Aflibercept Loaded Eye-Drop Hydrogel Mediated with Cell-Penetrating Peptide for Corneal Neovascularization Treatment.
cell penetrating peptide
corneal neovascularization
peptide hydrogel
self-assembly
Journal
Small (Weinheim an der Bergstrasse, Germany)
ISSN: 1613-6829
Titre abrégé: Small
Pays: Germany
ID NLM: 101235338
Informations de publication
Date de publication:
07 Sep 2023
07 Sep 2023
Historique:
revised:
30
08
2023
received:
02
04
2023
medline:
8
9
2023
pubmed:
8
9
2023
entrez:
7
9
2023
Statut:
aheadofprint
Résumé
Corneal neovascularization (CoNV) is a major cause of visual impairment worldwide. Currently, available treatment options have limited efficacy and are associated with adverse effects due to biological barriers and clearance mechanisms. To address this challenge, a novel topical delivery system is developed-Gel 2_1&Eylea-an aflibercept-loaded eye-drop hydrogel mediated with cell-penetrating peptide 1. Gel 2_1&Eylea demonstrates superior membrane permeability, increased stability, and prolonged drug retention time on the ocular surface, and thus may improve drug efficacy. In a rabbit CoNV model, Gel 2_1&Eylea significantly reduces the density of neovascularization with no adverse effects on normal corneoscleral limbal vessels, demonstrating high efficacy and biocompatibility. This work identifies a promising treatment for CoNV which has the potential to benefit other ocular neovascular diseases.
Identifiants
pubmed: 37679056
doi: 10.1002/smll.202302765
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2302765Subventions
Organisme : National Natural Science Foundation of China
ID : 82171087
Organisme : National Natural Science Foundation of China
ID : 21975068
Organisme : Natural Science Foundation of Hunan
ID : 2020RC3017
Organisme : Natural Science Foundation of Hunan
ID : 2022JJ10008
Organisme : Science and Technology and Development Foundation of Shenzhen
ID : JCYJ20210324122403010
Organisme : Science and Technology and Development Foundation of Shenzhen
ID : JCYJ20210324133611030
Organisme : Hunan Provincial Health Commission grant
ID : 202207022581
Organisme : Natural Science Foundation of Changsha
ID : kq2202152
Organisme : Natural Science Foundation of Hunan Province
ID : 2021R1A4A3030268
Informations de copyright
© 2023 Wiley-VCH GmbH.
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