Cyclin D1-Cdk4 regulates neuronal activity through phosphorylation of GABAA receptors.

Animals Mice Rats Cyclin D1 / genetics gamma-Aminobutyric Acid Mice, Knockout Neurons Phosphorylation Receptors, GABA-A / genetics Cyclin-Dependent Kinase 4 / genetics
Cdk4 Cyclin D1 GABA signalling Gamma-Aminobutyric acid type A receptor subunit alpha 4

Journal

Cellular and molecular life sciences : CMLS
ISSN: 1420-9071
Titre abrégé: Cell Mol Life Sci
Pays: Switzerland
ID NLM: 9705402

Informations de publication

Date de publication:
08 Sep 2023
Historique:
received: 14 06 2023
accepted: 12 08 2023
revised: 10 08 2023
medline: 11 9 2023
pubmed: 9 9 2023
entrez: 8 9 2023
Statut: epublish

Résumé

Nuclear Cyclin D1 (Ccnd1) is a main regulator of cell cycle progression and cell proliferation. Interestingly, Ccnd1 moves to the cytoplasm at the onset of differentiation in neuronal precursors. However, cytoplasmic functions and targets of Ccnd1 in post-mitotic neurons are unknown. Here we identify the α4 subunit of gamma-aminobutyric acid (GABA) type A receptors (GABA

Identifiants

DOI: 10.1007/s00018-023-04920-7 PMID: 37684532 PMC: PMC10491536
pubmed: 37684532
doi: 10.1007/s00018-023-04920-7
pii: 10.1007/s00018-023-04920-7
pmc: PMC10491536
doi:

Substances chimiques

Cyclin D1 136601-57-5
gamma-Aminobutyric Acid 56-12-2
Receptors, GABA-A 0
Cyclin-Dependent Kinase 4 EC 2.7.11.22

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

280

Subventions

Organisme : Spanish Ministry of Innovation and Science MICINN
ID : PID2019-104859GB-I00

Informations de copyright

© 2023. The Author(s).

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Auteurs

Neus Pedraza (N)

Cell Cycle, Department of Basic Medical Sciences, Institut de Recerca Biomèdica de Lleida (IRBLLEIDA), University of Lleida, Lleida, Spain. neus.pedraza@udl.cat.

Ma Ventura Monserrat (MV)

Cell Cycle, Department of Basic Medical Sciences, Institut de Recerca Biomèdica de Lleida (IRBLLEIDA), University of Lleida, Lleida, Spain.

Francisco Ferrezuelo (F)

Cell Cycle, Department of Basic Medical Sciences, Institut de Recerca Biomèdica de Lleida (IRBLLEIDA), University of Lleida, Lleida, Spain.

Jordi Torres-Rosell (J)

Cell Cycle, Department of Basic Medical Sciences, Institut de Recerca Biomèdica de Lleida (IRBLLEIDA), University of Lleida, Lleida, Spain.

Neus Colomina (N)

Cell Cycle, Department of Basic Medical Sciences, Institut de Recerca Biomèdica de Lleida (IRBLLEIDA), University of Lleida, Lleida, Spain.

Federico Miguez-Cabello (F)

Laboratori de Neurofisiologia, Departament de Biomedicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain.
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.

Javier Picañol Párraga (JP)

Laboratori de Neurofisiologia, Departament de Biomedicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain.
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.

David Soto (D)

Laboratori de Neurofisiologia, Departament de Biomedicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain.
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.

Esperanza López-Merino (E)

Department of Molecular Neurobiology, Centro de Biología Molecular 'Severo Ochoa', Consejo Superior de Investigaciones Científicas (CSIC)/Universidad Autónoma de Madrid (UAM), Madrid, Spain.

Celia García-Vilela (C)

Department of Molecular Neurobiology, Centro de Biología Molecular 'Severo Ochoa', Consejo Superior de Investigaciones Científicas (CSIC)/Universidad Autónoma de Madrid (UAM), Madrid, Spain.

José A Esteban (JA)

Department of Molecular Neurobiology, Centro de Biología Molecular 'Severo Ochoa', Consejo Superior de Investigaciones Científicas (CSIC)/Universidad Autónoma de Madrid (UAM), Madrid, Spain.

Joaquim Egea (J)

Molecular and Developmental Neurobiology, Dept. Ciències Mèdiques Bàsiques, Facultat de Medicina, Universitat de Lleida/IRBLLEIDA, Rovira Roure 80, 25198, Lleida, Spain.

Eloi Garí (E)

Cell Cycle, Department of Basic Medical Sciences, Institut de Recerca Biomèdica de Lleida (IRBLLEIDA), University of Lleida, Lleida, Spain. eloi.gari@udl.cat.
ORCID: 0000-0002-3505-4901

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Cyclin D1-Cdk4 regulates neuronal activity...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Cyclin D1-Cdk4 regulates neuronal activity...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Cyclin D1-Cdk4 regulates neuronal activity...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Cycline D1 › Cyclin D1-Cdk4 regulates neuronal activity...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Amino-butyrates › Acide gamma-amino-butyrique › Cyclin D1-Cdk4 regulates neuronal activity...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Cyclin D1-Cdk4 regulates neuronal activity...
questionsmedicales.fr › Cellules › Neurones › Cyclin D1-Cdk4 regulates neuronal activity...
questionsmedicales.fr › Métabolisme › Phosphorylation › Cyclin D1-Cdk4 regulates neuronal activity...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs GABA › Récepteurs GABA-A › Cyclin D1-Cdk4 regulates neuronal activity...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Proline-directed protein kinases › Kinases cyclines-dépendantes › Kinase-4 cycline-dépendante › Cyclin D1-Cdk4 regulates neuronal activity...