Lysophosphatidic Acid Signalling Regulates Human Sperm Viability via the Phosphoinositide 3-Kinase/AKT Pathway.

AKT substrates LPA receptors PI3K lipid signalling lysophosphatidic acid protein kinase C spermatozoa

Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
02 09 2023
Historique:
received: 21 07 2023
revised: 24 08 2023
accepted: 29 08 2023
medline: 11 9 2023
pubmed: 8 9 2023
entrez: 8 9 2023
Statut: epublish

Résumé

Lysophosphatidic acid (LPA) signalling is essential for maintaining germ cell viability during mouse spermatogenesis; however, its role in human spermatozoa is unknown. We previously demonstrated that peroxiredoxin 6 (PRDX6) calcium-independent phospholipase A

Identifiants

pubmed: 37681929
pii: cells12172196
doi: 10.3390/cells12172196
pmc: PMC10486690
pii:
doi:

Substances chimiques

lysophosphatidic acid PG6M3969SG
Lysophospholipids 0
Peroxiredoxin VI EC 1.11.1.15
Phosphatidylinositol 3-Kinases EC 2.7.1.-
Proto-Oncogene Proteins c-akt EC 2.7.11.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : CIHR
ID : PJT165962
Pays : Canada

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Auteurs

Hao-Yu Liao (HY)

Department of Medicine, Experimental Medicine Division, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC H3A 0G4, Canada.
Department of Surgery, Urology Division, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC H3A 0G4, Canada.
The Research Institute, McGill University Health Centre, Montreal, QC H4A 3J1, Canada.

Cristian O'Flaherty (C)

Department of Medicine, Experimental Medicine Division, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC H3A 0G4, Canada.
Department of Surgery, Urology Division, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC H3A 0G4, Canada.
The Research Institute, McGill University Health Centre, Montreal, QC H4A 3J1, Canada.
Department of Anatomy and Cell Biology, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC H3A 0G4, Canada.
Department of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC H3A 0G4, Canada.

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Classifications MeSH