Factor XII promotes the thromboinflammatory response in a rat model of venoarterial extracorporeal membrane oxygenation.
complement
extracorporeal circulation
factor XII
high molecular weight cleavage
inflammation
neutrophil
Journal
The Journal of thoracic and cardiovascular surgery
ISSN: 1097-685X
Titre abrégé: J Thorac Cardiovasc Surg
Pays: United States
ID NLM: 0376343
Informations de publication
Date de publication:
07 Sep 2023
07 Sep 2023
Historique:
received:
05
05
2023
revised:
26
07
2023
accepted:
15
08
2023
pubmed:
9
9
2023
medline:
9
9
2023
entrez:
8
9
2023
Statut:
aheadofprint
Résumé
Factor XII (FXII) is a multifunctional protease capable of activating thrombotic and inflammatory pathways. FXII has been linked to thrombosis in extracorporeal membrane oxygenation (ECMO), but the role of FXII in ECMO-induced inflammatory complications has not been studied. We used novel gene-targeted FXII- deficient rats to evaluate the role of FXII in ECMO-induced thromboinflammation. FXII-deficient (FXII FXII FXII initiates hemostatic system activation and key inflammatory sequelae in ECMO, suggesting that therapies targeting FXII could limit both thromboembolism and inopportune inflammatory complications in this setting.
Sections du résumé
BACKGROUND
BACKGROUND
Factor XII (FXII) is a multifunctional protease capable of activating thrombotic and inflammatory pathways. FXII has been linked to thrombosis in extracorporeal membrane oxygenation (ECMO), but the role of FXII in ECMO-induced inflammatory complications has not been studied. We used novel gene-targeted FXII- deficient rats to evaluate the role of FXII in ECMO-induced thromboinflammation.
METHODS
METHODS
FXII-deficient (FXII
RESULTS
RESULTS
FXII
CONCLUSIONS
CONCLUSIONS
FXII initiates hemostatic system activation and key inflammatory sequelae in ECMO, suggesting that therapies targeting FXII could limit both thromboembolism and inopportune inflammatory complications in this setting.
Identifiants
pubmed: 37683721
pii: S0022-5223(23)00756-0
doi: 10.1016/j.jtcvs.2023.08.045
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL160582
Pays : United States
Informations de copyright
Copyright © 2023 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.