encephalitis Virus, Japanese Proto-Oncogene Proteins c-akt Brain / pathology Poly (ADP-Ribose) Polymerase-1
AKT CP: Microbiology FoxO JEV PARP1 PARylation PTEN antiviral autophagy flavivirus olaparib

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
26 09 2023
Historique:
received: 09 06 2021
revised: 20 05 2023
accepted: 22 08 2023
medline: 5 10 2023
pubmed: 7 9 2023
entrez: 7 9 2023
Statut: ppublish

Résumé

Japanese encephalitis (JE) is a vector-borne viral disease that causes acute encephalitis in children. Although vaccines have been developed against the JE virus (JEV), no effective antiviral therapy exists. Our study shows that inhibition of poly(ADP-ribose) polymerase 1 (PARP1), an NAD

Identifiants

DOI: 10.1016/j.celrep.2023.113103 PMID: 37676769
pubmed: 37676769
pii: S2211-1247(23)01114-2
doi: 10.1016/j.celrep.2023.113103
pii:
doi:

Substances chimiques

Proto-Oncogene Proteins c-akt EC 2.7.11.1
PARP1 protein, human EC 2.4.2.30
Poly (ADP-Ribose) Polymerase-1 EC 2.4.2.30

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

113103

Informations de copyright

Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Perumal Arumugam Desingu (PA)

Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru 560012, India. Electronic address: padesingu@gmail.com.

Sneha Mishra (S)

Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru 560012, India.

Lavanya Dindi (L)

Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru 560012, India.

Shalini Srinivasan (S)

Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru 560012, India.

Raju S Rajmani (RS)

Centre for Infectious Disease Research, Indian Institute of Science, Bengaluru 560012, India.

Venkatraman Ravi (V)

Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru 560012, India.

Ankit Kumar Tamta (AK)

Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru 560012, India.

Sukanya Raghu (S)

Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru 560012, India.

Krishnega Murugasamy (K)

Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru 560012, India.

Anwit Shriniwas Pandit (AS)

Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru 560012, India.

Nagalingam R Sundaresan (NR)

Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru 560012, India. Electronic address: rsundaresan@iisc.ac.in.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › PARP1 inhibition protects mice against...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › PARP1 inhibition protects mice against...
questionsmedicales.fr › Maladies du système nerveux › Encéphalite › Encéphalite infectieuse › Encéphalite virale › Encéphalite à arbovirus › Encéphalite japonaise › PARP1 inhibition protects mice against...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Flaviviridae › Flavivirus › Virus de l'encéphalite japonaise (sous-groupe) › Virus de l'encéphalite japonaise (espèce) › PARP1 inhibition protects mice against...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes c-akt › PARP1 inhibition protects mice against...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › PARP1 inhibition protects mice against...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Glycosyltransferase › Pentosyltransferases › ADP ribose transferases › Poly(ADP-ribose) polymerases › Poly (ADP-Ribose) polymerase-1 › PARP1 inhibition protects mice against...