Implications of Complete Posterior Vitreous Detachment in Eyes with Central Retinal Vein Occlusion.

To evaluate the status of the posterior vitreous hyaloid on presenting optical coherence tomography (OCT) images of the macula and its relationship to clinical characteristics, treatment patterns, and outcomes in eyes with central retinal vein occlusion (CRVO). This is a retrospective longitudinal cohort study of consecutive patients with acute, treatment-naïve CRVO diagnosed between 2009-2021 who had at least 12 months of follow-up. Clinical characteristics, treatment patterns, and outcomes were analyzed between eyes stratified based on presence or absence of a complete posterior vitreous detachment (PVD) on OCT at presentation. Of 102 acute, treatment-naïve CRVOs identified, 52 (51%) had complete PVD at presentation, and 50 (49%) did not. Central subfield thickness (CST) was significantly lower in those with complete PVD (12 months: 284.9 ± 122.9 μm vs 426.8 ± 286.4 μm, p<0.001; last follow-up: (278 ± 127.9 vs 372.8 ± 191.0 μm, p=0.022). One-year intravitreal injection burden was significantly less for those with a complete PVD than those without (5.1 ± 3.6 injections vs 6.7 ± 3.3 injections, p=0.013). CRVO with complete PVD on presentation had significantly lower CST and 1-year injection burden. Assessment of the vitreomacular interface in CRVO may serve as a prognostic imaging biomarker.

Déclaration de conflit d'intérêts

Conflict of Interest: No authors have financial or proprietary interests.