Fasting mimicking diet in mice delays cancer growth and reduces immunotherapy-associated cardiovascular and systemic side effects.


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
08 09 2023
Historique:
received: 08 11 2022
accepted: 22 08 2023
medline: 11 9 2023
pubmed: 9 9 2023
entrez: 8 9 2023
Statut: epublish

Résumé

Immune checkpoint inhibitors cause side effects ranging from autoimmune endocrine disorders to severe cardiotoxicity. Periodic Fasting mimicking diet (FMD) cycles are emerging as promising enhancers of a wide range of cancer therapies including immunotherapy. Here, either FMD cycles alone or in combination with anti-OX40/anti-PD-L1 are much more effective than immune checkpoint inhibitors alone in delaying melanoma growth in mice. FMD cycles in combination with anti-OX40/anti-PD-L1 also show a trend for increased effects against a lung cancer model. As importantly, the cardiac fibrosis, necrosis and hypertrophy caused by immune checkpoint inhibitors are prevented/reversed by FMD treatment in both cancer models whereas immune infiltration of CD3

Identifiants

pubmed: 37684243
doi: 10.1038/s41467-023-41066-3
pii: 10.1038/s41467-023-41066-3
pmc: PMC10491752
doi:

Substances chimiques

Immune Checkpoint Inhibitors 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

5529

Informations de copyright

© 2023. Springer Nature Limited.

Références

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Auteurs

S Cortellino (S)

IFOM, The AIRC Institute of Molecular Oncology, 20139, Milan, Italy.
Laboratory of Pre-Clinical and Translational Research, IRCCS-CROB, Referral Cancer Center of Basilicata, 85028, Rionero in Vulture, Italy.

V Quagliariello (V)

Division of Cardiology, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, Naples, Italy.

G Delfanti (G)

Experimental Immunology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.

O Blaževitš (O)

IFOM, The AIRC Institute of Molecular Oncology, 20139, Milan, Italy.

C Chiodoni (C)

Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.

N Maurea (N)

Division of Cardiology, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, Naples, Italy.

A Di Mauro (A)

Pathology and Cytopathology Unit, Department of Support to Cancer Pathways Diagnostics Area, Istituto Nazionale Tumori-IRCCS "Fondazione G. Pascale", 80131, Naples, Italy.

F Tatangelo (F)

Pathology and Cytopathology Unit, Department of Support to Cancer Pathways Diagnostics Area, Istituto Nazionale Tumori-IRCCS "Fondazione G. Pascale", 80131, Naples, Italy.

F Pisati (F)

Histopathology Unit, Cogentech Società Benefit srl, 20139, Milan, Italy.

A Shmahala (A)

IFOM, The AIRC Institute of Molecular Oncology, 20139, Milan, Italy.

S Lazzeri (S)

IFOM, The AIRC Institute of Molecular Oncology, 20139, Milan, Italy.

V Spagnolo (V)

IFOM, The AIRC Institute of Molecular Oncology, 20139, Milan, Italy.

E Visco (E)

IFOM, The AIRC Institute of Molecular Oncology, 20139, Milan, Italy.

C Tripodo (C)

IFOM, The AIRC Institute of Molecular Oncology, 20139, Milan, Italy.
University of Palermo School of Medicine, Palermo, Italy.

G Casorati (G)

Experimental Immunology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.

P Dellabona (P)

Experimental Immunology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.

V D Longo (VD)

IFOM, The AIRC Institute of Molecular Oncology, 20139, Milan, Italy. vlongo@usc.edu.
Longevity Institute and Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA. vlongo@usc.edu.

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