Antihypertensive peptide resources map of ribulose-1,5-bisphosphate carboxylase/oxygenases (RuBisCO) in angiosperms: Revealed by an integrated in silico and in vitro approach.

Angiotensin-I-converting enzyme Antihypertensive peptide Inhibitory mechanism Molecular docking RuBisCO

Journal

Food chemistry
ISSN: 1873-7072
Titre abrégé: Food Chem
Pays: England
ID NLM: 7702639

Informations de publication

Date de publication:
01 Feb 2024
Historique:
received: 10 11 2022
revised: 29 04 2023
accepted: 28 08 2023
pubmed: 9 9 2023
medline: 9 9 2023
entrez: 8 9 2023
Statut: ppublish

Résumé

As the most abundant protein on earth, ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) has been considered a promising resource of functional foods. This study aimed to explore the full potential of plant RuBisCO proteins as precursors of antihypertensive peptides on a large scale. In total, 12,766 RuBisCO large subunit and 1,020 RuBisCO small subunit sequences of angiosperms were collected for simulated proteolysis and evaluation of antihypertensive potential, revealing a vast reservoir of antihypertensive peptides. Moreover, RuBisCO-derived novel antihypertensive peptides TTVW, TMW, and VPCL were identified with in vitro IC

Identifiants

DOI: 10.1016/j.foodchem.2023.137332 PMID: 37683466
pubmed: 37683466
pii: S0308-8146(23)01950-7
doi: 10.1016/j.foodchem.2023.137332
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

137332

Informations de copyright

Copyright © 2023 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Haoyue Shu (H)

School of Food and Drug, Shenzhen Polytechnic University, Shenzhen 518055, China; Postdoctoral Innovation Practice Base, Shenzhen Polytechnic University, Shenzhen 518055, China; State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China. Electronic address: shuhaoyue@szpt.edu.cn.

Qingcui Zhao (Q)

School of Food and Drug, Shenzhen Polytechnic University, Shenzhen 518055, China; Postdoctoral Innovation Practice Base, Shenzhen Polytechnic University, Shenzhen 518055, China; State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China. Electronic address: zhaoqingcui@szpt.edu.cn.

Yu Huang (Y)

Shenzhen Key Lab of Marine Genomics, Guangdong Provincial Key Lab of Molecular Breeding in Marine Economic Animals, BGI Academy of Marine Sciences, BGI Marine, Shenzhen 518081, China. Electronic address: huangyu@genomics.cn.

Qiong Shi (Q)

Shenzhen Key Lab of Marine Genomics, Guangdong Provincial Key Lab of Molecular Breeding in Marine Economic Animals, BGI Academy of Marine Sciences, BGI Marine, Shenzhen 518081, China. Electronic address: shiqiong@genomics.cn.

Jian Yang (J)

School of Food and Drug, Shenzhen Polytechnic University, Shenzhen 518055, China; Postdoctoral Innovation Practice Base, Shenzhen Polytechnic University, Shenzhen 518055, China. Electronic address: jiany@szpt.edu.cn.

Classifications MeSH