Efficient production of α-ketoglutaric acid using an economical double-strain cultivation and catalysis system.

Alpha-ketoglutaric acid Biocatalysis Double-strain cultivation Low-dosage-IPTG

Journal

Applied microbiology and biotechnology
ISSN: 1432-0614
Titre abrégé: Appl Microbiol Biotechnol
Pays: Germany
ID NLM: 8406612

Informations de publication

Date de publication:
Nov 2023
Historique:
received: 06 04 2023
accepted: 30 08 2023
revised: 03 08 2023
pubmed: 8 9 2023
medline: 8 9 2023
entrez: 8 9 2023
Statut: ppublish

Résumé

The whole-cell catalysis strategy of alpha-ketoglutaric acid (α-KG) production from L-glutamic acid (L-Glu) using recombinant Escherichia coli, in which L-glutamate oxidase (LGox) was over-expressed, has replaced the traditional chemical synthesis strategy. However, large amounts of toxic by-product, H

Identifiants

DOI: 10.1007/s00253-023-12757-0 PMID: 37682299
pubmed: 37682299
doi: 10.1007/s00253-023-12757-0
pii: 10.1007/s00253-023-12757-0
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

6497-6506

Subventions

Organisme : Science Foundation for The Excellent Youth Scholars of Anhui Provincial Education Department
ID : 2022AH030097
Organisme : Science and Technology Plan Project of Wuhu
ID : 2022jc19

Informations de copyright

© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

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Auteurs

Kun Liu (K)

Anhui Engineering Laboratory for Industrial Microbiology Molecular Breeding, College of Biology and Food Engineering, Anhui Polytechnic University, Wuhu, 241000, China.

Yan Liu (Y)

Anhui Engineering Laboratory for Industrial Microbiology Molecular Breeding, College of Biology and Food Engineering, Anhui Polytechnic University, Wuhu, 241000, China.

Xiangfei Li (X)

Anhui Engineering Laboratory for Industrial Microbiology Molecular Breeding, College of Biology and Food Engineering, Anhui Polytechnic University, Wuhu, 241000, China.

Xiushan Zhang (X)

Anhui Engineering Laboratory for Industrial Microbiology Molecular Breeding, College of Biology and Food Engineering, Anhui Polytechnic University, Wuhu, 241000, China.

Zhenglian Xue (Z)

Anhui Engineering Laboratory for Industrial Microbiology Molecular Breeding, College of Biology and Food Engineering, Anhui Polytechnic University, Wuhu, 241000, China. xuezl@ahpu.edu.cn.

Ming Zhao (M)

Anhui Engineering Laboratory for Industrial Microbiology Molecular Breeding, College of Biology and Food Engineering, Anhui Polytechnic University, Wuhu, 241000, China. zhaom@mail.ahpu.edu.cn.
ORCID: 0000-0003-2492-4606

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