Strategy to combat biofilms: a focus on biofilm dispersal enzymes.


Journal

NPJ biofilms and microbiomes
ISSN: 2055-5008
Titre abrégé: NPJ Biofilms Microbiomes
Pays: United States
ID NLM: 101666944

Informations de publication

Date de publication:
07 09 2023
Historique:
received: 20 04 2023
accepted: 15 08 2023
medline: 11 9 2023
pubmed: 8 9 2023
entrez: 7 9 2023
Statut: epublish

Résumé

Bacterial biofilms, which consist of three-dimensional extracellular polymeric substance (EPS), not only function as signaling networks, provide nutritional support, and facilitate surface adhesion, but also serve as a protective shield for the residing bacterial inhabitants against external stress, such as antibiotics, antimicrobials, and host immune responses. Biofilm-associated infections account for 65-80% of all human microbial infections that lead to serious mortality and morbidity. Tremendous effort has been spent to address the problem by developing biofilm-dispersing agents to discharge colonized microbial cells to a more vulnerable planktonic state. Here, we discuss the recent progress of enzymatic eradicating strategies against medical biofilms, with a focus on dispersal mechanisms. Particularly, we review three enzyme classes that have been extensively investigated, namely glycoside hydrolases, proteases, and deoxyribonucleases.

Identifiants

pubmed: 37679355
doi: 10.1038/s41522-023-00427-y
pii: 10.1038/s41522-023-00427-y
pmc: PMC10485009
doi:

Substances chimiques

Anti-Bacterial Agents 0

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

63

Informations de copyright

© 2023. Springer Nature Limited.

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Auteurs

Shaochi Wang (S)

Otorhinolaryngology Hospital, The First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, China.
Translational Medicine Center, The First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, China.

Yanteng Zhao (Y)

Translational Medicine Center, The First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, China.

Alexandra P Breslawec (AP)

Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, 20740, USA.

Tingting Liang (T)

Key Laboratory of Natural Medicine and Immune-Engineering of Henan Province, Henan University Jinming Campus, 475004, Kaifeng, Henan, China.

Zhifen Deng (Z)

Translational Medicine Center, The First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, China.

Laura L Kuperman (LL)

Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, 20740, USA. lkuperma@terpmail.umd.edu.
Mirimus Inc., 760 Parkside Avenue, Brooklyn, NY, 11226, USA. lkuperma@terpmail.umd.edu.

Qiuning Yu (Q)

Otorhinolaryngology Hospital, The First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, China. yuqiuning@126.com.

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